{"id":"https://openalex.org/W2121896919","doi":"https://doi.org/10.1109/coase.2005.1506736","title":"Biopsy preparation for flow analysis using microfabricated disaggregation blades","display_name":"Biopsy preparation for flow analysis using microfabricated disaggregation blades","publication_year":2005,"publication_date":"2005-09-12","ids":{"openalex":"https://openalex.org/W2121896919","doi":"https://doi.org/10.1109/coase.2005.1506736","mag":"2121896919"},"language":"en","primary_location":{"id":"doi:10.1109/coase.2005.1506736","is_oa":false,"landing_page_url":"https://doi.org/10.1109/coase.2005.1506736","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE International Conference on Automation Science and Engineering, 2005.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113214997","display_name":"A.K. Miller","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A.K. Miller","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA","[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058610776","display_name":"M.L. Stanton","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.L. Stanton","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA","[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"[Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA]","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046153450","display_name":"Carissa A. Sanchez","orcid":"https://orcid.org/0000-0003-3861-1432"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.A. Sanchez","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA","Fred Hutchinson Cancer Research Center"],"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052243918","display_name":"Xiaohong Li","orcid":"https://orcid.org/0000-0003-4438-2664"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohong Li","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA","Fred Hutchinson Cancer Research Center"],"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046204284","display_name":"Sarah C. McQuaide","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.C. McQuaide","raw_affiliation_strings":["Department of Electrical Engineering, University of Washington, Seattle, WA","University of Washington"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025406097","display_name":"Brian J. Reid","orcid":"https://orcid.org/0000-0002-5352-1067"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.J. Reid","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113654966","display_name":"D.R. Meldrum","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.R. Meldrum","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110220043","display_name":"Tom Paulson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T.G. Paulson","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071323218","display_name":"Mark R. Holl","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.R. Holl","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5113214997"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18117347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.5752487778663635},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"Flow cytometry","score":0.5747290849685669},{"id":"https://openalex.org/keywords/biopsy","display_name":"Biopsy","score":0.4972565472126007},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4711177349090576},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4625045657157898},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4541073441505432},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4365934133529663},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4042871594429016},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.36597323417663574},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.36391353607177734},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.24255219101905823},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.13246500492095947},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10989394783973694},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10572642087936401},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.09616661071777344},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.08445653319358826},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07226055860519409}],"concepts":[{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5752487778663635},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5747290849685669},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4972565472126007},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4711177349090576},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4625045657157898},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4541073441505432},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4365934133529663},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4042871594429016},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36597323417663574},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.36391353607177734},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24255219101905823},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13246500492095947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10989394783973694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10572642087936401},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09616661071777344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.08445653319358826},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07226055860519409},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/coase.2005.1506736","is_oa":false,"landing_page_url":"https://doi.org/10.1109/coase.2005.1506736","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE International Conference on Automation Science and Engineering, 2005.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.4099999964237213}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1154178244","https://openalex.org/W1613109732","https://openalex.org/W1694820831","https://openalex.org/W1974148205","https://openalex.org/W2027783342","https://openalex.org/W2062011416","https://openalex.org/W2079455219","https://openalex.org/W2395709922","https://openalex.org/W2409737816","https://openalex.org/W2415856308"],"related_works":["https://openalex.org/W4211107619","https://openalex.org/W2161433272","https://openalex.org/W2894139091","https://openalex.org/W1637909","https://openalex.org/W2923650536","https://openalex.org/W1983780159","https://openalex.org/W659245948","https://openalex.org/W2094643072","https://openalex.org/W2087957833","https://openalex.org/W4206210906"],"abstract_inverted_index":{"An":[0],"epithelial":[1],"tissue":[2,96],"biopsy":[3,54],"processor":[4,25],"that":[5],"produces":[6],"stained":[7],"cell":[8,20],"nuclei":[9,21,79],"as":[10],"its":[11],"output":[12],"using":[13,66,83],"microfabricated":[14,93],"disaggregation":[15,55,74,100],"structures":[16],"is":[17],"presented.":[18,116],"Stained":[19],"produced":[22],"by":[23,59],"the":[24,37,42,48,53,73,87],"can":[26],"be":[27],"used":[28],"for":[29,111],"a":[30,60],"variety":[31],"of":[32,39,44,72,78,86],"diagnostic":[33],"tests":[34],"to":[35],"assess":[36],"presence":[38],"cancer":[40,46],"or":[41],"risk":[43],"developing":[45],"in":[47],"future.":[49],"To":[50],"better":[51],"understand":[52],"process,":[56],"biopsies":[57],"prepared":[58],"highly":[61],"skilled":[62],"technician":[63],"were":[64,81],"examined":[65],"fluorescence":[67],"microscopy":[68,101],"at":[69],"various":[70],"stages":[71],"process.":[75],"Quantitative":[76],"analysis":[77],"preparations":[80],"performed":[82],"flow":[84,106],"cytometry":[85,107],"end":[88],"product.":[89],"General":[90],"device":[91,113],"architecture,":[92],"glass":[94],"blade":[95],"mincing":[97],"structures,":[98],"manual":[99],"evaluation":[102],"results,":[103,108],"DNA":[104],"content":[105],"and":[109],"plans":[110],"further":[112],"development":[114],"are":[115]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}