{"id":"https://openalex.org/W4414647733","doi":"https://doi.org/10.1109/cibcb66090.2025.11177058","title":"Integrative Framework for Functional analysis of multiple Traditional Chinese Medicines based on transcriptome-driven systems biology and supervised learning strategy","display_name":"Integrative Framework for Functional analysis of multiple Traditional Chinese Medicines based on transcriptome-driven systems biology and supervised learning strategy","publication_year":2025,"publication_date":"2025-08-20","ids":{"openalex":"https://openalex.org/W4414647733","doi":"https://doi.org/10.1109/cibcb66090.2025.11177058"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb66090.2025.11177058","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb66090.2025.11177058","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101714041","display_name":"Yun Tang","orcid":"https://orcid.org/0000-0002-8807-5239"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Tang","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067453693","display_name":"Chia\u2010Ru Chung","orcid":"https://orcid.org/0000-0002-4548-7620"},"institutions":[{"id":"https://openalex.org/I22265921","display_name":"National Central University","ror":"https://ror.org/00944ve71","country_code":"TW","type":"education","lineage":["https://openalex.org/I22265921"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Ru Chung","raw_affiliation_strings":["National Central University,Department of Computer Science and Information Engineering,Taoyuan,Taiwan R.O.C,320317"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Central University,Department of Computer Science and Information Engineering,Taoyuan,Taiwan R.O.C,320317","institution_ids":["https://openalex.org/I22265921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hsi-Yuan Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hsi-Yuan Huang","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088375595","display_name":"Yang-Chi-Dung Lin","orcid":"https://orcid.org/0000-0003-2436-4602"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang-Chi-Dung Lin","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033766175","display_name":"Hua\u2010Li Zuo","orcid":"https://orcid.org/0000-0002-0359-2481"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua-Li Zuo","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337862","display_name":"Jing Li","orcid":"https://orcid.org/0000-0003-4072-4102"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379665","display_name":"Liping Li","orcid":"https://orcid.org/0000-0002-2994-6583"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Li","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102754035","display_name":"Siyao Hu","orcid":"https://orcid.org/0000-0001-5646-2632"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyao Hu","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021200806","display_name":"Hsiao-Chin Hong","orcid":"https://orcid.org/0000-0001-5871-9067"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hsiao-Chin Hong","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455830","display_name":"Fei Wang","orcid":"https://orcid.org/0000-0002-4004-1021"},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jinrui Bai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinrui Bai","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111820971","display_name":"Hsien-Da Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hsien-Da Huang","raw_affiliation_strings":["The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Chinese University of Hong Kong,Warshel Institute for Computational Biology, School of Medicine,Shenzhen,P.R. China,518172","institution_ids":["https://openalex.org/I4210116924"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9334999918937683,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9334999918937683,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6018000245094299},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4893999993801117},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.4799000024795532},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.4724000096321106},{"id":"https://openalex.org/keywords/supervised-learning","display_name":"Supervised learning","score":0.4560999870300293},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4489000141620636},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4092999994754791},{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.40049999952316284},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.3549000024795532},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.35030001401901245}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6018000245094299},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5623000264167786},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4893999993801117},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.4799000024795532},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4724000096321106},