{"id":"https://openalex.org/W1492280848","doi":"https://doi.org/10.1109/csb.2003.1227288","title":"Keynote address: the role of algorithmic research in computational genomics","display_name":"Keynote address: the role of algorithmic research in computational genomics","publication_year":2004,"publication_date":"2004-03-23","ids":{"openalex":"https://openalex.org/W1492280848","doi":"https://doi.org/10.1109/csb.2003.1227288","mag":"1492280848","pmid":"https://pubmed.ncbi.nlm.nih.gov/16826642"},"language":"en","primary_location":{"id":"doi:10.1109/csb.2003.1227288","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2003.1227288","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068875104","display_name":"Richard M. Karp","orcid":null},"institutions":[{"id":"https://openalex.org/I1297971548","display_name":"International Computer Science Institute","ror":"https://ror.org/01ewh7m12","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1297971548"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R.M. Karp","raw_affiliation_strings":["International Computer Science Institute, University of California Berkeley, Berkeley, CA, USA","California Univ., Berkeley, CA USA"],"affiliations":[{"raw_affiliation_string":"International Computer Science Institute, University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I1297971548","https://openalex.org/I95457486"]},{"raw_affiliation_string":"California Univ., Berkeley, CA USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068875104"],"corresponding_institution_ids":["https://openalex.org/I1297971548","https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":0.4678,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59065269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":null,"first_page":"10","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9656999707221985,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.9567999839782715,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6960476636886597},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.5963218212127686},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.5806030631065369},{"id":"https://openalex.org/keywords/frame","display_name":"Frame (networking)","score":0.5567384958267212},{"id":"https://openalex.org/keywords/computational-genomics","display_name":"Computational genomics","score":0.5314986109733582},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5025632381439209},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.483924925327301},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.33360838890075684},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3206337094306946},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13744503259658813},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.07185548543930054}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6960476636886597},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.5963218212127686},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.5806030631065369},{"id":"https://openalex.org/C126042441","wikidata":"https://www.wikidata.org/wiki/Q1324888","display_name":"Frame (networking)","level":2,"score":0.5567384958267212},{"id":"https://openalex.org/C39238701","wikidata":"https://www.wikidata.org/wiki/Q2091816","display_name":"Computational genomics","level":5,"score":0.5314986109733582},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5025632381439209},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.483924925327301},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.33360838890075684},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3206337094306946},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13744503259658813},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.07185548543930054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/csb.2003.1227288","is_oa":false,"landing_page_url":"https://doi.org/10.1109/csb.2003.1227288","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003","raw_type":"proceedings-article"},{"id":"pmid:16826642","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16826642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE Computer Society Bioinformatics Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4","score":0.6700000166893005}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2226172145","https://openalex.org/W2935703330","https://openalex.org/W185100777","https://openalex.org/W2606645708","https://openalex.org/W2385787406","https://openalex.org/W1968252650","https://openalex.org/W3047052167","https://openalex.org/W3127469524","https://openalex.org/W4384571918","https://openalex.org/W3212428388"],"abstract_inverted_index":{"In":[0,74],"the":[1,13,36,41,48,93,104,110,114],"early":[2],"1990s,":[3],"after":[4],"more":[5],"than":[6],"three":[7],"decades":[8],"of":[9,16,38,51,95,103,112,133],"studying":[10],"algorithms":[11,39],"within":[12],"frame":[14],"work":[15],"theoretical":[17,45],"computer":[18,46,118],"science,":[19],"I":[20,82,99,106],"shifted":[21],"my":[22,88],"focus":[23],"to":[24,76,85,90],"alogrithmic":[25],"problems":[26],"arising":[27],"in":[28,40,44,57,60,79,109,130],"genomics.":[29],"There":[30],"is":[31,54,65],"a":[32,67,131],"fundamental":[33],"difference":[34],"between":[35],"views":[37],"two":[42],"fields:":[43],"science":[47],"input-output":[49],"behavior":[50],"an":[52,63],"algorithm":[53,64],"rigorously":[55],"specified":[56],"advance,":[58],"whereas":[59],"computational":[61,80],"biology":[62],"merely":[66],"vehicle":[68],"for":[69,117],"discovering":[70],"Nature's":[71],"ground":[72],"truth.":[73],"order":[75],"be":[77,128],"effective":[78],"genomics":[81],"have":[83,107],"had":[84],"radically":[86],"change":[87],"approach":[89],"research.":[91],"On":[92],"occasion":[94],"this":[96,123],"keynote":[97],"address":[98],"will":[100,127],"share":[101],"some":[102],"lessons":[105,126],"learned,":[108],"hope":[111],"making":[113],"way":[115],"easier":[116],"scientists":[119],"and":[120],"mathematicians":[121],"entering":[122],"field.":[124],"These":[125],"encapsulated":[129],"list":[132],"aphorisms,":[134],"accompanied":[135],"by":[136],"illustrative":[137],"examples.":[138]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}