{"id":"https://openalex.org/W2292581946","doi":"https://doi.org/10.1109/cic.2015.7408685","title":"Quantification of the effects of electrical remodeling due to hypertrophic cardiomyopathy on human ventricular electromechanical activity and energetics","display_name":"Quantification of the effects of electrical remodeling due to hypertrophic cardiomyopathy on human ventricular electromechanical activity and energetics","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2292581946","doi":"https://doi.org/10.1109/cic.2015.7408685","mag":"2292581946"},"language":"en","primary_location":{"id":"doi:10.1109/cic.2015.7408685","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7408685","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070275364","display_name":"Gareth M. Jones","orcid":"https://orcid.org/0000-0002-3627-9440"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth M Jones","raw_affiliation_strings":["Biological Physics Group, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Physics Group, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064034861","display_name":"Michael A. Colman","orcid":"https://orcid.org/0000-0003-2817-8508"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael A Colman","raw_affiliation_strings":["Biological Physics Group, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Physics Group, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043271142","display_name":"Henggui Zhang","orcid":"https://orcid.org/0000-0002-0863-5807"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henggui Zhang","raw_affiliation_strings":["Biological Physics Group, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Physics Group, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17114089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"457","last_page":"460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"Phosphocreatine","score":0.6074907779693604},{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"Hypertrophic cardiomyopathy","score":0.4912678599357605},{"id":"https://openalex.org/keywords/inotrope","display_name":"Inotrope","score":0.4536750018596649},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"Oxidative phosphorylation","score":0.4313713312149048},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4266696274280548},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"Cardiomyopathy","score":0.42483022809028625},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35160690546035767},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.25532644987106323},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20431771874427795},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18795326352119446},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"Energy metabolism","score":0.1546764373779297}],"concepts":[{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.6074907779693604},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.4912678599357605},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.4536750018596649},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4313713312149048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4266696274280548},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.42483022809028625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35160690546035767},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.25532644987106323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20431771874427795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18795326352119446},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.1546764373779297}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cic.2015.7408685","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7408685","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1894886257","https://openalex.org/W1964430604","https://openalex.org/W2011399604","https://openalex.org/W2023793544","https://openalex.org/W2025666521","https://openalex.org/W2038237757","https://openalex.org/W2039866873","https://openalex.org/W2115765852","https://openalex.org/W2122341467"],"related_works":["https://openalex.org/W2436864505","https://openalex.org/W2416306383","https://openalex.org/W2000502510","https://openalex.org/W1500269813","https://openalex.org/W2410005511","https://openalex.org/W2434646466","https://openalex.org/W2151760453","https://openalex.org/W2330037927","https://openalex.org/W2014272583","https://openalex.org/W2041636020"],"abstract_inverted_index":{"Hypertrophic":[0],"cardiomyopathy":[1,131],"caused":[2],"by":[3,33,165],"mutations":[4],"in":[5,99,112,157],"genes":[6],"coding":[7],"for":[8,59],"sarcomeric":[9],"proteins":[10],"leads":[11,88],"to":[12,29,89,133,169],"electrical":[13,38,47,86],"remodeling,":[14,39],"oxidative":[15,40],"stress":[16,41],"and":[17,42,62,77,102,109,140,161],"energetic":[18,43,162],"impairment.":[19],"This":[20],"study":[21],"combines":[22],"recently":[23],"published":[24],"models":[25],"of":[26,74,93,114,146],"each":[27],"component":[28],"investigate":[30],"the":[31,35,147,158],"mechanisms":[32],"which":[34],"hypertrophic":[36,130],"cardiomyopathy-induced":[37],"malfunction":[44],"affect":[45],"cardiac":[46],"activities.":[48],"A":[49,64,123],"current":[50],"electrophysiological":[51],"model":[52,68,73],"was":[53,69,83,127,155,167],"updated":[54],"with":[55,129],"recent":[56],"experimental":[57],"data":[58],"both":[60,100],"control":[61],"disease.":[63],"metabolite":[65],"sensitive":[66],"myofilament":[67],"incorporated":[70],"alongside":[71],"a":[72,90],"mitochondrial":[75,150],"energetics":[76],"reactive":[78,151],"oxygen":[79,152],"species":[80,153],"production.":[81],"It":[82],"shown":[84],"that":[85],"remodeling":[87],"substantial":[91],"prolongation":[92],"action":[94],"potential":[95],"duration,":[96],"an":[97],"increase":[98,111],"systolic":[101],"diastolic":[103],"Ca":[104,116,135,141],"<sup":[105,117,136,142],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[106,118,137,143],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2+</sup>":[107,119,138,144],"levels":[108,113],"concomitant":[110],"active":[115],"/calmodulin":[120],"kinase":[121],"II.":[122],"positive":[124],"inotropic":[125],"effect":[126],"seen":[128],"due":[132],"increased":[134],"concentration":[139],"sensitivity":[145],"myofilament.":[148],"Greater":[149],"production":[154],"observed":[156],"diseased":[159],"cell":[160],"buffering":[163],"capacity":[164],"phosphocreatine":[166],"found":[168],"be":[170],"diminished.":[171]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}