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4620000123977661},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.4560999870300293},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45010000467300415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4489000141620636},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4447000026702881},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4092999994754791},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37880000472068787},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.3549000024795532},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.35030001401901245},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.34880000352859497},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.3154999911785126},{"id":"https://openalex.org/C58973888","wikidata":"https://www.wikidata.org/wiki/Q1041418","display_name":"Semi-supervised learning","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2962000072002411},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C55112680","wikidata":"https://www.wikidata.org/wiki/Q190549","display_name":"Functional analysis","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb66090.2025.11177058","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb66090.2025.11177058","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322170","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86"},{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2010457001","https://openalex.org/W2035618305","https://openalex.org/W2036897871","https://openalex.org/W2100980426","https://openalex.org/W2109628770","https://openalex.org/W2124679671","https://openalex.org/W2130410032","https://openalex.org/W2159675211","https://openalex.org/W2169456326","https://openalex.org/W2406526524","https://openalex.org/W2500727927","https://openalex.org/W2592811885","https://openalex.org/W2884403624","https://openalex.org/W2903808414","https://openalex.org/W2928431398","https://openalex.org/W3006653136","https://openalex.org/W3010497490","https://openalex.org/W3081345523","https://openalex.org/W3107527779","https://openalex.org/W3112917721","https://openalex.org/W3196681928","https://openalex.org/W4220729278","https://openalex.org/W4289550253","https://openalex.org/W4294216483","https://openalex.org/W4297200828","https://openalex.org/W4308364542","https://openalex.org/W4317042486"],"related_works":[],"abstract_inverted_index":{"Traditional":[0],"Chinese":[1],"Medicines":[2],"(TCMs)":[3],"contain":[4],"a":[5,28,38,184,194],"wide":[6],"variety":[7],"of":[8,101,179],"ingredients":[9],"and":[10,20,41,68,89,97,130,148,170],"are":[11,35],"rich":[12],"in":[13,30,37,181,188],"bioactive":[14],"chemical":[15],"sources.":[16],"However,":[17],"their":[18],"complex":[19],"unknown":[21],"effects":[22],"on":[23,154],"the":[24,158,174],"human":[25],"body":[26],"prove":[27],"challenge":[29],"TCM":[31,95,139,164],"research.":[32],"Multiple":[33],"genes":[34,77,100,112,123,191],"involved":[36],"biological":[39],"system":[40],"disease":[42],"progression;":[43],"therefore,":[44],"transcriptome-driven":[45],"systems":[46],"biology":[47],"approach":[48],"directs":[49],"our":[50],"attention":[51],"to":[52,93,109,137,166],"perturbed":[53,171],"pathways":[54],"or":[55],"enriched":[56],"gene":[57,61],"sets":[58],"from":[59],"whole":[60],"expression":[62,83,87],"profile,":[63],"allowing":[64],"more":[65],"explanatory":[66],"power":[67],"less":[69],"analytical":[70],"complexity":[71],"than":[72],"solely":[73],"considering":[74],"differentially":[75],"expressed":[76],"(DEGs).":[78],"This":[79],"framework":[80],"integrated":[81],"differential":[82],"analysis":[84,88],"(DEA),":[85],"pathway-based":[86],"supervised":[90,185],"learning":[91,105,186],"approaches":[92,106],"explore":[94],"functions":[96],"extract":[98,110],"signature":[99,111,122,167],"high":[102],"importance.":[103],"Supervised":[104],"were":[107,124,135],"employed":[108],"that":[113],"effectively":[114],"discriminate":[115],"between":[116],"four":[117],"TCMs":[118],"(92%":[119],"accuracy).":[120],"These":[121],"further":[125],"examined":[126],"through":[127],"database":[128],"annotations":[129],"literature":[131],"survey,":[132],"where":[133],"some":[134],"found":[136],"be":[138],"compound":[140],"targets,":[141],"such":[142],"as":[143],"fatty":[144],"acid":[145],"synthase":[146],"(FASN)":[147],"thioredoxin":[149],"reductase":[150],"1":[151],"(TXNRD1).":[152],"Based":[153],"network":[155,161],"pharmacology":[156],"concept,":[157],"proposed":[159],"TCM-compound-target-pathway":[160],"can":[162,192],"link":[163],"compounds":[165],"genes,":[168],"DEGs":[169],"pathways,":[172],"revealing":[173],"rationale":[175],"behind":[176],"TCM\u2019s":[177],"mechanism":[178],"action":[180],"treatment.":[182],"Integrating":[183],"strategy":[187],"identifying":[189],"TCM-associated":[190],"offer":[193],"new":[195],"perspective":[196],"for":[197],"discovering":[198],"potential":[199],"drug":[200],"targets.":[201]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}