{"id":"https://openalex.org/W1994417022","doi":"https://doi.org/10.1109/cvpr.2010.5539846","title":"Increasing depth resolution of electron microscopy of neural circuits using sparse tomographic reconstruction","display_name":"Increasing depth resolution of electron microscopy of neural circuits using sparse tomographic reconstruction","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W1994417022","doi":"https://doi.org/10.1109/cvpr.2010.5539846","mag":"1994417022"},"language":"en","primary_location":{"id":"doi:10.1109/cvpr.2010.5539846","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cvpr.2010.5539846","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073971393","display_name":"Ashok Veeraraghavan","orcid":"https://orcid.org/0000-0001-5043-7460"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ashok Veeraraghavan","raw_affiliation_strings":["MERL, Cambridge, MA, USA","MERL, Cambridge MA"],"affiliations":[{"raw_affiliation_string":"MERL, Cambridge, MA, USA","institution_ids":[]},{"raw_affiliation_string":"MERL, Cambridge MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019046992","display_name":"Alex Genkin","orcid":null},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex. V. Genkin","raw_affiliation_strings":["HHMI, Ashburn, VA, USA","HHMI, Ashburn, VA"],"affiliations":[{"raw_affiliation_string":"HHMI, Ashburn, VA, USA","institution_ids":["https://openalex.org/I195573530"]},{"raw_affiliation_string":"HHMI, Ashburn, VA","institution_ids":["https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069416097","display_name":"Shiv Vitaladevuni","orcid":"https://orcid.org/0000-0003-2709-5145"},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiv Vitaladevuni","raw_affiliation_strings":["HHMI, Ashburn, VA, USA","HHMI, Ashburn, VA"],"affiliations":[{"raw_affiliation_string":"HHMI, Ashburn, VA, USA","institution_ids":["https://openalex.org/I195573530"]},{"raw_affiliation_string":"HHMI, Ashburn, VA","institution_ids":["https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039448967","display_name":"Lou Scheffer","orcid":null},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lou Scheffer","raw_affiliation_strings":["HHMI, Ashburn, VA, USA","HHMI, Ashburn, VA"],"affiliations":[{"raw_affiliation_string":"HHMI, Ashburn, VA, USA","institution_ids":["https://openalex.org/I195573530"]},{"raw_affiliation_string":"HHMI, Ashburn, VA","institution_ids":["https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036610170","display_name":"Shan Xu","orcid":"https://orcid.org/0000-0002-8487-2046"},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Xu","raw_affiliation_strings":["HHMI, Ashburn, VA, USA","HHMI, Ashburn, VA"],"affiliations":[{"raw_affiliation_string":"HHMI, Ashburn, VA, USA","institution_ids":["https://openalex.org/I195573530"]},{"raw_affiliation_string":"HHMI, Ashburn, VA","institution_ids":["https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068937717","display_name":"Harald F. Hess","orcid":"https://orcid.org/0000-0003-3000-1533"},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harald Hess","raw_affiliation_strings":["HHMI, Ashburn, VA, USA","HHMI, Ashburn, VA"],"affiliations":[{"raw_affiliation_string":"HHMI, Ashburn, VA, USA","institution_ids":["https://openalex.org/I195573530"]},{"raw_affiliation_string":"HHMI, Ashburn, VA","institution_ids":["https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018040690","display_name":"Richard D. Fetter","orcid":"https://orcid.org/0000-0002-1558-100X"},"institutions":[{"id":"https://openalex.org/I4210158120","display_name":"Swiss Epilepsy Center","ror":"https://ror.org/05xnnea38","country_code":"CH","type":"other","lineage":["https://openalex.org/I4210158120"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Richard Fetter","raw_affiliation_strings":["EPF Lausanne, Lausanne, Switzerland","HHMI, Ashburn, VA"],"affiliations":[{"raw_affiliation_string":"EPF Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210158120","https://openalex.org/I5124864"]},{"raw_affiliation_string":"HHMI, Ashburn, VA","institution_ids":["https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084059028","display_name":"Marco Cantoni","orcid":"https://orcid.org/0000-0002-1356-9541"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]},{"id":"https://openalex.org/I4210158120","display_name":"Swiss Epilepsy