{"id":"https://openalex.org/W4387914154","doi":"https://doi.org/10.1109/codit58514.2023.10284210","title":"Macroscopic Dynamic Modeling of Metabolic Shift to Lactate Consumption of Mammalian Cell Batch Cultures","display_name":"Macroscopic Dynamic Modeling of Metabolic Shift to Lactate Consumption of Mammalian Cell Batch Cultures","publication_year":2023,"publication_date":"2023-07-03","ids":{"openalex":"https://openalex.org/W4387914154","doi":"https://doi.org/10.1109/codit58514.2023.10284210"},"language":"en","primary_location":{"id":"doi:10.1109/codit58514.2023.10284210","is_oa":false,"landing_page_url":"https://doi.org/10.1109/codit58514.2023.10284210","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 9th International Conference on Control, Decision and Information Technologies (CoDIT)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091102756","display_name":"Guilherme A. Pimentel","orcid":"https://orcid.org/0000-0001-9135-0927"},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Guilherme A. Pimentel","raw_affiliation_strings":["University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000"],"affiliations":[{"raw_affiliation_string":"University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079070585","display_name":"Laurent Dewasme","orcid":"https://orcid.org/0000-0002-1688-167X"},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laurent Dewasme","raw_affiliation_strings":["University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000"],"affiliations":[{"raw_affiliation_string":"University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059675822","display_name":"Fernando N. Santos-Navarro","orcid":"https://orcid.org/0000-0003-2710-8612"},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fernando N. Santos-Navarro","raw_affiliation_strings":["University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000"],"affiliations":[{"raw_affiliation_string":"University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041083563","display_name":"Adrien Boes","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162365","display_name":"Centre d\u2019Economie rurale","ror":"https://ror.org/05bh7ff72","country_code":"BE","type":"education","lineage":["https://openalex.org/I4210162365"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Adrien Boes","raw_affiliation_strings":["CER Groupe,Biotechnology Department,Aye,Belgium,6900"],"affiliations":[{"raw_affiliation_string":"CER Groupe,Biotechnology Department,Aye,Belgium,6900","institution_ids":["https://openalex.org/I4210162365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017862703","display_name":"F. Cote","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162365","display_name":"Centre d\u2019Economie rurale","ror":"https://ror.org/05bh7ff72","country_code":"BE","type":"education","lineage":["https://openalex.org/I4210162365"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois C\u00f4te","raw_affiliation_strings":["CER Groupe,Biotechnology Department,Aye,Belgium,6900"],"affiliations":[{"raw_affiliation_string":"CER Groupe,Biotechnology Department,Aye,Belgium,6900","institution_ids":["https://openalex.org/I4210162365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070954948","display_name":"Patrice Fil\u00e9e","orcid":"https://orcid.org/0000-0001-6523-1537"},"institutions":[{"id":"https://openalex.org/I4210162365","display_name":"Centre d\u2019Economie rurale","ror":"https://ror.org/05bh7ff72","country_code":"BE","type":"education","lineage":["https://openalex.org/I4210162365"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Patrice Fil\u00e9e","raw_affiliation_strings":["CER Groupe,Biotechnology Department,Aye,Belgium,6900"],"affiliations":[{"raw_affiliation_string":"CER Groupe,Biotechnology Department,Aye,Belgium,6900","institution_ids":["https://openalex.org/I4210162365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030337733","display_name":"Alain Vande Wouwer","orcid":"https://orcid.org/0000-0001-7022-6126"},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alain Vande Wouwer","raw_affiliation_strings":["University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000"],"affiliations":[{"raw_affiliation_string":"University of Mons,Systems, Estimation, Control and Optimization Group,Mons,Belgium,7000","institution_ids":["https://openalex.org/I130929987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5091102756"],"corresponding_institution_ids":["https://openalex.org/I130929987"],"apc_list":null,"apc_paid":null,"fwci":0.7921,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.7397255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.6704221963882446},{"id":"https://openalex.org/keywords/consumption","display_name":"Consumption (sociology)","score":0.5162289142608643},{"id":"https://openalex.org/keywords/biomass","display_name":"Biomass (ecology)","score":0.49744608998298645},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.49366697669029236},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4749293923377991},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4524553716182709},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4175226390361786},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3897284269332886},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3072124719619751}],"concepts":[{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6704221963882446},{"id":"https://openalex.org/C30772137","wikidata":"https://www.wikidata.org/wiki/Q5164762","display_name":"Consumption (sociology)","level":2,"score":0.5162289142608643},{"id":"https://openalex.org/C115540264","wikidata":"https://www.wikidata.org/wiki/Q2945560","display_name":"Biomass (ecology)","level":2,"score":0.49744608998298645},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.49366697669029236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4749293923377991},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4524553716182709},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4175226390361786},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3897284269332886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3072124719619751},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/codit58514.2023.10284210","is_oa":false,"landing_page_url":"https://doi.org/10.1109/codit58514.2023.10284210","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 9th International Conference on Control, Decision and Information Technologies (CoDIT)","raw_type":"proceedings-article"},{"id":"pmh:oai:orbi.umons.ac.be:20.500.12907/46828","is_oa":false,"landing_page_url":"https://orbi.umons.ac.be/handle/20.500.12907/46828","pdf_url":null,"source":{"id":"https://openalex.org/S7407055454","display_name":"ORBi UMONS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2023 9th International Conference on Control, Decision and Information Technologies (CoDIT), Rome, Ita [Ita], 03-07-2023 => 06-07-2023","raw_type":"peer reviewed"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1540596182","https://openalex.org/W2028115939","https://openalex.org/W2034451137","https://openalex.org/W2060959034","https://openalex.org/W2071646337","https://openalex.org/W2077779831","https://openalex.org/W2094382594","https://openalex.org/W2154571764","https://openalex.org/W2480960547","https://openalex.org/W2589500477","https://openalex.org/W2762440986","https://openalex.org/W2895577967","https://openalex.org/W2999957719","https://openalex.org/W4301667260","https://openalex.org/W6632267817","https://openalex.org/W6744593227"],"related_works":["https://openalex.org/W613780472","https://openalex.org/W4210347497","https://openalex.org/W1997864015","https://openalex.org/W2363394879","https://openalex.org/W3019067641","https://openalex.org/W391701938","https://openalex.org/W2349491863","https://openalex.org/W2313361601","https://openalex.org/W2352593301","https://openalex.org/W3216850291"],"abstract_inverted_index":{"A":[0],"macroscopic":[1,30,34],"model":[2,31,77,89,116],"that":[3,130],"considers":[4],"the":[5,14,64,92,114,126],"shift":[6],"to":[7,12,62],"lactate":[8,40,43,105,134],"consumption":[9,38,101],"is":[10,118],"proposed":[11,115],"simulate":[13],"therapeutic":[15],"proteins":[16],"produced":[17],"by":[18],"mammalian":[19,127],"cells":[20,26],"using":[21],"human":[22],"embryonic":[23],"kidney":[24],"293":[25],"(HEK293-6E)":[27],"cultures.":[28],"The":[29,53,76,88],"contains":[32],"four":[33,73],"reactions:":[35],"(i)":[36],"substrate":[37,100],"and":[39,48,79,98,103,107,109],"production,":[41],"(ii)":[42],"consumption,":[44,108],"(iii)":[45],"biomass":[46,51],"death,":[47,99],"(iv)":[49],"viable":[50],"maintenance.":[52],"maximum":[54],"likelihood":[55],"principal":[56],"component":[57],"analysis":[58],"has":[59],"been":[60],"used":[61],"extract":[63],"number":[65],"of":[66,95,125],"reactions":[67],"from":[68],"experimental":[69],"data":[70],"collected":[71],"in":[72],"batch":[74],"experiments.":[75],"parameters":[78],"confidence":[80],"intervals":[81],"are":[82],"obtained":[83],"via":[84],"nonlinear":[85],"least-squares":[86],"identification.":[87],"successfully":[90],"predicts":[91],"dynamic":[93],"behavior":[94],"cell":[96,128],"growth":[97],"(glucose":[102],"glutamine),":[104],"production":[106],"protein":[110],"production.":[111],"In":[112],"addition,":[113],"structure":[117],"also":[119],"validated":[120],"as":[121],"a":[122],"generalized":[123],"representation":[124],"cultures":[129],"do":[131],"not":[132],"present":[133],"consumption.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-07T16:01:11.037858","created_date":"2025-10-10T00:00:00"}