{"id":"https://openalex.org/W2292702719","doi":"https://doi.org/10.1109/cic.2015.7411043","title":"Circadian modulation on T-wave alternans activity in chronic heart failure patients","display_name":"Circadian modulation on T-wave alternans activity in chronic heart failure patients","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2292702719","doi":"https://doi.org/10.1109/cic.2015.7411043","mag":"2292702719"},"language":"en","primary_location":{"id":"doi:10.1109/cic.2015.7411043","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411043","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Figures_-_voltage_membrane_traces_for_1D_Purkinje-ventricle_model/4520006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084954923","display_name":"Alba Mart\u00edn-Yebra","orcid":"https://orcid.org/0000-0003-0226-4950"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]},{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES","IT"],"is_corresponding":true,"raw_author_name":"Alba Martin-Yebra","raw_affiliation_strings":["BSICoS Group, Universidad de Zaragoza, Zaragoza, Spain","DEIB, Politecnico di Milano Piazza Leonardo da Vinci, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"BSICoS Group, Universidad de Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"DEIB, Politecnico di Milano Piazza Leonardo da Vinci, Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015515154","display_name":"Enrico G. Caiani","orcid":"https://orcid.org/0000-0002-1770-6486"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico G Caiani","raw_affiliation_strings":["Dipartimento di Elettronica, Politecnico di Milano, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084527753","display_name":"Pablo Laguna","orcid":"https://orcid.org/0000-0003-3434-9254"},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Laguna","raw_affiliation_strings":["BSICoS Group, Universidad de Zaragoza, Zaragoza, Spain","CIBER en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"BSICoS Group, Universidad de Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"CIBER en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088797297","display_name":"Violeta Monasterio","orcid":"https://orcid.org/0000-0001-5343-5671"},"institutions":[{"id":"https://openalex.org/I4210121238","display_name":"Universidad San Jorge","ror":"https://ror.org/01wbg2c90","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210121238"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Violeta Monasterio","raw_affiliation_strings":["Universidad San Jorge, Villanueva de G\u00e1llego, Spain"],"affiliations":[{"raw_affiliation_string":"Universidad San Jorge, Villanueva de G\u00e1llego, Spain","institution_ids":["https://openalex.org/I4210121238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055142189","display_name":"Juan Pablo Mart\u00ed\u00adnez","orcid":"https://orcid.org/0000-0002-7503-3339"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Pablo Martinez","raw_affiliation_strings":["BSICoS Group, Universidad de Zaragoza, Zaragoza, Spain","CIBER en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"BSICoS Group, Universidad de Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"CIBER en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain","institution_ids":["https://openalex.org/I4210105141"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084954923"],"corresponding_institution_ids":["https://openalex.org/I255234318","https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":0.2126,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62798591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":null,"first_page":"845","last_page":"848"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.8417874574661255},{"id":"https://openalex.org/keywords/t-wave-alternans","display_name":"T wave alternans","score":0.7687298059463501},{"id":"https://openalex.org/keywords/quartile","display_name":"Quartile","score":0.7046241760253906},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6903095841407776},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.68128502368927},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6541865468025208},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"Hazard ratio","score":0.6496124863624573},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.5812202095985413},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"Sudden cardiac death","score":0.5799671411514282},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.46002545952796936},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.45519647002220154},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.4274910092353821},{"id":"https://openalex.org/keywords/confidence-interval","display_name":"Confidence interval","score":0.14987334609031677},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.12099677324295044}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8417874574661255},{"id":"https://openalex.org/C2777325121","wikidata":"https://www.wikidata.org/wiki/Q3613169","display_name":"T wave