Center","ror":"https://ror.org/05xnnea38","country_code":"CH","type":"other","lineage":["https://openalex.org/I4210158120"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marco Cantoni","raw_affiliation_strings":["EPF Lausanne, Lausanne, Switzerland","[EPFL Lausanne]"],"affiliations":[{"raw_affiliation_string":"EPF Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210158120","https://openalex.org/I5124864"]},{"raw_affiliation_string":"[EPFL Lausanne]","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059529790","display_name":"Graham Knott","orcid":"https://orcid.org/0000-0002-2956-9052"},"institutions":[{"id":"https://openalex.org/I4210158120","display_name":"Swiss Epilepsy Center","ror":"https://ror.org/05xnnea38","country_code":"CH","type":"other","lineage":["https://openalex.org/I4210158120"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Graham Knott","raw_affiliation_strings":["EPF Lausanne, Lausanne, Switzerland","[EPFL Lausanne]"],"affiliations":[{"raw_affiliation_string":"EPF Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210158120","https://openalex.org/I5124864"]},{"raw_affiliation_string":"[EPFL Lausanne]","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062874541","display_name":"Dmitri B. Chklovskii","orcid":"https://orcid.org/0000-0002-4781-2546"},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitri Chklovskii","raw_affiliation_strings":["HHMI, Ashburn, VA, USA","HHMI, Ashburn, VA"],"affiliations":[{"raw_affiliation_string":"HHMI, Ashburn, VA, USA","institution_ids":["https://openalex.org/I195573530"]},{"raw_affiliation_string":"HHMI, Ashburn, VA","institution_ids":["https://openalex.org/I195573530"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5073971393"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9967,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.95303089,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"1767","last_page":"1774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14117","display_name":"Integrated Circuits and Semiconductor Failure Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14117","display_name":"Integrated Circuits and Semiconductor Failure Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6633191108703613},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.6373215913772583},{"id":"https://openalex.org/keywords/tomographic-reconstruction","display_name":"Tomographic reconstruction","score":0.6178405284881592},{"id":"https://openalex.org/keywords/resolution","display_name":"Resolution (logic)","score":0.6114628314971924},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.6045418977737427},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.52252197265625},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.5007481575012207},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.491384893655777},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4798990488052368},{"id":"https://openalex.org/keywords/tracing","display_name":"Tracing","score":0.4706387221813202},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.44608867168426514},{"id":"https://openalex.org/keywords/electron-tomography","display_name":"Electron tomography","score":0.4400915801525116},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4084951877593994},{"id":"https://openalex.org/keywords/electron-microscope","display_name":"Electron microscope","score":0.25918662548065186},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2326887845993042},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19270280003547668}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6633191108703613},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.6373215913772583},{"id":"https://openalex.org/C97742081","wikidata":"https://www.wikidata.org/wiki/Q7820109","display_name":"Tomographic reconstruction","level":3,"score":0.6178405284881592},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.6114628314971924},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.6045418977737427},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.52252197265625},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.5007481575012207},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.491384893655777},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4798990488052368},{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.4706387221813202},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.44608867168426514},{"id":"https://openalex.org/C75806775","wikidata":"https://www.wikidata.org/wiki/Q5358194","display_name":"Electron