{"id":"https://openalex.org/W1488245110","doi":"https://doi.org/10.1109/csb.2003.1227428","title":"Noise-attenuation in artificial genetic networks","display_name":"Noise-attenuation in artificial genetic networks","publication_year":2004,"publication_date":"2004-03-30","ids":{"openalex":"https://openalex.org/W1488245110","doi":"https://doi.org/10.1109/csb.2003.1227428","mag":"1488245110"},"language":"en","primary_location":{"id":"doi:10.1109/csb.2003.1227428","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2003.1227428","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031984998","display_name":"Yoshihiro Morishita","orcid":"https://orcid.org/0000-0002-1095-5949"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Y. Morishita","raw_affiliation_strings":["Department of Complexity Science and Engineeing, University of Tokyo, Tokyo, Japan","Dept. of Complexity Sci. & Eng., Tokyo Univ., Japan#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Complexity Science and Engineeing, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Dept. of Complexity Sci. & Eng., Tokyo Univ., Japan#TAB#","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038078845","display_name":"Kazuyuki Aihara","orcid":"https://orcid.org/0000-0002-4602-9816"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Aihara","raw_affiliation_strings":["Department of Complexity Science and Engineeing, University of Tokyo, Tokyo, Japan","Dept. of Complexity Sci. & Eng., Tokyo Univ., Japan#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Complexity Science and Engineeing, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Dept. of Complexity Sci. & Eng., Tokyo Univ., Japan#TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031984998"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03641808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"403","issue":null,"first_page":"629","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9767000079154968,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.6586673259735107},{"id":"https://openalex.org/keywords/attenuation","display_name":"Attenuation","score":0.6457000374794006},{"id":"https://openalex.org/keywords/genetic-network","display_name":"Genetic network","score":0.5759665369987488},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.5318154096603394},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4952775537967682},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4418126940727234},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.33840543031692505},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.31806594133377075},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20057177543640137},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18649300932884216},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.13736161589622498},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10119929909706116},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.08603766560554504}],"concepts":[{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.6586673259735107},{"id":"https://openalex.org/C184652730","wikidata":"https://www.wikidata.org/wiki/Q2357982","display_name":"Attenuation","level":2,"score":0.6457000374794006},{"id":"https://openalex.org/C2986044853","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Genetic network","level":3,"score":0.5759665369987488},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.5318154096603394},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4952775537967682},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4418126940727234},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33840543031692505},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31806594133377075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20057177543640137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18649300932884216},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.13736161589622498},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10119929909706116},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08603766560554504},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/csb.2003.1227428","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2003.1227428","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1968856189","https://openalex.org/W2102787760","https://openalex.org/W2134759932","https://openalex.org/W2155418451","https://openalex.org/W2484638602"],"related_works":["https://openalex.org/W2062605435","https://openalex.org/W2273182195","https://openalex.org/W2186374051","https://openalex.org/W2377963109","https://openalex.org/W2022279172","https://openalex.org/W2352247021","https://openalex.org/W2145835458","https://openalex.org/W2059332403","https://openalex.org/W2767089762","https://openalex.org/W2066034608"],"abstract_inverted_index":{"Dynamics":[0],"of":[1,8,15,18,60],"gene":[2,103],"expressions":[3],"is":[4,57],"quite":[5],"noisy":[6],"because":[7],"intrinsic":[9],"noise":[10],"originated":[11],"from":[12,88],"the":[13,16,61,80,86,89],"smallness":[14],"number":[17],"related":[19],"molecules.":[20],"Noise-attenuation":[21],"and":[22,36,79,83],"system-stabilization":[23],"in":[24,34,50],"artificial":[25,51],"genetic":[26,52],"networks":[27],"are":[28],"important":[29],"problems":[30],"for":[31,85],"various":[32],"applications":[33],"engineering":[35],"medical":[37],"areas.":[38],"In":[39],"this":[40,95],"study,":[41],"we":[42,97],"propose":[43],"a":[44],"plausible":[45],"method":[46],"to":[47,64,67],"control":[48],"fluctuation":[49],"networks.":[53],"The":[54],"main":[55],"idea":[56],"an":[58],"addition":[59],"molecules":[62,78],"designed":[63],"specifically":[65],"bind":[66],"synthesized":[68],"proteins":[69,81],"with":[70,109],"fast":[71,74],"equilibrium.":[72],"This":[73],"interaction":[75],"between":[76],"those":[77],"absorbs":[82],"compensates":[84],"variation":[87],"average.":[90],"We":[91],"demonstrate":[92],"that,":[93],"by":[94],"method,":[96],"can":[98],"stabilize":[99],"not":[100],"only":[101],"single":[102],"expression,":[104],"but":[105],"also":[106],"system":[107],"dynamics":[108],"multistable":[110],"states.":[111]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}