{"id":"https://openalex.org/W2292811558","doi":"https://doi.org/10.1109/cic.2015.7408651","title":"Mathematical modeling of the role of cooperativity between contractile and regulatory proteins in the mechano-calcium feedbacks in myocardium","display_name":"Mathematical modeling of the role of cooperativity between contractile and regulatory proteins in the mechano-calcium feedbacks in myocardium","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2292811558","doi":"https://doi.org/10.1109/cic.2015.7408651","mag":"2292811558"},"language":"en","primary_location":{"id":"doi:10.1109/cic.2015.7408651","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7408651","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076419292","display_name":"E. V. Shikhaleva","orcid":null},"institutions":[{"id":"https://openalex.org/I4210104979","display_name":"Institute of Immunology and Physiology","ror":"https://ror.org/01qt3dj82","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104979","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E Shikhaleva","raw_affiliation_strings":["Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I4210104979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047952598","display_name":"Tatiana Sulman","orcid":null},"institutions":[{"id":"https://openalex.org/I130823665","display_name":"Ural Federal University","ror":"https://ror.org/00hs7dr46","country_code":"RU","type":"education","lineage":["https://openalex.org/I130823665"]},{"id":"https://openalex.org/I4210104979","display_name":"Institute of Immunology and Physiology","ror":"https://ror.org/01qt3dj82","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104979","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T Sulman","raw_affiliation_strings":["Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","Ural Federal University, Ekaterinburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I4210104979"]},{"raw_affiliation_string":"Ural Federal University, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I130823665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000482189","display_name":"Arsenii Dokuchaev","orcid":"https://orcid.org/0000-0002-2396-1678"},"institutions":[{"id":"https://openalex.org/I130823665","display_name":"Ural Federal University","ror":"https://ror.org/00hs7dr46","country_code":"RU","type":"education","lineage":["https://openalex.org/I130823665"]},{"id":"https://openalex.org/I4210104979","display_name":"Institute of Immunology and Physiology","ror":"https://ror.org/01qt3dj82","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104979","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A Dokuchaev","raw_affiliation_strings":["Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","Ural Federal University, Ekaterinburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I4210104979"]},{"raw_affiliation_string":"Ural Federal University, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I130823665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081142687","display_name":"\u041b. \u0412. \u041d\u0438\u043a\u0438\u0442\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0002-7174-2357"},"institutions":[{"id":"https://openalex.org/I4210104979","display_name":"Institute of Immunology and Physiology","ror":"https://ror.org/01qt3dj82","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104979","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Larisa V Nikitina","raw_affiliation_strings":["Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I4210104979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041410766","display_name":"Leonid B. Katsnelson","orcid":"https://orcid.org/0000-0001-9553-9110"},"institutions":[{"id":"https://openalex.org/I130823665","display_name":"Ural Federal University","ror":"https://ror.org/00hs7dr46","country_code":"RU","type":"education","lineage":["https://openalex.org/I130823665"]},{"id":"https://openalex.org/I4210104979","display_name":"Institute of Immunology and Physiology","ror":"https://ror.org/01qt3dj82","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104979","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Leonid B Katsnelson","raw_affiliation_strings":["Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","Ural Federal University, Ekaterinburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I4210104979"]},{"raw_affiliation_string":"Ural Federal University, Ekaterinburg, Russia","institution_ids":["https://openalex.org/I130823665"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":null,"first_page":"321","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.815416157245636},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.7703875303268433},{"id":"https://openalex.org/keywords/contraction","display_name":"Contraction (grammar)","score":0.5563402771949768},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4528806805610657},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42049479484558105},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.41704633831977844},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19577980041503906},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17598223686218262},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.1206265389919281}],"concepts":[{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.815416157245636},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7703875303268433},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5563402771949768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4528806805610657},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42049479484558105},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41704633831977844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19577980041503906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17598223686218262},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1206265389919281},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cic.2015.7408651","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cic.2015.7408651","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1809467165","https://openalex.org/W1968621403","https://openalex.org/W1971202056","https://openalex.org/W2015642658","https://openalex.org/W2021138337","https://openalex.org/W2023063315","https://openalex.org/W2033320718","https://openalex.org/W2035949471","https://openalex.org/W2062336211","https://openalex.org/W2064341415","https://openalex.org/W2076238227","https://openalex.org/W2097949661","https://openalex.org/W2145659218","https://openalex.org/W2154965092"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W4391952536","https://openalex.org/W1985538928"],"abstract_inverted_index":{"There":[0],"is":[1,20,39],"a":[2],"complicated":[3],"interplay":[4],"between":[5],"different":[6],"factors":[7],"contributing":[8],"to":[9,24,41],"the":[10,14,31,37,42,52],"calcium":[11,54],"regulation":[12],"of":[13,44],"heart":[15],"muscle":[16],"contraction.":[17],"Mathematical":[18],"modeling":[19,38],"an":[21],"efficient":[22],"approach":[23],"analyze":[25],"this":[26,35],"compound":[27],"system":[28],"and":[29,48],"recognize":[30],"key":[32],"links.":[33],"In":[34],"work":[36],"applied":[40],"analysis":[43],"mechano-calcium":[45],"feedback":[46],"mechanisms":[47],"their":[49],"role":[50],"in":[51],"cardiomyocyte":[53],"activation.":[55]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}