{"id":"https://openalex.org/W2143121368","doi":"https://doi.org/10.1109/csb.2003.1227374","title":"Computational simulation of lipid bilayer reorientation at gaps","display_name":"Computational simulation of lipid bilayer reorientation at gaps","publication_year":2004,"publication_date":"2004-03-30","ids":{"openalex":"https://openalex.org/W2143121368","doi":"https://doi.org/10.1109/csb.2003.1227374","mag":"2143121368"},"language":"en","primary_location":{"id":"doi:10.1109/csb.2003.1227374","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2003.1227374","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081016259","display_name":"Peter M. Kasson","orcid":"https://orcid.org/0000-0002-3111-8103"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P.M. Kasson","raw_affiliation_strings":["Med. Scientist Training Program, Stanford Univ., CA, USA"],"affiliations":[{"raw_affiliation_string":"Med. Scientist Training Program, Stanford Univ., CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032418986","display_name":"Vijay S. Pande","orcid":"https://orcid.org/0000-0003-2774-1178"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay S Pande","raw_affiliation_strings":["Stanford University"],"affiliations":[{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081016259"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11024967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"464","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-bilayer-fusion","display_name":"Lipid bilayer fusion","score":0.7893949747085571},{"id":"https://openalex.org/keywords/lipid-bilayer","display_name":"Lipid bilayer","score":0.7232128381729126},{"id":"https://openalex.org/keywords/bilayer","display_name":"Bilayer","score":0.7088030576705933},{"id":"https://openalex.org/keywords/exocytosis","display_name":"Exocytosis","score":0.6538084745407104},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5254035592079163},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5190087556838989},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.464688777923584},{"id":"https://openalex.org/keywords/phospholipid","display_name":"Phospholipid","score":0.41019344329833984},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.408441960811615},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4053340256214142},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.3541640639305115},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3132944107055664},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20552626252174377},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10667714476585388},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.08565062284469604}],"concepts":[{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.7893949747085571},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.7232128381729126},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7088030576705933},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.6538084745407104},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5254035592079163},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5190087556838989},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.464688777923584},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.41019344329833984},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.408441960811615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4053340256214142},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3541640639305115},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3132944107055664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20552626252174377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10667714476585388},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.08565062284469604}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/csb.2003.1227374","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2003.1227374","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1972757296","https://openalex.org/W1977059850","https://openalex.org/W1988088765","https://openalex.org/W1995247662","https://openalex.org/W2003329164","https://openalex.org/W2009976708","https://openalex.org/W2018848326","https://openalex.org/W2018942194","https://openalex.org/W2041653006","https://openalex.org/W2042332534","https://openalex.org/W2048338470","https://openalex.org/W2063043902","https://openalex.org/W2065464482","https://openalex.org/W2078641573","https://openalex.org/W2091812444","https://openalex.org/W2106140689","https://openalex.org/W2156871002","https://openalex.org/W2160679445"],"related_works":["https://openalex.org/W1535881221","https://openalex.org/W1967756787","https://openalex.org/W2006158152","https://openalex.org/W2154233705","https://openalex.org/W2389992822","https://openalex.org/W1949197459","https://openalex.org/W2737987188","https://openalex.org/W1601243998","https://openalex.org/W2061481432","https://openalex.org/W2061491052"],"abstract_inverted_index":{"Understanding":[0],"cellular":[1],"membrane":[2,30,111],"processes":[3],"is":[4],"critical":[5],"for":[6,28],"the":[7,33,55,75,121],"study":[8],"of":[9,36,57,61,70,77,94,115,124],"events":[10],"such":[11,126],"as":[12,24,127],"viral":[13],"entry,":[14],"neurotransmitter":[15],"exocytosis,":[16],"and":[17,42,80,85,92,129],"immune":[18],"activation.":[19],"Supported":[20],"lipid":[21],"bilayers":[22,72],"serve":[23],"a":[25,58],"model":[26,60,74],"system":[27],"many":[29,39],"processes.":[31,63],"Despite":[32],"relative":[34],"simplicity":[35],"this":[37],"system,":[38],"important":[40],"structural":[41],"dynamic":[43],"parameters":[44],"are":[45],"not":[46],"experimentally":[47],"observable":[48],"with":[49],"current":[50],"techniques.":[51],"Computational":[52],"approaches":[53],"allow":[54],"development":[56],"high-resolution":[59],"bilayer":[62,78,98],"We":[64],"have":[65],"performed":[66],"molecular":[67],"dynamics":[68],"simulations":[69,88],"phospholipid":[71],"to":[73,81,120],"creation":[76],"gaps":[79],"analyze":[82],"their":[83],"structure":[84],"dynamics.":[86],"Our":[87],"show":[89],"rapid":[90,107],"reorientation":[91],"movement":[93],"phospholipids":[95],"near":[96],"simulated":[97],"edges.":[99],"These":[100],"data":[101],"suggest":[102],"that":[103],"lipids":[104],"may":[105],"undergo":[106],"local":[108],"rearrangements":[109],"during":[110],"fusion,":[112],"facilitating":[113],"formation":[114],"fusion":[116],"intermediates":[117],"thought":[118],"key":[119],"infection":[122],"cycle":[123],"viruses":[125],"influenza":[128],"HIV.":[130]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}