tomography","level":4,"score":0.4400915801525116},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4084951877593994},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.25918662548065186},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2326887845993042},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19270280003547668},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C193016168","wikidata":"https://www.wikidata.org/wiki/Q874835","display_name":"Scanning transmission electron microscopy","level":3,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cvpr.2010.5539846","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cvpr.2010.5539846","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.231.6389","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.231.6389","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cfar.umd.edu/%7Evashok/MyPapers/HighlySelectiveConf2010/EM_Tilts_IEEE_Compatiable.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1480179914","https://openalex.org/W1965637518","https://openalex.org/W1993673892","https://openalex.org/W2010161441","https://openalex.org/W2010389668","https://openalex.org/W2015418199","https://openalex.org/W2030449718","https://openalex.org/W2038665424","https://openalex.org/W2046778170","https://openalex.org/W2050834445","https://openalex.org/W2071284784","https://openalex.org/W2088256340","https://openalex.org/W2101675075","https://openalex.org/W2105436594","https://openalex.org/W2112050657","https://openalex.org/W2139302318","https://openalex.org/W2145096794","https://openalex.org/W2160547390","https://openalex.org/W2160938187","https://openalex.org/W2164452299","https://openalex.org/W2164595191","https://openalex.org/W2289917018","https://openalex.org/W2296616510","https://openalex.org/W4250955649","https://openalex.org/W6696163806"],"related_works":["https://openalex.org/W2018986990","https://openalex.org/W1993161289","https://openalex.org/W2982317495","https://openalex.org/W2555999489","https://openalex.org/W2088308468","https://openalex.org/W3038752912","https://openalex.org/W170151271","https://openalex.org/W2017732498","https://openalex.org/W2947117330","https://openalex.org/W2295596929"],"abstract_inverted_index":{"Future":[0],"progress":[1],"in":[2,41,58,91,126],"neuroscience":[3],"hinges":[4],"on":[5],"reconstruction":[6,132,166],"of":[7,13,17,20,79,116,151,157,167,173],"neuronal":[8,21,158],"circuits":[9,169],"to":[10,63,83,94,170],"the":[11,18,38,42,65,72,106,141,171],"level":[12,172],"individual":[14,174],"synapses.":[15,175],"Because":[16],"specifics":[19],"architecture,":[22],"imaging":[23],"must":[24],"be":[25,56,84,110],"done":[26],"with":[27,60],"very":[28,145],"high":[29,96,164],"resolution":[30,40,47,98],"and":[31],"throughput.":[32],"While":[33],"Electron":[34],"Microscopy":[35],"(EM)":[36],"achieves":[37],"required":[39],"transverse":[43],"directions,":[44],"its":[45],"depth":[46,66,97],"is":[48],"a":[49],"severe":[50],"limitation.":[51],"Computed":[52],"tomography":[53],"(CT)":[54],"may":[55],"used":[57],"conjunction":[59],"electron":[61],"microscopy":[62],"improve":[64],"resolution,":[67],"but":[68],"this":[69],"severely":[70],"limits":[71],"throughput":[73,165],"since":[74],"several":[75],"tens":[76],"or":[77],"hundreds":[78],"EM":[80,99],"images":[81,100],"need":[82],"acquired.":[85],"Here,":[86],"we":[87,103],"exploit":[88],"recent":[89],"advances":[90],"signal":[92],"processing":[93],"obtain":[95],"computationally.":[101],"First,":[102],"show":[104],"that":[105,120,138],"brain":[107,142],"tissue":[108,143],"can":[109,139],"represented":[111],"as":[112],"sparse":[113],"linear":[114],"combination":[115],"local":[117],"basis":[118],"functions":[119],"are":[121],"thin":[122],"membrane-like":[123],"structures":[124],"oriented":[125],"various":[127],"directions.":[128],"We":[129],"then":[130],"develop":[131],"techniques":[133],"inspired":[134],"by":[135],"compressive":[136],"sensing":[137],"reconstruct":[140],"from":[144],"few":[146],"(typically":[147],"5)":[148],"tomographic":[149],"views":[150],"each":[152],"section.":[153],"This":[154],"enables":[155],"tracing":[156],"connections":[159],"across":[160],"layers":[161],"and,":[162],"hence,":[163],"neural":[168]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
