{"id":"https://openalex.org/W4387914560","doi":"https://doi.org/10.1109/codit58514.2023.10284208","title":"Model of Eukaryotic Cell Protein Control Schemes via Manufacturing System Simulator","display_name":"Model of Eukaryotic Cell Protein Control Schemes via Manufacturing System Simulator","publication_year":2023,"publication_date":"2023-07-03","ids":{"openalex":"https://openalex.org/W4387914560","doi":"https://doi.org/10.1109/codit58514.2023.10284208"},"language":"en","primary_location":{"id":"doi:10.1109/codit58514.2023.10284208","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/codit58514.2023.10284208","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 9th International Conference on Control, Decision and Information Technologies (CoDIT)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057136098","display_name":"Esha Ranade","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Esha Ranade","raw_affiliation_strings":["Massachusetts Institute of Technology,Department of Engineering,Cambridge,United States","Department of Engineering, Massachusetts Institute of Technology, Cambridge, United States"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Department of Engineering,Cambridge,United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Engineering, Massachusetts Institute of Technology, Cambridge, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086357201","display_name":"Fabio Fruggiero","orcid":"https://orcid.org/0000-0001-9412-6605"},"institutions":[{"id":"https://openalex.org/I20272500","display_name":"University of Basilicata","ror":"https://ror.org/03tc05689","country_code":"IT","type":"education","lineage":["https://openalex.org/I20272500"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Fruggiero","raw_affiliation_strings":["University of Basilicata,Department of Engineering,Potenza,Italy","Department of Engineering, University of Basilicata, Potenza, Italy"],"affiliations":[{"raw_affiliation_string":"University of Basilicata,Department of Engineering,Potenza,Italy","institution_ids":["https://openalex.org/I20272500"]},{"raw_affiliation_string":"Department of Engineering, University of Basilicata, Potenza, Italy","institution_ids":["https://openalex.org/I20272500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054886494","display_name":"Carmen Del Vecchio","orcid":"https://orcid.org/0000-0001-6937-9678"},"institutions":[{"id":"https://openalex.org/I16337185","display_name":"University of Sannio","ror":"https://ror.org/04vc81p87","country_code":"IT","type":"education","lineage":["https://openalex.org/I16337185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmen Del Vecchio","raw_affiliation_strings":["University of Sannio,Department of Engineering,Benevento,Italy","Department of Engineering, University of Sannio, Benevento, Italy"],"affiliations":[{"raw_affiliation_string":"University of Sannio,Department of Engineering,Benevento,Italy","institution_ids":["https://openalex.org/I16337185"]},{"raw_affiliation_string":"Department of Engineering, University of Sannio, Benevento, Italy","institution_ids":["https://openalex.org/I16337185"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057136098"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31707317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":null,"first_page":"1624","last_page":"1629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"Endoplasmic reticulum","score":0.7822448015213013},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"Unfolded protein response","score":0.7820326089859009},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5162774920463562},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.5160198211669922},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.51335209608078},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4777640402317047},{"id":"https://openalex.org/keywords/autoregulation","display_name":"Autoregulation","score":0.43826696276664734},{"id":"https://openalex.org/keywords/stress","display_name":"Stress (linguistics)","score":0.4323290288448334},{"id":"https://openalex.org/keywords/process-control","display_name":"Process control","score":0.4260004460811615},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3077552914619446},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2647857069969177},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21036982536315918},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.10335025191307068}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7822448015213013},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7820326089859009},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5162774920463562},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5160198211669922},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.51335209608078},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4777640402317047},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.43826696276664734},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.4323290288448334},{"id":"https://openalex.org/C155386361","wikidata":"https://www.wikidata.org/wiki/Q1649571","display_name":"Process control","level":3,"score":0.4260004460811615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3077552914619446},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2647857069969177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21036982536315918},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.10335025191307068},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/codit58514.2023.10284208","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/codit58514.2023.10284208","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 9th International Conference on Control, Decision and Information Technologies (CoDIT)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.unibas.it:11563/173920","is_oa":false,"landing_page_url":"https://hdl.handle.net/11563/173920","pdf_url":null,"source":{"id":"https://openalex.org/S4377196360","display_name":"CINECA IRIS Institutional Research Information System (University of Basilicata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20272500","host_organization_name":"University of Basilicata","host_organization_lineage":["https://openalex.org/I20272500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W338168858","https://openalex.org/W1977603207","https://openalex.org/W1988251214","https://openalex.org/W2005777386","https://openalex.org/W2093535002","https://openalex.org/W2097939652","https://openalex.org/W2102154359","https://openalex.org/W2129722310","https://openalex.org/W2140340914","https://openalex.org/W2163721561","https://openalex.org/W2766900039","https://openalex.org/W2913596958","https://openalex.org/W2921077614","https://openalex.org/W4296301619"],"related_works":["https://openalex.org/W1965514223","https://openalex.org/W4390033782","https://openalex.org/W2090107439","https://openalex.org/W2115706326","https://openalex.org/W2260493136","https://openalex.org/W2113188411","https://openalex.org/W2976965029","https://openalex.org/W2382178265","https://openalex.org/W2055827177","https://openalex.org/W2072666835"],"abstract_inverted_index":{"The":[0,149],"folding":[1],"and":[2,43,57,72,108,114,130,142,163],"transport":[3],"of":[4,11,45,62,70,75,111,127,155,173],"proteins":[5],"in":[6,20,92,105,116,146],"the":[7,38,51,60,68,73,76,101,106,109,112,125,128,132,137,143,147,153,157,170,174],"Endoplasmic":[8],"Reticulum":[9],"(ER)":[10],"mammalian":[12],"cells":[13],"exhibit":[14],"similarities":[15],"to":[16,53,55,95,135,168],"industrial":[17],"manufacturing":[18,93,161],"processes,":[19],"that":[21,79,99],"they":[22],"are":[23],"complex":[24,171],"systems":[25,34],"regulated":[26],"by":[27],"control":[28,33,144],"mechanisms.":[29],"Recently,":[30],"two":[31],"such":[32],"have":[35],"been":[36],"identified:":[37],"Unfolded":[39],"Protein":[40],"Response":[41],"(UPR)":[42],"AutoRegulation":[44],"ER":[46,52,107,158],"eXport":[47],"(AREX),":[48],"which":[49],"allow":[50],"adapt":[54],"fluctuations":[56],"stress.":[58],"However,":[59],"challenges":[61],"modeling":[63],"their":[64],"activities":[65],"arise":[66],"from":[67],"lack":[69],"data":[71],"complexity":[74],"signaling":[77],"pathways":[78],"activate":[80],"them.":[81],"In":[82],"this":[83],"study,":[84],"we":[85],"utilize":[86],"a":[87,97,160,165],"simulation":[88,150],"tool":[89],"commonly":[90],"employed":[91],"plants":[94],"develop":[96],"model":[98],"replicates":[100],"protein":[102,139],"production":[103,140],"process":[104,141,162],"actions":[110],"UPR":[113],"AREX":[115],"mitigating":[117],"stress":[118],"conditions.":[119],"Our":[120],"simulations":[121],"provide":[122,164],"insights":[123],"into":[124],"behavior":[126],"cell":[129],"represent":[131],"first":[133],"attempt":[134],"integrate":[136],"entire":[138],"activity":[145],"ER.":[148,175],"results":[151],"demonstrate":[152],"potential":[154],"regarding":[156],"as":[159],"novel":[166],"approach":[167],"understanding":[169],"regulation":[172]},"counts_by_year":[],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2025-10-10T00:00:00"}