{"id":"https://openalex.org/W2803566546","doi":"https://doi.org/10.1109/ciss.2018.8362246","title":"An efficient nonnegative matrix factorization model for finding cancer associated genes by integrating data from genome, transcriptome and interactome","display_name":"An efficient nonnegative matrix factorization model for finding cancer associated genes by integrating data from genome, transcriptome and interactome","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W2803566546","doi":"https://doi.org/10.1109/ciss.2018.8362246","mag":"2803566546"},"language":"en","primary_location":{"id":"doi:10.1109/ciss.2018.8362246","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ciss.2018.8362246","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 52nd Annual Conference on Information Sciences and Systems (CISS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006085047","display_name":"Jianing Xi","orcid":null},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianing Xi","raw_affiliation_strings":["School of Information Science and Technology, University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359729","display_name":"Ao Li","orcid":"https://orcid.org/0000-0001-9910-8967"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ao Li","raw_affiliation_strings":["School of Information Science and Technology, University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376902","display_name":"Minghui Wang","orcid":"https://orcid.org/0000-0002-5788-894X"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Wang","raw_affiliation_strings":["School of Information Science and Technology, University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126520041"],"apc_list":null,"apc_paid":null,"fwci":0.1856,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52885297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"6","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.7487895488739014},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6096678376197815},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6022847890853882},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5900683999061584},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5601659417152405},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4164489805698395},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4005982279777527},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3165830075740814},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.0804513692855835}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.7487895488739014},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6096678376197815},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6022847890853882},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5900683999061584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5601659417152405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4164489805698395},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4005982279777527},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3165830075740814},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0804513692855835}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/ciss.2018.8362246","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ciss.2018.8362246","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 52nd Annual Conference on Information Sciences and Systems (CISS)","raw_type":"proceedings-article"},{"id":"mag:3038559334","is_oa":false,"landing_page_url":"https://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=201802229712527525","pdf_url":null,"source":{"id":"https://openalex.org/S4306512817","display_name":"IEEE Conference Proceedings","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"IEEE Conference Proceedings","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1848939527","https://openalex.org/W1902027874","https://openalex.org/W1965856472","https://openalex.org/W1989795110","https://openalex.org/W1998519606","https://openalex.org/W2005129098","https://openalex.org/W2009720434","https://openalex.org/W2013988526","https://openalex.org/W2044433401","https://openalex.org/W2057545775","https://openalex.org/W2079849392","https://openalex.org/W2095319945","https://openalex.org/W2096283457","https://openalex.org/W2102140136","https://openalex.org/W2108119513","https://openalex.org/W2114843025","https://openalex.org/W2117513900","https://openalex.org/W2121906867","https://openalex.org/W2122863289","https://openalex.org/W2134471382","https://openalex.org/W2134508297","https://openalex.org/W2143017330","https://openalex.org/W2149082178","https://openalex.org/W2156718197","https://openalex.org/W2161112598","https://openalex.org/W2168103112","https://openalex.org/W2197241765","https://openalex.org/W2243002711","https://openalex.org/W2248435844","https://openalex.org/W2265227069","https://openalex.org/W2329659234","https://openalex.org/W2442835468","https://openalex.org/W2608749340","https://openalex.org/W2950984467","https://openalex.org/W4230962320","https://openalex.org/W6651297040","https://openalex.org/W6682755970"],"related_works":["https://openalex.org/W4292634579","https://openalex.org/W2022326234","https://openalex.org/W1531941329","https://openalex.org/W4388694323","https://openalex.org/W2987420353","https://openalex.org/W1491897707","https://openalex.org/W2056125010","https://openalex.org/W3005984791","https://openalex.org/W2169777166","https://openalex.org/W2007507741"],"abstract_inverted_index":{"The":[0],"recent":[1,41],"development":[2],"of":[3,11,38,69,138],"sequencing":[4],"technology":[5],"has":[6],"offered":[7],"us":[8],"the":[9,67,132,136],"opportunity":[10],"regarding":[12],"cancer":[13,21,27,57,71,94,127,142],"genome":[14,48],"as":[15],"a":[16],"biological":[17],"system":[18],"and":[19,49,105,120],"finding":[20,70],"associated":[22,28,58,72,95],"genes":[23,29],"computationally.":[24],"Since":[25],"some":[26],"may":[30],"be":[31],"omitted":[32],"when":[33],"using":[34],"only":[35],"mutation":[36,45],"frequencies":[37],"genes,":[39,73,96],"many":[40],"studies":[42],"use":[43],"both":[44],"data":[46],"from":[47,53,102],"gene":[50],"interaction":[51],"network":[52],"interactome":[54,106],"to":[55,79,92],"detect":[56],"genes.":[59,143],"However,":[60],"transcriptome":[61,104],"information":[62,101],"is":[63,75],"not":[64],"exploited":[65],"in":[66],"task":[68],"which":[74,97],"also":[76],"highly":[77],"related":[78],"cancer.":[80],"In":[81],"this":[82],"article,":[83],"we":[84,112],"introduce":[85],"an":[86],"nonnegative":[87],"matrix":[88],"factorization":[89],"based":[90],"model":[91],"find":[93],"can":[98],"efficiently":[99],"integrate":[100],"genome,":[103],"via":[107],"graph":[108],"Laplacian":[109],"regularization.":[110],"When":[111],"compare":[113],"our":[114,129],"method":[115,130],"with":[116],"two":[117,139],"existing":[118,133],"methods":[119,123,134],"apply":[121],"these":[122],"on":[124],"three":[125],"independent":[126],"datasets,":[128],"outperforms":[131],"for":[135],"evaluation":[137],"well-curated":[140],"known":[141]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}