{"id":"https://openalex.org/W2107195081","doi":"https://doi.org/10.1109/csb.2004.1332414","title":"Segmental duplications containing tandem repeated genes encoding putative deubiquitinating enzymes","display_name":"Segmental duplications containing tandem repeated genes encoding putative deubiquitinating enzymes","publication_year":2004,"publication_date":"2004-11-08","ids":{"openalex":"https://openalex.org/W2107195081","doi":"https://doi.org/10.1109/csb.2004.1332414","mag":"2107195081","pmid":"https://pubmed.ncbi.nlm.nih.gov/16447997"},"language":"en","primary_location":{"id":"doi:10.1109/csb.2004.1332414","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2004.1332414","pdf_url":null,"source":{"id":"https://openalex.org/S4363608884","display_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100410334","display_name":"Hong Liu","orcid":"https://orcid.org/0000-0002-8926-1308"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Aventis Pharmaceuticals Inc., Bridgewater, NJ 08807, USA. hong.liu@aventis.com"],"affiliations":[{"raw_affiliation_string":"Aventis Pharmaceuticals Inc., Bridgewater, NJ 08807, USA. hong.liu@aventis.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361352","display_name":"Li Li","orcid":"https://orcid.org/0000-0003-2459-3499"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["Aventis Pharmaceuticals, Inc., Bridgewater, NJ, USA"],"affiliations":[{"raw_affiliation_string":"Aventis Pharmaceuticals, Inc., Bridgewater, NJ, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028367326","display_name":"Asher Zilberstein","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Zilberstein","raw_affiliation_strings":["Aventis Pharmaceuticals, Inc., Bridgewater, NJ, USA"],"affiliations":[{"raw_affiliation_string":"Aventis Pharmaceuticals, Inc., Bridgewater, NJ, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111464572","display_name":"Chang S. Hahn","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.S. Hahn","raw_affiliation_strings":["Aventis Pharmaceuticals, Inc., Bridgewater, NJ, USA"],"affiliations":[{"raw_affiliation_string":"Aventis Pharmaceuticals, Inc., Bridgewater, NJ, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100410334"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14285714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":null,"first_page":"28","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7614189982414246},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7575787901878357},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.7335143089294434},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6837478876113892},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6588460803031921},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.526507556438446},{"id":"https://openalex.org/keywords/segmental-duplication","display_name":"Segmental duplication","score":0.5014865398406982},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.4943976402282715},{"id":"https://openalex.org/keywords/chromosome-21","display_name":"Chromosome 21","score":0.43909144401550293},{"id":"https://openalex.org/keywords/gene-cluster","display_name":"Gene cluster","score":0.4332966208457947},{"id":"https://openalex.org/keywords/gene-family","display_name":"Gene family","score":0.35705268383026123}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7614189982414246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7575787901878357},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.7335143089294434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6837478876113892},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6588460803031921},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.526507556438446},{"id":"https://openalex.org/C57808653","wikidata":"https://www.wikidata.org/wiki/Q7446270","display_name":"Segmental duplication","level":5,"score":0.5014865398406982},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4943976402282715},{"id":"https://openalex.org/C137555145","wikidata":"https://www.wikidata.org/wiki/Q753218","display_name":"Chromosome 21","level":4,"score":0.43909144401550293},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.4332966208457947},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.35705268383026123}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044764","descriptor_name":"Ubiquitin-Activating Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044764","descriptor_name":"Ubiquitin-Activating Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044764","descriptor_name":"Ubiquitin-Activating Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/csb.2004.1332414","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2004.1332414","pdf_url":null,"source":{"id":"https://openalex.org/S4363608884","display_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004.","raw_type":"proceedings-article"},{"id":"pmid:16447997","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16447997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE Computational Systems Bioinformatics Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life in Land","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1551836412","https://openalex.org/W1569753455","https://openalex.org/W1964918240","https://openalex.org/W1968150615","https://openalex.org/W2003209070","https://openalex.org/W2005861201","https://openalex.org/W2045040686","https://openalex.org/W2055043387","https://openalex.org/W2105552887","https://openalex.org/W2106882534","https://openalex.org/W2116969739","https://openalex.org/W2129336823","https://openalex.org/W2132998124","https://openalex.org/W2166187656","https://openalex.org/W2168909179","https://openalex.org/W4236236547"],"related_works":["https://openalex.org/W1914610732","https://openalex.org/W4236246458","https://openalex.org/W1970221653","https://openalex.org/W3121625551","https://openalex.org/W2967985428","https://openalex.org/W1997434888","https://openalex.org/W4292264726","https://openalex.org/W2155919888","https://openalex.org/W2184689983","https://openalex.org/W2229695611"],"abstract_inverted_index":{"Both":[0],"inter-":[1,170],"and":[2,47,70,121,126,161,171,180],"intra-chromosomal":[3,172],"segmental":[4,188],"duplications":[5],"are":[6,51,64,99,115,140],"known":[7],"occurred":[8],"in":[9,66,142,149,167],"human":[10,29],"genome":[11],"during":[12],"evolution.":[13],"Few":[14],"cases":[15],"of":[16,31,41,85,112,178,186],"such":[17],"segments":[18,156],"involving":[19],"functional":[20],"genes":[21,43,63,132],"have":[22,91],"been":[23,195],"reported.":[24],"While":[25],"searching":[26],"for":[27,130],"the":[28,59,82,108,136,143,155,176,187],"orthologs":[30],"murine":[32],"hematopoietic":[33],"deubiquitinating":[34],"enzymes":[35],"(DUBs),":[36],"we":[37,90],"identified":[38,92],"four":[39],"clusters":[40,75,160],"DUB-like":[42,131],"on":[44,118],"chromosome":[45,48,119,122],"4p15":[46],"8p22-23":[49],"that":[50,98,154],"over":[52],"90%":[53],"identical":[54],"to":[55,104],"each":[56],"other":[57],"at":[58],"DNA":[60],"level.":[61],"These":[62],"expressed":[65],"a":[67],"cell":[68],"type-":[69],"activation-specific":[71],"manner,":[72],"with":[73],"different":[74],"possessing":[76],"potentially":[77],"distinct":[78],"expression":[79],"profiles.":[80],"Examining":[81],"surrounding":[83,137,162],"sequences":[84,129],"these":[86,113,158],"gene":[87,109,192],"duplication":[88,189],"events,":[89],"previously":[93],"unreported":[94],"conserved":[95,138],"sequence":[96],"elements":[97,114,163],"as":[100,102,133,135],"large":[101],"35":[103],"74":[105],"kb":[106],"encircling":[107],"clusters.":[110],"Traces":[111],"also":[116],"found":[117],"12p13":[120],"11q13.":[123],"The":[124],"coding":[125],"immediate":[127],"upstream":[128],"well":[134],"elements,":[139],"present":[141],"chimpanzee":[144],"trace":[145],"database,":[146],"but":[147],"not":[148],"rodent":[150],"genome.":[151],"We":[152],"hypothesize":[153],"containing":[157,190],"DUB":[159],"arose":[164],"relatively":[165],"recently":[166],"evolution":[168],"through":[169],"duplicative":[173],"transpositions,":[174],"following":[175],"divergence":[177],"primates":[179],"rodents.":[181],"Genome":[182],"wide":[183],"systematical":[184],"search":[185],"duplicated":[191],"cluster":[193],"has":[194],"performed.":[196]},"counts_by_year":[],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}