{"id":"https://openalex.org/W2289863312","doi":"https://doi.org/10.1109/cic.2015.7411105","title":"Effects of amiodarone on ventricular excitation associated with the KCNJ2-linked short QT syndrome: Insights from a modelling study","display_name":"Effects of amiodarone on ventricular excitation associated with the KCNJ2-linked short QT syndrome: Insights from a modelling study","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2289863312","doi":"https://doi.org/10.1109/cic.2015.7411105","mag":"2289863312"},"language":"en","primary_location":{"id":"doi:10.1109/cic.2015.7411105","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411105","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074181962","display_name":"Cunjin Luo","orcid":"https://orcid.org/0000-0003-3946-1093"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cunjin Luo","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049558861","display_name":"Kuanquan Wang","orcid":"https://orcid.org/0000-0003-1347-3491"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kuanquan Wang","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101858661","display_name":"Ming Yuan","orcid":"https://orcid.org/0000-0001-9064-9740"},"institutions":[{"id":"https://openalex.org/I4210163738","display_name":"China Astronaut Research and Training Center","ror":"https://ror.org/001ycj259","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Yuan","raw_affiliation_strings":["State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China"],"affiliations":[{"raw_affiliation_string":"State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China","institution_ids":["https://openalex.org/I4210163738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026665","display_name":"Zhili Li","orcid":"https://orcid.org/0000-0001-9237-6176"},"institutions":[{"id":"https://openalex.org/I4210163738","display_name":"China Astronaut Research and Training Center","ror":"https://ror.org/001ycj259","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210163738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhili Li","raw_affiliation_strings":["State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China"],"affiliations":[{"raw_affiliation_string":"State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China","institution_ids":["https://openalex.org/I4210163738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016483201","display_name":"Qingjie Wang","orcid":"https://orcid.org/0000-0002-7944-8128"},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingjie Wang","raw_affiliation_strings":["Department of Cardiology, Zhongda Hospital of Southeast University, Nanjing, China"],"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhongda Hospital of Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I4210105806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107919406","display_name":"Yongfeng Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongfeng Yuan","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043556359","display_name":"Qince Li","orcid":"https://orcid.org/0000-0003-3447-7352"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qince Li","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043271142","display_name":"Henggui Zhang","orcid":"https://orcid.org/0000-0002-0863-5807"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Henggui Zhang","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","School of Physics and Astronomy, University of Manchester, Manchester, UK"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Physics and Astronomy, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5074181962"],"corresponding_institution_ids":["https://openalex.org/I204983213"],"apc_list":null,"apc_paid":null,"fwci":0.2483,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66017566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1093","last_page":"1096"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amiodarone","display_name":"Amiodarone","score":0.965484619140625},{"id":"https://openalex.org/keywords/short-qt-syndrome","display_name":"Short QT syndrome","score":0.8352727890014648},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6862339377403259},{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.5819758176803589},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.544544517993927},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5435038805007935},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.5307536125183105},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"Sudden cardiac death","score":0.4502449035644531},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"Long QT syndrome","score":0.3856416940689087},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.10887467861175537}],"concepts":[{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.965484619140625},{"id":"https://openalex.org/C2779578097","wikidata":"https://www.wikidata.org/wiki/Q1484058","display_name":"Short QT syndrome","level":4,"score":0.8352727890014648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6862339377403259},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.5819758176803589},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.544544517993927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5435038805007935},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.5307536125183105},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.4502449035644531},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.3856416940689087},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.10887467861175537}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cic.2015.7411105","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411105","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1518752784","https://openalex.org/W1524713415","https://openalex.org/W1965633790","https://openalex.org/W1967867484","https://openalex.org/W2045548568","https://openalex.org/W2077203000","https://openalex.org/W2107211009","https://openalex.org/W2114296544","https://openalex.org/W2116194046","https://openalex.org/W2154876398","https://openalex.org/W2160851716","https://openalex.org/W2161424604","https://openalex.org/W2163071496","https://openalex.org/W6630907010","https://openalex.org/W6677479921"],"related_works":["https://openalex.org/W2289863312","https://openalex.org/W2033888008","https://openalex.org/W2940115921","https://openalex.org/W2442419682","https://openalex.org/W4255881869","https://openalex.org/W133528620","https://openalex.org/W3106754853","https://openalex.org/W2129393568","https://openalex.org/W2643139323","https://openalex.org/W4280524955"],"abstract_inverted_index":{"Short":[0],"QT":[1,69],"syndrome":[2],"(SQTS)":[3],"is":[4],"associated":[5],"with":[6],"ventricular":[7,37,83],"arrhythmias":[8],"that":[9,88],"may":[10],"lead":[11],"to":[12,56,110],"cardiac":[13,63],"sudden":[14],"death.":[15],"However,":[16],"effective":[17],"pharmacological":[18,154],"treatment":[19,176],"for":[20,32,120,175],"SQTS":[21],"remains":[22],"unclear.":[23],"Amiodarone":[24],"has":[25],"emerged":[26],"as":[27],"the":[28,58,66,90,95,112,153,159,171],"leading":[29],"antiarrhythmic":[30],"therapy":[31],"termination":[33],"and":[34,48,85,117,130,132,139,147,181],"prevention":[35],"of":[36,44,52,60,65,72,99,128,136,156,161,173,177],"arrhythmia":[38],"in":[39,77,94,144],"different":[40],"clinical":[41],"settings":[42],"because":[43],"its":[45],"proven":[46],"efficacy":[47],"safety.":[49],"The":[50],"aim":[51],"this":[53],"study":[54,166],"was":[55],"investigate":[57],"effects":[59,114,155],"amiodarone":[61,100,157,174],"on":[62,115,158],"excitation":[64],"KCNJ2-linked":[67],"short":[68],"syndrome.":[70],"Effects":[71],"Kir2.1":[73],"D172N":[74,182],"mutation-induced":[75],"changes":[76],"IK1":[78],"were":[79,101,142,163],"incorporated":[80],"into":[81,170],"human":[82],"cell":[84],"tissue":[86,151],"models":[87],"considered":[89],"intrinsic":[91],"electrical":[92],"heterogeneity":[93],"left":[96],"ventricle.":[97],"Actions":[98],"simulated":[102,143],"by":[103],"implementing":[104],"a":[105],"simple":[106],"block":[107,119],"pore":[108],"theory":[109],"simulate":[111],"drug's":[113],"ICaL":[116,131],"IKr":[118,129],"several":[121],"doses.":[122],"In":[123,150],"cellular":[124],"simulations,":[125,152],"current":[126],"traces":[127],"action":[133],"potential":[134],"duration":[135],"ENDO,":[137],"M,":[138],"EPI":[140],"cells":[141],"control,":[145],"mutant,":[146],"amiodarone-in-action":[148],"conditions.":[149,183],"characteristics":[160],"ECG":[162],"examined.":[164],"This":[165],"provides":[167],"new":[168],"insights":[169],"pharmacokinetics":[172],"SQT3":[178],"under":[179],"WT-D172N":[180]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}