{"id":"https://openalex.org/W4237855682","doi":"https://doi.org/10.1109/csb.2004.1332550","title":"Structural analysis of FGFR1 kinase activation through molecular dynamics simulation","display_name":"Structural analysis of FGFR1 kinase activation through molecular dynamics simulation","publication_year":2004,"publication_date":"2004-11-08","ids":{"openalex":"https://openalex.org/W4237855682","doi":"https://doi.org/10.1109/csb.2004.1332550"},"language":"en","primary_location":{"id":"doi:10.1109/csb.2004.1332550","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2004.1332550","pdf_url":null,"source":{"id":"https://openalex.org/S4363608884","display_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","issn_l":"1752-7791","issn":["1752-7791"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100396031","display_name":"Peng Wang","orcid":"https://orcid.org/0000-0002-4534-2691"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Wang","raw_affiliation_strings":["Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062568388","display_name":"Zhengchang Su","orcid":"https://orcid.org/0000-0003-4636-3440"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengchang Su","raw_affiliation_strings":["Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103170888","display_name":"Jun\u2010tao Guo","orcid":"https://orcid.org/0000-0001-5949-8948"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juntao Guo","raw_affiliation_strings":["Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020171946","display_name":"Ying Xu","orcid":"https://orcid.org/0000-0002-7856-3343"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Xu","raw_affiliation_strings":["Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, University of Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39159198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"665","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.56995689868927},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"Protein kinase domain","score":0.5642277002334595},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5550129413604736},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5269813537597656},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"Fibroblast growth factor receptor","score":0.5180838108062744},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor-1","display_name":"Fibroblast growth factor receptor 1","score":0.49823427200317383},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.37932518124580383},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3404102623462677},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3404046893119812},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3262873888015747},{"id":"https://openalex.org/keywords/fibroblast-growth-factor","display_name":"Fibroblast growth factor","score":0.22366607189178467},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.22215747833251953},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1979655921459198},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09126889705657959}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.56995689868927},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.5642277002334595},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5550129413604736},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5269813537597656},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.5180838108062744},{"id":"https://openalex.org/C49418065","wikidata":"https://www.wikidata.org/wiki/Q14914258","display_name":"Fibroblast growth factor receptor 1","level":4,"score":0.49823427200317383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37932518124580383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3404102623462677},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3404046893119812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3262873888015747},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.22366607189178467},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22215747833251953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1979655921459198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09126889705657959},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/csb.2004.1332550","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2004.1332550","pdf_url":null,"source":{"id":"https://openalex.org/S4363608884","display_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","issn_l":"1752-7791","issn":["1752-7791"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306352","display_name":"Georgia Cancer Coalition","ror":"https://ror.org/0009gvn90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1994105285","https://openalex.org/W2103815459"],"related_works":["https://openalex.org/W4205487352","https://openalex.org/W3122394192","https://openalex.org/W4210477462","https://openalex.org/W4248721660","https://openalex.org/W2358034211","https://openalex.org/W2303460706","https://openalex.org/W2300520007","https://openalex.org/W4389224184","https://openalex.org/W2790400007","https://openalex.org/W2973192241"],"abstract_inverted_index":{"Receptor":[0],"tyrokine":[1],"kinases":[2],"are":[3],"critical":[4],"regulators":[5],"of":[6,38,42,78,86],"signal":[7],"transduction":[8],"pathways":[9],"mediating":[10],"cellular":[11],"homeostasis.":[12],"Enhanced":[13],"kinase":[14,40,69],"activities":[15],"via":[16],"mutation":[17],"and":[18,68],"other":[19],"genetic":[20],"alternations":[21],"have":[22],"been":[23],"observed":[24],"in":[25,83],"many":[26],"human":[27],"cancers.":[28],"We":[29],"performed":[30],"a":[31],"4":[32],"ns":[33],"molecular":[34],"dynamics":[35],"(MD)":[36],"simulation":[37,58],"the":[39,51,60,76,84],"domain":[41],"fibroblast":[43],"growth":[44],"factor":[45],"receptor":[46],"1":[47],"(FGFRl)":[48],"to":[49],"study":[50],"mechanism":[52],"that":[53,64],"controls":[54],"its":[55],"activation.":[56,70],"Our":[57],"revealed":[59],"key":[61],"atomic":[62],"events":[63],"allow":[65],"substrate":[66],"access":[67],"This":[71],"dynamic":[72],"information":[73],"will":[74],"facilitate":[75],"design":[77],"new":[79],"inhibitors":[80],"for":[81],"use":[82],"treatment":[85],"cancer.":[87]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
