{"id":"https://openalex.org/W2128032315","doi":"https://doi.org/10.1109/ciss.2009.5054835","title":"Ab initio exon definition using an information theory-based approach","display_name":"Ab initio exon definition using an information theory-based approach","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2128032315","doi":"https://doi.org/10.1109/ciss.2009.5054835","mag":"2128032315"},"language":"en","primary_location":{"id":"doi:10.1109/ciss.2009.5054835","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ciss.2009.5054835","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 43rd Annual Conference on Information Sciences and Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010680275","display_name":"Peter K. Rogan","orcid":"https://orcid.org/0000-0003-2070-5254"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Peter K. Rogan","raw_affiliation_strings":["Canada Research Chair in Genome Bioinformatics, University of Western Ontario, Canada","The University of Western Ontario USA"],"affiliations":[{"raw_affiliation_string":"Canada Research Chair in Genome Bioinformatics, University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario USA","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010680275"],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.14930995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"847","last_page":"852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/splice","display_name":"splice","score":0.863531231880188},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.7757788896560669},{"id":"https://openalex.org/keywords/bipartite-graph","display_name":"Bipartite graph","score":0.7079071998596191},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6059466004371643},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.5898845791816711},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5201531052589417},{"id":"https://openalex.org/keywords/ab-initio","display_name":"Ab initio","score":0.5108992457389832},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.452484667301178},{"id":"https://openalex.org/keywords/information-theory","display_name":"Information theory","score":0.44671934843063354},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.41343969106674194},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39904433488845825},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38095369935035706},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3672275245189667},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3183218836784363},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23109731078147888},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20986127853393555},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.1393933892250061},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10562515258789062},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.07995453476905823}],"concepts":[{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.863531231880188},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7757788896560669},{"id":"https://openalex.org/C197657726","wikidata":"https://www.wikidata.org/wiki/Q174733","display_name":"Bipartite graph","level":3,"score":0.7079071998596191},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6059466004371643},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5898845791816711},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5201531052589417},{"id":"https://openalex.org/C2781442258","wikidata":"https://www.wikidata.org/wiki/Q46310","display_name":"Ab initio","level":2,"score":0.5108992457389832},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.452484667301178},{"id":"https://openalex.org/C52622258","wikidata":"https://www.wikidata.org/wiki/Q131222","display_name":"Information theory","level":2,"score":0.44671934843063354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41343969106674194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39904433488845825},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38095369935035706},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3672275245189667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3183218836784363},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23109731078147888},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20986127853393555},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1393933892250061},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10562515258789062},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.07995453476905823},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ciss.2009.5054835","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ciss.2009.5054835","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 43rd Annual Conference on Information Sciences and Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W92004496","https://openalex.org/W1590648220","https://openalex.org/W1700314221","https://openalex.org/W1733966412","https://openalex.org/W1980961407","https://openalex.org/W1985738984","https://openalex.org/W1995875735","https://openalex.org/W1997182337","https://openalex.org/W2001730018","https://openalex.org/W2022169621","https://openalex.org/W2024588724","https://openalex.org/W2027699344","https://openalex.org/W2034691490","https://openalex.org/W2037825961","https://openalex.org/W2041998806","https://openalex.org/W2047944486","https://openalex.org/W2062888745","https://openalex.org/W2063318299","https://openalex.org/W2074703985","https://openalex.org/W2080667183","https://openalex.org/W2091607609","https://openalex.org/W2100179968","https://openalex.org/W2103647453","https://openalex.org/W2104434844","https://openalex.org/W2115804583","https://openalex.org/W2133143001","https://openalex.org/W2134201576","https://openalex.org/W2144885757","https://openalex.org/W2160053034","https://openalex.org/W2172188023","https://openalex.org/W4210430020"],"related_works":["https://openalex.org/W2068174058","https://openalex.org/W2130439870","https://openalex.org/W2151954452","https://openalex.org/W178291922","https://openalex.org/W2000278701","https://openalex.org/W2013066109","https://openalex.org/W2166782903","https://openalex.org/W1943031701","https://openalex.org/W3129862691","https://openalex.org/W1993348797"],"abstract_inverted_index":{"Transcribed":[0],"exons":[1],"in":[2,28],"genes":[3],"are":[4],"joined":[5],"together":[6],"at":[7],"donor":[8],"and":[9,14,56],"acceptor":[10],"splice":[11,30,46],"sites":[12,31],"precisely":[13],"efficiently":[15],"to":[16],"generate":[17],"mRNAs":[18,55],"capable":[19],"of":[20,44,54,77,87,94],"being":[21],"translated":[22],"into":[23],"proteins.":[24],"The":[25],"sequence":[26],"variability":[27],"individual":[29,45],"can":[32,62],"be":[33,63],"modeled":[34],"using":[35,65],"Shannon":[36],"information":[37,68],"theory.":[38],"In":[39],"the":[40,42,52,85,91],"laboratory,":[41],"degree":[43],"site":[47],"use":[48],"is":[49,72],"inferred":[50],"from":[51],"structures":[53,61],"their":[57],"relative":[58],"abundance.":[59],"These":[60],"predicted":[64],"a":[66],"bipartite":[67],"theory":[69],"framework":[70],"that":[71],"guided":[73],"by":[74],"current":[75],"knowledge":[76],"biological":[78],"mechanisms":[79],"for":[80,90],"exon":[81],"recognition.":[82],"We":[83],"present":[84],"results":[86],"this":[88],"analysis":[89],"complete":[92],"dataset":[93],"all":[95],"expressed":[96],"human":[97],"exons.":[98]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}