alternans","level":3,"score":0.7687298059463501},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.7046241760253906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6903095841407776},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.68128502368927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6541865468025208},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6496124863624573},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5812202095985413},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.5799671411514282},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.46002545952796936},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45519647002220154},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.4274910092353821},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.14987334609031677},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.12099677324295044},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/cic.2015.7411043","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7411043","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},{"id":"pmh:oai:figshare.com:article/4520006","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Figures_-_voltage_membrane_traces_for_1D_Purkinje-ventricle_model/4520006","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:re.public.polimi.it:11311/985699","is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/985699","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:zaguan.unizar.es:63104","is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/63104","pdf_url":null,"source":{"id":"https://openalex.org/S4306402461","display_name":"Zaguan (Universidad de Zaragoza)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"doi:10.6084/m9.figshare.4520006.v4","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.4520006.v4","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/4520006","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Figures_-_voltage_membrane_traces_for_1D_Purkinje-ventricle_model/4520006","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W121250741","https://openalex.org/W1975840526","https://openalex.org/W1988280325","https://openalex.org/W1996033332","https://openalex.org/W2049131779","https://openalex.org/W2074852127","https://openalex.org/W2093671121","https://openalex.org/W2116950334","https://openalex.org/W2149506897","https://openalex.org/W2152502128"],"related_works":["https://openalex.org/W2187428238","https://openalex.org/W2025372916","https://openalex.org/W2041363330","https://openalex.org/W2075177274","https://openalex.org/W2181510192","https://openalex.org/W1878698680","https://openalex.org/W1490541616","https://openalex.org/W2970223320","https://openalex.org/W2054088930","https://openalex.org/W2147335401"],"abstract_inverted_index":{"Average":[0],"TWA":[1,29,38,51,80],"activity":[2],"has":[3],"been":[4],"shown":[5],"to":[6,55,124],"be":[7,188],"an":[8,101],"independent":[9,102],"predictor":[10],"of":[11,25,50,73,147,152,159],"sudden":[12],"cardiac":[13],"death":[14],"(SCD)":[15],"in":[16,40,84,128,145],"chronic":[17],"heart":[18,131],"failure":[19],"(CHF)":[20],"patients.":[21],"However,":[22,134],"the":[23,47,56,78,107,115,125,129,156],"influence":[24],"circadian":[26,37,57,185],"rhythms":[27],"on":[28,155],"remains":[30],"understudied.":[31],"In":[32,183],"this":[33],"work,":[34],"we":[35],"assessed":[36],"changes":[39],"a":[41,90,135],"CHF":[42,65],"population":[43],"and":[44,143,169],"evaluated":[45],"whether":[46],"prognostic":[48],"value":[49],"indices":[52,163],"is":[53,122],"sensitive":[54],"pattern.":[58],"Holter":[59],"ECG":[60],"recordings":[61],"from":[62],"626":[63],"consecutive":[64,86],"patients":[66,153],"(52":[67],"SCD)":[68],"were":[69],"analyzed.":[70],"The":[71],"index":[72],"average":[74,79],"alternans":[75],"(IAA),":[76],"quantifying":[77],"level,":[81],"was":[82,96,139],"measured":[83],"4":[85],"6-hour":[87],"intervals":[88],"using":[89],"multilead":[91],"fully-automated":[92],"method.":[93],"Survival":[94],"analysis":[95],"performed":[97],"considering":[98],"SCD":[99,174,191],"as":[100],"endpoint.":[103],"IAA":[104,142,160,162],"changed":[105],"along":[106],"day,":[108],"with":[109],"statistically":[110],"significant":[111],"lower":[112],"values":[113],"during":[114,118],"night":[116],"than":[117],"daytime.":[119],"This":[120],"pattern":[121],"similar":[123],"one":[126],"observed":[127],"mean":[130],"rate":[132],"(HR).":[133],"low":[136],"correlation":[137],"(r=.18)":[138],"found":[140],"between":[141,165],"HR":[144],"windows":[146],"128":[148],"beats.":[149],"After":[150],"dichotomization":[151],"based":[154],"third":[157],"quartile":[158],"indices,":[161],"computed":[164],"hours":[166],"06-12":[167],"(IAA06-12)":[168],"18-24":[170],"(IAA18-24)":[171],"successfully":[172],"predicted":[173],"(Hazard":[175],"Ratio,":[176],"HaR:2.34(1.33-4.13)per":[177],"\u03bcV,":[178,181],"andHaR:1.87(1.04-3.36)":[179],"per":[180],"respectively).":[182],"conclusion,":[184],"variation":[186],"should":[187],"considered":[189],"for":[190],"risk":[192],"prediction.":[193]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}