{"id":"https://openalex.org/W2289337326","doi":"https://doi.org/10.1109/cic.2015.7411045","title":"In silico investigation of short QT syndrome-linked potassium channel mutations on electro-mechanical function of human atrial cells","display_name":"In silico investigation of short QT syndrome-linked potassium channel mutations on electro-mechanical function of human atrial cells","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2289337326","doi":"https://doi.org/10.1109/cic.2015.7411045","mag":"2289337326"},"language":"en","primary_location":{"id":"doi:10.1109/cic.2015.7411045","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411045","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036632412","display_name":"David J. Whittaker","orcid":"https://orcid.org/0000-0002-2757-5491"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dominic G Whittaker","raw_affiliation_strings":["3.08 Schuster Laboratory, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3.08 Schuster Laboratory, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064034861","display_name":"Michael A. Colman","orcid":"https://orcid.org/0000-0003-2817-8508"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael A Colman","raw_affiliation_strings":["University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002106325","display_name":"Haibo Ni","orcid":"https://orcid.org/0000-0003-0083-4286"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haibo Ni","raw_affiliation_strings":["University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037737415","display_name":"Jules C. Hancox","orcid":"https://orcid.org/0000-0002-2055-6482"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jules C Hancox","raw_affiliation_strings":["University of Bristol, Bristol, UK","University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043271142","display_name":"Henggui Zhang","orcid":"https://orcid.org/0000-0002-0863-5807"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henggui Zhang","raw_affiliation_strings":["University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6533,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.74932772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"853","last_page":"856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herg","display_name":"hERG","score":0.9646245241165161},{"id":"https://openalex.org/keywords/short-qt-syndrome","display_name":"Short QT syndrome","score":0.9315478205680847},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.64752596616745},{"id":"https://openalex.org/keywords/torsades-de-pointes","display_name":"Torsades de pointes","score":0.5499892830848694},{"id":"https://openalex.org/keywords/patch-clamp","display_name":"Patch clamp","score":0.5489202737808228},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5441776514053345},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.49308010935783386},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.45045238733291626},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"Long QT syndrome","score":0.4465394914150238},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42354440689086914},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.35808253288269043},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.35218894481658936},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.3477395474910736},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3219817280769348},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.3143131732940674},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.3140098452568054},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1489693820476532}],"concepts":[{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.9646245241165161},{"id":"https://openalex.org/C2779578097","wikidata":"https://www.wikidata.org/wiki/Q1484058","display_name":"Short QT syndrome","level":4,"score":0.9315478205680847},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.64752596616745},{"id":"https://openalex.org/C2780486423","wikidata":"https://www.wikidata.org/wiki/Q1625433","display_name":"Torsades de pointes","level":3,"score":0.5499892830848694},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.5489202737808228},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5441776514053345},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.49308010935783386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45045238733291626},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.4465394914150238},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42354440689086914},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35808253288269043},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35218894481658936},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3477395474910736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3219817280769348},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.3143131732940674},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.3140098452568054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1489693820476532}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cic.2015.7411045","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411045","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1482350832","https://openalex.org/W1522772747","https://openalex.org/W1809798419","https://openalex.org/W1965633790","https://openalex.org/W1966872591","https://openalex.org/W1969060286","https://openalex.org/W2019201408","https://openalex.org/W2053958437","https://openalex.org/W2058240154","https://openalex.org/W2060625193","https://openalex.org/W2092718904","https://openalex.org/W2096261252","https://openalex.org/W2104749146","https://openalex.org/W2120263248","https://openalex.org/W2124148610","https://openalex.org/W2127748321","https://openalex.org/W2159561758","https://openalex.org/W2399104811","https://openalex.org/W2485799441","https://openalex.org/W6631071478","https://openalex.org/W6712669487"],"related_works":["https://openalex.org/W2060105258","https://openalex.org/W1971881653","https://openalex.org/W1997071795","https://openalex.org/W2028521745","https://openalex.org/W2180517827","https://openalex.org/W2094120230","https://openalex.org/W2409143881","https://openalex.org/W2039784878","https://openalex.org/W2940115921","https://openalex.org/W2388475879"],"abstract_inverted_index":{"Short":[0],"QT":[1],"syndrome":[2],"(SQTS)":[3],"patients":[4],"are":[5,80],"prone":[6],"to":[7,55,123],"atrial":[8,18,43,48,125],"arrhythmias.":[9],"However,":[10],"the":[11,27,38,56,65,75,83,136,154],"link":[12],"between":[13],"SQTS":[14],"gene":[15],"mutations":[16,36,120,155],"and":[17,67,73,85,97,112,118],"pro-arrhythmia":[19],"is":[20],"not":[21],"well":[22],"understood.":[23],"This":[24],"study":[25],"investigated":[26],"functional":[28],"impact":[29],"of":[30,41,64,78,135,153],"two":[31],"SQTS-related":[32],"gain-of-function":[33],"potassium":[34,130],"channel":[35],"on":[37],"electro-mechanical":[39],"activities":[40],"human":[42,47],"cells.":[44],"A":[45],"contemporary":[46],"action":[49,140],"potential":[50,141],"(AP)":[51],"model":[52],"was":[53,164],"coupled":[54],"Rice":[57],"et":[58],"al.":[59],"mechanics":[60],"model.":[61],"Markov":[62,102],"formulations":[63],"rapid":[66],"slow":[68],"delayed":[69],"rectifier":[70],"currents,":[71],"iKr":[72],"iKs,":[74],"a":[76],"subunits":[77],"which":[79,138,163],"encoded":[81],"by":[82,127],"hERG":[84],"KCNQJ":[86],"genes,":[87],"respectively,":[88],"were":[89,104,121,170],"implemented":[90],"in":[91,157],"wild":[92],"type":[93],"(WT),":[94],"N588K-hERG":[95,117],"(SQTJ),":[96],"V307L-KCNQJ":[98,119],"(SQT2)":[99],"conditions.":[100],"The":[101,116],"models":[103],"validated":[105],"against":[106],"experimental":[107],"data":[108],"through":[109],"simulated":[110],"voltage":[111],"AP":[113],"clamp":[114],"experiments.":[115],"found":[122],"accelerate":[124],"repolarisation":[126,145],"increasing":[128],"outward":[129],"currents":[131],"during":[132],"phase":[133],"3":[134],"AP,":[137],"reduced":[139],"duration":[142],"at":[143],"90%":[144],"(APD":[146],"<sub":[147],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[148],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">90</sub>":[149],").":[150],"Secondary":[151],"effects":[152],"resulted":[156],"impaired":[158],"contractile":[159],"force,":[160],"an":[161],"effect":[162],"lessened":[165],"when":[166],"stretch-activated":[167],"channels":[168],"(SACs)":[169],"incorporated.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}