{"id":"https://openalex.org/W2271921673","doi":"https://doi.org/10.1109/cic.2015.7411104","title":"Model-based analysis of the effects of thioridazine enantiomers on the rabbit papillary action potential","display_name":"Model-based analysis of the effects of thioridazine enantiomers on the rabbit papillary action potential","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2271921673","doi":"https://doi.org/10.1109/cic.2015.7411104","mag":"2271921673"},"language":"en","primary_location":{"id":"doi:10.1109/cic.2015.7411104","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.cinc.org/archives/2015/pdf/1089.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078616322","display_name":"Ask Schou Jensen","orcid":null},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ask S Jensen","raw_affiliation_strings":["Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011976479","display_name":"Cristian Pablo Pennisi","orcid":"https://orcid.org/0000-0002-7716-1182"},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Cristian P Pennisi","raw_affiliation_strings":["Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044900404","display_name":"Cristian Sevcencu","orcid":"https://orcid.org/0000-0002-1240-3400"},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Cristian Sevcencu","raw_affiliation_strings":["Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045150424","display_name":"J\u00f8rn B. Christensen","orcid":"https://orcid.org/0000-0002-7641-8302"},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jorn B Christensen","raw_affiliation_strings":["Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107639873","display_name":"Jette E. Kristiansen","orcid":"https://orcid.org/0000-0002-8630-9249"},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jette E Kristiansen","raw_affiliation_strings":["Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080976736","display_name":"Johannes J. Struijk","orcid":"https://orcid.org/0000-0002-8713-1913"},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Johannes J Struijk","raw_affiliation_strings":["Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I891191580"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13239437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1089","last_page":"1092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thioridazine","display_name":"Thioridazine","score":0.8280363082885742},{"id":"https://openalex.org/keywords/enantiomer","display_name":"Enantiomer","score":0.423868328332901},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3621477782726288},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3447725772857666},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2580447196960449},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21469897031784058}],"concepts":[{"id":"https://openalex.org/C2780688371","wikidata":"https://www.wikidata.org/wiki/Q58375","display_name":"Thioridazine","level":3,"score":0.8280363082885742},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.423868328332901},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3621477782726288},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3447725772857666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2580447196960449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21469897031784058},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cic.2015.7411104","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:publications/eb6d4027-8d23-453d-9498-4e2b83bbc09d","is_oa":true,"landing_page_url":"https://vbn.aau.dk/da/publications/eb6d4027-8d23-453d-9498-4e2b83bbc09d","pdf_url":"http://www.cinc.org/archives/2015/pdf/1089.pdf","source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jensen, A S, Pennisi, C P, Sevcencu, C, Christensen, J B, Kristiansen, J E & Struijk, J J 2015, 'Model-based analysis of the effects of thioridazine enantiomers on the rabbit papillary action potential', Computing in Cardiology, vol. 42, pp. 1089-1092. https://doi.org/10.1109/CIC.2015.7411104","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:publications/eb6d4027-8d23-453d-9498-4e2b83bbc09d","is_oa":true,"landing_page_url":"https://vbn.aau.dk/da/publications/eb6d4027-8d23-453d-9498-4e2b83bbc09d","pdf_url":"http://www.cinc.org/archives/2015/pdf/1089.pdf","source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jensen, A S, Pennisi, C P, Sevcencu, C, Christensen, J B, Kristiansen, J E & Struijk, J J 2015, 'Model-based analysis of the effects of thioridazine enantiomers on the rabbit papillary action potential', Computing in Cardiology, vol. 42, pp. 1089-1092. https://doi.org/10.1109/CIC.2015.7411104","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2271921673.pdf","grobid_xml":"https://content.openalex.org/works/W2271921673.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1963888391","https://openalex.org/W1982140992","https://openalex.org/W2037927518","https://openalex.org/W2127928128","https://openalex.org/W2245892730","https://openalex.org/W2264507302","https://openalex.org/W2321061449"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W4391375266","https://openalex.org/W2016228987","https://openalex.org/W2076937345","https://openalex.org/W2113973316","https://openalex.org/W2134083385","https://openalex.org/W2087184269","https://openalex.org/W2067275115","https://openalex.org/W2082601447","https://openalex.org/W166510078"],"abstract_inverted_index":{"Aims:":[0],"We":[1],"investigated":[2],"mechanisms":[3],"underlying":[4],"the":[5,8,12,26,78,93,135,140,164,170,175],"effects":[6,61,96,172],"of":[7,25,39,77,84,92,104,143],"thioridazine":[9],"enantiomers":[10],"on":[11],"rabbit":[13,27],"papillary":[14,47],"action":[15,29],"potential":[16,30],"duration":[17],"(AP,":[18],"APD).":[19],"Methods:":[20],"An":[21],"adapted":[22],"computational":[23],"model":[24],"ventricular":[28,46],"was":[31],"used":[32],"to":[33,150,156,180],"carry":[34],"out":[35],"a":[36,69,88],"model-based":[37],"analysis":[38],"transmembrane":[40],"AP":[41],"recordings":[42],"from":[43,49],"isolated":[44],"right":[45],"muscles":[48],"21":[50],"rabbits":[51],"in":[52,87,174],"four":[53],"groups:":[54],"control,":[55],"(-)-thioridazine,":[56],"(+)-thioridazine,":[57],"and":[58,68,119,139],"racemate.":[59,165],"Drug":[60],"were":[62,73,146],"determined":[63],"using":[64],"an":[65],"inverse":[66],"method":[67],"forward":[70],"method.":[71],"Effects":[72],"modeled":[74],"by":[75],"inhibition":[76,83,145],"IKrand":[79,85],"ICaLcurrents.":[80],"Results:":[81],"Simultaneous":[82],"ICaLresulted":[86],"more":[89],"accurate":[90],"description":[91],"observed":[94,136,173],"drug":[95],"than":[97,160],"could":[98],"IKrinhibition":[99,105,132,159],"alone.":[100],"The":[101],"following":[102],"values":[103],"at":[106],"10":[107],"mg":[108],"L-1were":[109],"determined.":[110],"Forward":[111],"method:":[112,124],"Racemate":[113],"=":[114,117,121,126,129],"45%,":[115],"(-)-thioridazine":[116,155],"0%,":[118],"(+)-thioridazine":[120,128],"85%.":[122],"Inverse":[123],"(-)thioridazine":[125],"35%,":[127],"80%.":[130],"Conclusion:":[131],"accurately":[133],"described":[134],"APD":[137],"prolongation,":[138],"identified":[141],"levels":[142],"IKr":[144,181],"plausible":[147],"when":[148],"compared":[149],"literature.":[151],"Both":[152],"methods":[153],"found":[154],"cause":[157],"less":[158],"(+":[161],")-thioridazine":[162],"or":[163],"These":[166],"results":[167],"indicate":[168],"that":[169],"prolonging":[171],"experiment":[176],"may":[177],"be":[178],"related":[179],"inhibition.":[182]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}