{"id":"https://openalex.org/W4229720643","doi":"https://doi.org/10.1109/csb.2004.1332567","title":"Designing synthetic biological systems by multiple time scale networks","display_name":"Designing synthetic biological systems by multiple time scale networks","publication_year":2004,"publication_date":"2004-11-08","ids":{"openalex":"https://openalex.org/W4229720643","doi":"https://doi.org/10.1109/csb.2004.1332567"},"language":"en","primary_location":{"id":"doi:10.1109/csb.2004.1332567","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2004.1332567","pdf_url":null,"source":{"id":"https://openalex.org/S4363608884","display_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100387932","display_name":"Ruiqi Wang","orcid":"https://orcid.org/0000-0001-6369-6162"},"institutions":[{"id":"https://openalex.org/I133712593","display_name":"Osaka Sangyo University","ror":"https://ror.org/01h2m4f20","country_code":"JP","type":"education","lineage":["https://openalex.org/I133712593"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ruiqi Wang","raw_affiliation_strings":["Osaka Sangyo University, Osaka, Japan"],"affiliations":[{"raw_affiliation_string":"Osaka Sangyo University, Osaka, Japan","institution_ids":["https://openalex.org/I133712593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010981475","display_name":"J. Nakai","orcid":null},"institutions":[{"id":"https://openalex.org/I133712593","display_name":"Osaka Sangyo University","ror":"https://ror.org/01h2m4f20","country_code":"JP","type":"education","lineage":["https://openalex.org/I133712593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J. Nakai","raw_affiliation_strings":["Osaka Sangyo University, Osaka, Japan"],"affiliations":[{"raw_affiliation_string":"Osaka Sangyo University, Osaka, Japan","institution_ids":["https://openalex.org/I133712593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021994495","display_name":"Mitsuyasu Seo","orcid":null},"institutions":[{"id":"https://openalex.org/I133712593","display_name":"Osaka Sangyo University","ror":"https://ror.org/01h2m4f20","country_code":"JP","type":"education","lineage":["https://openalex.org/I133712593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuyasu Seo","raw_affiliation_strings":["Osaka Sangyo University, Osaka, Japan"],"affiliations":[{"raw_affiliation_string":"Osaka Sangyo University, Osaka, Japan","institution_ids":["https://openalex.org/I133712593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012283696","display_name":"Luonan Chen","orcid":"https://orcid.org/0000-0002-3960-0068"},"institutions":[{"id":"https://openalex.org/I133712593","display_name":"Osaka Sangyo University","ror":"https://ror.org/01h2m4f20","country_code":"JP","type":"education","lineage":["https://openalex.org/I133712593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Luonan Chen","raw_affiliation_strings":["Osaka Sangyo University, Osaka, Japan"],"affiliations":[{"raw_affiliation_string":"Osaka Sangyo University, Osaka, Japan","institution_ids":["https://openalex.org/I133712593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100387932"],"corresponding_institution_ids":["https://openalex.org/I133712593"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37813212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"705","last_page":"706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11347","display_name":"Neural Networks Stability and Synchronization","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viewpoints","display_name":"Viewpoints","score":0.7651100158691406},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.7256691455841064},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6412964463233948},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5590065121650696},{"id":"https://openalex.org/keywords/ranging","display_name":"Ranging","score":0.5160917639732361},{"id":"https://openalex.org/keywords/network-structure","display_name":"Network structure","score":0.45837143063545227},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.4171592593193054},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.3526538610458374},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.33089104294776917},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.2753032445907593},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23128819465637207},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.168072909116745},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0915079116821289},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.06862989068031311}],"concepts":[{"id":"https://openalex.org/C2776035091","wikidata":"https://www.wikidata.org/wiki/Q7928819","display_name":"Viewpoints","level":2,"score":0.7651100158691406},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.7256691455841064},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6412964463233948},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5590065121650696},{"id":"https://openalex.org/C115051666","wikidata":"https://www.wikidata.org/wiki/Q6522493","display_name":"Ranging","level":2,"score":0.5160917639732361},{"id":"https://openalex.org/C2988224531","wikidata":"https://www.wikidata.org/wiki/Q20830730","display_name":"Network structure","level":2,"score":0.45837143063545227},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.4171592593193054},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3526538610458374},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.33089104294776917},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.2753032445907593},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23128819465637207},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.168072909116745},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0915079116821289},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.06862989068031311},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/csb.2004.1332567","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2004.1332567","pdf_url":null,"source":{"id":"https://openalex.org/S4363608884","display_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2007673294"],"related_works":["https://openalex.org/W2385368906","https://openalex.org/W2902924992","https://openalex.org/W2626642044","https://openalex.org/W93537448","https://openalex.org/W2619807045","https://openalex.org/W2388758053","https://openalex.org/W2783354812","https://openalex.org/W4384112194","https://openalex.org/W2949734191","https://openalex.org/W2017333877"],"abstract_inverted_index":{"Rhythmic":[0],"phenomena":[1],"exist":[2],"in":[3,32,154],"living":[4],"organisms":[5],"at":[6],"all":[7],"levels":[8],"with":[9,61,90,134],"periods":[10],"ranging":[11],"from":[12],"less":[13],"than":[14],"a":[15,28,51,74,88,113,128],"second":[16],"to":[17,35,49,54,141],"years":[18],"[1].":[19,155],"From":[20],"both":[21,118],"theoretical":[22,144,148],"and":[23,38,56,79,120,137,149],"experiment":[24],"viewpoints,":[25],"it":[26,111],"is":[27,139],"great":[29],"challenging":[30],"problem":[31],"biological":[33,58],"science":[34],"model,":[36],"analyze":[37,55],"further":[39],"predict":[40],"the":[41,103,108,143],"periodic":[42,99],"behaviors":[43],"of":[44,73,107],"biosystems.":[45],"This":[46],"paper":[47],"aims":[48],"develop":[50],"new":[52],"methodology":[53],"design":[57],"oscillating":[59],"networks":[60,68,83],"time":[62,105],"delays,":[63],"by":[64],"using":[65],"multiple":[66,80],"time-scale":[67],"(MTN)":[69],"which":[70],"are":[71,152],"composed":[72],"cyclic":[75],"feedback":[76,82,122],"network":[77,115],"(CFN)":[78],"positive":[81,119],"(PFN).":[84],"We":[85],"show":[86],"that":[87],"MTN":[89],"certain":[91],"conditions":[92],"has":[93,112],"no":[94],"stable":[95,98],"equilibria":[96],"but":[97],"oscillations,":[100],"depending":[101],"on":[102],"total":[104],"delay":[106],"CFN,":[109],"although":[110],"complicated":[114],"structure":[116],"including":[117],"negative":[121],"loops.":[123],"As":[124],"an":[125],"implementation":[126],"example,":[127],"biologically":[129],"plausible":[130],"two-gene":[131],"synthetic":[132],"model":[133],"genes":[135],"lac":[136],"cI":[138],"designed":[140],"demonstrate":[142],"result.":[145],"The":[146],"detail":[147],"numerical":[150],"results":[151],"described":[153]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
