{"id":"https://openalex.org/W4410492698","doi":"https://doi.org/10.1109/cicc63670.2025.10983591","title":"A 0.7pA<sub>rms</sub> Electrochemical Readout IC for Continuous Monitoring of Antibody Biologics in Upstream Biomanufacturing","display_name":"A 0.7pA<sub>rms</sub> Electrochemical Readout IC for Continuous Monitoring of Antibody Biologics in Upstream Biomanufacturing","publication_year":2025,"publication_date":"2025-04-13","ids":{"openalex":"https://openalex.org/W4410492698","doi":"https://doi.org/10.1109/cicc63670.2025.10983591"},"language":"en","primary_location":{"id":"doi:10.1109/cicc63670.2025.10983591","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cicc63670.2025.10983591","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE Custom Integrated Circuits Conference (CICC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066376577","display_name":"Hung-Yu Hou","orcid":null},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung-Yu Hou","raw_affiliation_strings":["University of California,Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819853","display_name":"Ya-Chen Tsai","orcid":"https://orcid.org/0000-0001-7087-9741"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ya-Chen Tsai","raw_affiliation_strings":["University of California,Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085010941","display_name":"Wei Cho Foo","orcid":"https://orcid.org/0009-0001-2209-4728"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Foo","raw_affiliation_strings":["University of California,Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111013516","display_name":"Yan-Ting Hsiao","orcid":null},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan-Ting Hsiao","raw_affiliation_strings":["University of California,Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057902584","display_name":"Jun\u2010Chau Chien","orcid":"https://orcid.org/0000-0002-4197-8297"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun-Chau Chien","raw_affiliation_strings":["University of California,Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Berkeley","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4905,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61885034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9415000081062317,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9397000074386597,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomanufacturing","display_name":"Biomanufacturing","score":0.9394790530204773},{"id":"https://openalex.org/keywords/upstream","display_name":"Upstream (networking)","score":0.7081140279769897},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38215744495391846},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.11102774739265442},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.05835503339767456}],"concepts":[{"id":"https://openalex.org/C2775893736","wikidata":"https://www.wikidata.org/wiki/Q25324110","display_name":"Biomanufacturing","level":2,"score":0.9394790530204773},{"id":"https://openalex.org/C191172861","wikidata":"https://www.wikidata.org/wiki/Q7899321","display_name":"Upstream (networking)","level":2,"score":0.7081140279769897},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38215744495391846},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.11102774739265442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05835503339767456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cicc63670.2025.10983591","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cicc63670.2025.10983591","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE Custom Integrated Circuits Conference (CICC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G887633299","display_name":null,"funder_award_id":"2406340","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2889388596","https://openalex.org/W2964511835","https://openalex.org/W3033443422","https://openalex.org/W3048198911","https://openalex.org/W3081027044","https://openalex.org/W3091399767","https://openalex.org/W3093850252","https://openalex.org/W3112125306","https://openalex.org/W3152761281","https://openalex.org/W3193456703","https://openalex.org/W4210944729","https://openalex.org/W4231817520","https://openalex.org/W4360605375","https://openalex.org/W4366829684","https://openalex.org/W4385210237","https://openalex.org/W4393949869"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4294877544","https://openalex.org/W2490890447","https://openalex.org/W1548847100","https://openalex.org/W3124031114","https://openalex.org/W4283782326","https://openalex.org/W4295442981","https://openalex.org/W4311759274"],"abstract_inverted_index":{"Biologics":[0],"are":[1,9,41,112,223],"antibodies":[2,72],"produced":[3,42,201],"by":[4,43,49,73],"genetically":[5],"engineered":[6,44],"cells":[7,37,45,74],"and":[8,19,53,61,107,125,158,183,192,197,219,225],"widely":[10],"used":[11],"in":[12,24,46,122,203],"therapeutic":[13],"applications.":[14],"Examples":[15],"include":[16],"pembrolizumab":[17],"(Keytruda)":[18],"atezolizumab":[20],"(Tecentriq),":[21],"both":[22],"employed":[23],"cancer":[25],"immunotherapy":[26],"as":[27,98,217],"checkpoint":[28],"inhibitors":[29],"to":[30,63,78,85,135],"restore":[31],"T-cell":[32],"immune":[33],"responses":[34],"against":[35],"tumor":[36],"[1]\u2013[2].":[38],"These":[39,208],"biologics":[40,202],"bioreactors,":[47],"followed":[48],"extraction,":[50],"filtration,":[51],"purification,":[52],"separation,":[54],"before":[55],"being":[56],"packaged":[57],"into":[58],"drug":[59],"vials":[60],"shipped":[62],"hospitals":[64],"for":[65,91,155,228],"patient":[66],"treatment.":[67],"The":[68],"production":[69],"of":[70,174,199],"monoclonal":[71],"is":[75],"highly":[76],"sensitive":[77],"the":[79,123,136,165,195,200,206],"bioreactor":[80],"environment,":[81],"making":[82],"it":[83],"essential":[84],"integrate":[86],"process":[87,230],"analytical":[88],"technologies":[89],"(PAT)":[90],"closed-loop,":[92],"real-time":[93,204,229],"adjustments":[94],"[3]\u2013[4].":[95],"Parameters":[96],"such":[97,216],"pH,":[99,178],"ion":[100],"concentrations,":[101],"dissolved":[102],"oxygen,":[103],"carbon":[104],"dioxide,":[105],"pressure,":[106],"cell":[108],"density,":[109],"among":[110],"others,":[111],"routinely":[113],"monitored":[114],"through":[115],"in-line":[116],"(using":[117],"sensor":[118],"probes":[119],"immersed":[120],"directly":[121,191],"bioreactor)":[124],"on-line":[126],"(utilizing":[127],"a":[128],"bypass":[129],"channel":[130],"that":[131],"circulates":[132],"medium":[133],"back":[134],"tank)":[137],"approaches":[138],"with":[139,169],"discrete":[140],"sensors":[141],"[5]":[142],"(Fig.":[143],"1).":[144],"Recent":[145],"trends":[146],"have":[147],"focused":[148],"on":[149,213],"leveraging":[150],"integrated":[151],"circuit":[152],"(IC)":[153],"solutions":[154],"system":[156],"miniaturization":[157],"enhanced":[159],"functionality.":[160],"For":[161],"instance,":[162],"[6]":[163],"demonstrates":[164],"first":[166],"single":[167],"IC":[168],"multi-channel":[170],"capability,":[171],"enabling":[172],"monitoring":[173],"O<inf":[175],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[176],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>,":[177],"oxidation-reduction":[179],"potential":[180],"(ORP),":[181],"temperature,":[182],"glucose":[184],"levels.":[185],"However,":[186],"no":[187],"current":[188],"technology":[189],"can":[190],"continuously":[193],"quantify":[194],"concentration":[196],"quality":[198],"within":[205],"bioreactor.":[207],"critical":[209],"measurements":[210],"still":[211],"rely":[212],"off-line":[214],"methods":[215],"immunoassays":[218],"mass":[220],"spectrometry,":[221],"which":[222],"time-consuming":[224],"not":[226],"suitable":[227],"control.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}