{"id":"https://openalex.org/W4414647937","doi":"https://doi.org/10.1109/cibcb66090.2025.11177115","title":"Decoding Aging: Multi-Omics Insights into Oxidative Stress, Mitochondrial Dysfunction, and Cellular Senescence in Fibroblasts","display_name":"Decoding Aging: Multi-Omics Insights into Oxidative Stress, Mitochondrial Dysfunction, and Cellular Senescence in Fibroblasts","publication_year":2025,"publication_date":"2025-08-20","ids":{"openalex":"https://openalex.org/W4414647937","doi":"https://doi.org/10.1109/cibcb66090.2025.11177115"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb66090.2025.11177115","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb66090.2025.11177115","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020656667","display_name":"Rema Mandal","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143528","display_name":"Lexington City Schools","ror":"https://ror.org/043f52r95","country_code":"US","type":"education","lineage":["https://openalex.org/I4210143528"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rajarshi Mandal","raw_affiliation_strings":["Lexington High School,Boston,USA"],"affiliations":[{"raw_affiliation_string":"Lexington High School,Boston,USA","institution_ids":["https://openalex.org/I4210143528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100746429","display_name":"Ning Xie","orcid":"https://orcid.org/0000-0002-4628-2299"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Xie","raw_affiliation_strings":["Harvard Medical School,Biomedical Cybernetics Laboratory,Boston,USA"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School,Biomedical Cybernetics Laboratory,Boston,USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103190902","display_name":"Gil Alterovitz","orcid":"https://orcid.org/0000-0002-5952-9844"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gil Alterovitz","raw_affiliation_strings":["Harvard Medical School,Biomedical Cybernetics Laboratory,Boston,USA"],"affiliations":[{"raw_affiliation_string":"Harvard Medical School,Biomedical Cybernetics Laboratory,Boston,USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020656667"],"corresponding_institution_ids":["https://openalex.org/I4210143528"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24194224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8870000243186951,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8870000243186951,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.8317999839782715,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.824400007724762,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7960000038146973},{"id":"https://openalex.org/keywords/senescence","display_name":"Senescence","score":0.6678000092506409},{"id":"https://openalex.org/keywords/bioenergetics","display_name":"Bioenergetics","score":0.6263999938964844},{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.5777999758720398},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.5435000061988831},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.5044999718666077},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"Mitochondrial DNA","score":0.49480000138282776},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.4885999858379364},{"id":"https://openalex.org/keywords/fibroblast","display_name":"Fibroblast","score":0.4699999988079071},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"Cellular senescence","score":0.44749999046325684}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7960000038146973},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6678000092506409},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6496999859809875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6290000081062317},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.6263999938964844},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5777999758720398},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5435000061988831},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5044999718666077},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.49480000138282776},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4885999858379364},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4699999988079071},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.44749999046325684},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.44429999589920044},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.44290000200271606},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.42399999499320984},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.38830000162124634},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.36719998717308044},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3573000133037567},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.34869998693466187},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.32510000467300415},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3246999979019165},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.3192000091075897},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.30239999294281006},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2865000069141388},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.2791999876499176},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.2734000086784363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27230000495910645},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.27090001106262207},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2567000091075897},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb66090.2025.11177115","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb66090.2025.11177115","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1887061159","https://openalex.org/W1985904396","https://openalex.org/W1991696505","https://openalex.org/W1998137132","https://openalex.org/W2040802623","https://openalex.org/W2051614538","https://openalex.org/W2053308873","https://openalex.org/W2094457621","https://openalex.org/W2096058937","https://openalex.org/W2107439917","https://openalex.org/W2171705978","https://openalex.org/W2233660390","https://openalex.org/W2610923556","https://openalex.org/W2728708949","https://openalex.org/W2730173011","https://openalex.org/W2735466792","https://openalex.org/W2753346007","https://openalex.org/W2805709488","https://openalex.org/W2810959600","https://openalex.org/W2886094455","https://openalex.org/W2979330888","https://openalex.org/W3022561886","https://openalex.org/W3037923724","https://openalex.org/W3085526035","https://openalex.org/W3095368098","https://openalex.org/W3158011519","https://openalex.org/W4210377729","https://openalex.org/W4296773799","https://openalex.org/W4300980915","https://openalex.org/W4310938517","https://openalex.org/W4312094983"],"related_works":[],"abstract_inverted_index":{"This":[0,19],"research":[1,171],"investigates":[2],"the":[3,71,77,102],"complex":[4],"biochemical":[5],"mechanisms":[6],"underlying":[7],"aging":[8,81],"by":[9,91],"analyzing":[10,116],"primary":[11],"human":[12],"fibroblasts":[13,79],"using":[14],"a":[15],"longitudinal":[16],"multi-omics":[17],"dataset.":[18],"dataset":[20],"includes":[21],"cytology,":[22],"DNA":[23,150],"methylation":[24],"and":[25,29,56,74,97,120,133,155,167],"epigenetic":[26,165],"clocks,":[27,52],"bioenergetics,":[28],"cytokine":[30],"profiling.":[31],"Key":[32],"findings":[33],"indicate":[34],"that":[35,76],"mitochondrial":[36,106,163],"efficiency":[37],"declines":[38],"with":[39,61,84],"age,":[40],"while":[41],"glycolysis":[42],"becomes":[43],"more":[44],"prevalent":[45],"to":[46,127],"compensate":[47],"for":[48,176],"energy":[49],"demands.":[50],"Epigenetic":[51],"such":[53,130],"as":[54,131],"Hannum":[55],"PhenoAge,":[57],"showed":[58],"strong":[59],"correlations":[60],"biological":[62],"age":[63],"(\u03c1":[64],">":[65],"0.650,":[66],"p":[67],"<":[68],"1e-6),":[69],"validating":[70],"experimental":[72],"setup":[73],"confirming":[75],"cultured":[78],"were":[80,113,125],"appropriately.":[82],"Fibroblasts":[83],"SURF1":[85],"mutations":[86],"exhibited":[87],"accelerated":[88],"aging,":[89],"marked":[90],"bioenergetic":[92],"deficits,":[93],"increased":[94,149],"cell":[95],"volume,":[96],"reduced":[98,145],"proliferative":[99],"capacity,":[100],"underscoring":[101],"pivotal":[103],"role":[104],"of":[105,123],"dysfunction":[107],"in":[108],"cellular":[109,142,157],"senescence.":[110],"Novel":[111],"insights":[112],"gained":[114],"from":[115],"cytokines":[117],"like":[118],"IL-18":[119],"PCSK9,":[121],"some":[122],"which":[124],"linked":[126],"age-related":[128,177],"diseases":[129],"Alzheimer\u2019s":[132],"cardiovascular":[134],"disorders.":[135],"Experimental":[136],"treatments":[137],"revealed":[138],"distinct":[139],"effects":[140],"on":[141],"aging.":[143],"Dexamethasone":[144],"inflammation":[146],"but":[147],"also":[148],"methylation,":[151],"induced":[152],"metabolic":[153],"inefficiencies,":[154],"shortened":[156],"lifespan.":[158],"By":[159],"uncovering":[160],"connections":[161],"between":[162],"dysfunction,":[164],"biomarkers,":[166],"immune":[168],"dysregulation,":[169],"this":[170],"identifies":[172],"potential":[173],"therapeutic":[174],"targets":[175],"diseases.":[178]},"counts_by_year":[],"updated_date":"2026-03-07T16:01:11.037858","created_date":"2025-10-10T00:00:00"}
