{"id":"https://openalex.org/W4403210515","doi":"https://doi.org/10.1109/cibcb58642.2024.10702141","title":"ViPeC: Vision transformer-based approach for Peptide-protein interface Classification","display_name":"ViPeC: Vision transformer-based approach for Peptide-protein interface Classification","publication_year":2024,"publication_date":"2024-08-27","ids":{"openalex":"https://openalex.org/W4403210515","doi":"https://doi.org/10.1109/cibcb58642.2024.10702141"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb58642.2024.10702141","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb58642.2024.10702141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010805715","display_name":"Lucas Moraes dos Santos","orcid":"https://orcid.org/0000-0003-4214-1576"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Lucas Moraes Dos Santos","raw_affiliation_strings":["Federal University of Minas Gerais,Department of Computer Science,Belo Horizonte,MG,Brazil"],"affiliations":[{"raw_affiliation_string":"Federal University of Minas Gerais,Department of Computer Science,Belo Horizonte,MG,Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023320487","display_name":"Diego Mariano","orcid":"https://orcid.org/0000-0002-5899-2052"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Diego Mariano","raw_affiliation_strings":["Federal University of Minas Gerais,Department of Computer Science,Belo Horizonte,MG,Brazil"],"affiliations":[{"raw_affiliation_string":"Federal University of Minas Gerais,Department of Computer Science,Belo Horizonte,MG,Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069672238","display_name":"Raquel C. de Melo-Minardi","orcid":"https://orcid.org/0000-0001-5190-100X"},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raquel Cardoso de Melo Minardi","raw_affiliation_strings":["Federal University of Minas Gerais,Department of Computer Science,Belo Horizonte,MG,Brazil"],"affiliations":[{"raw_affiliation_string":"Federal University of Minas Gerais,Department of Computer Science,Belo Horizonte,MG,Brazil","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010805715"],"corresponding_institution_ids":["https://openalex.org/I110200422"],"apc_list":null,"apc_paid":null,"fwci":0.2501,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58728852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6627807021141052},{"id":"https://openalex.org/keywords/transformer","display_name":"Transformer","score":0.526315450668335},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4298827648162842},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.36524882912635803},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1689184010028839},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.13865026831626892}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6627807021141052},{"id":"https://openalex.org/C66322947","wikidata":"https://www.wikidata.org/wiki/Q11658","display_name":"Transformer","level":3,"score":0.526315450668335},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4298827648162842},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.36524882912635803},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1689184010028839},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.13865026831626892},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb58642.2024.10702141","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb58642.2024.10702141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2030636483","https://openalex.org/W2096679774","https://openalex.org/W2503135644","https://openalex.org/W2724823461","https://openalex.org/W2947234294","https://openalex.org/W3048900928","https://openalex.org/W3109831997","https://openalex.org/W3120712761","https://openalex.org/W3129322014","https://openalex.org/W3199607358","https://openalex.org/W3211024740","https://openalex.org/W3215525389","https://openalex.org/W4283166323","https://openalex.org/W4315641887","https://openalex.org/W4321108300","https://openalex.org/W4385075189","https://openalex.org/W4386363419","https://openalex.org/W4388067722","https://openalex.org/W6675704316","https://openalex.org/W6739901393","https://openalex.org/W6766978945"],"related_works":["https://openalex.org/W2058170566","https://openalex.org/W2772917594","https://openalex.org/W2755342338","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398","https://openalex.org/W2775347418"],"abstract_inverted_index":{"Peptides,":[0],"which":[1],"are":[2],"composed":[3],"of":[4,19,30,38,76,139,142,158,187,194],"short-chain":[5],"amino":[6],"acids,":[7],"have":[8,15,34],"high":[9],"flexibility":[10],"and":[11,14,74,105,125,146,155,165],"low":[12],"toxicity,":[13],"attracted":[16],"the":[17,27,36,50,54,66,72,121,137,140,143,185,192],"attention":[18],"industry":[20],"due":[21,48],"to":[22,49,108,198],"their":[23,61],"potential":[24,77],"role":[25],"in":[26,161,167,173,190],"rational":[28],"design":[29,75],"medicines.":[31],"Consequently,":[32],"they":[33,69],"become":[35],"focus":[37],"numerous":[39,55],"computational":[40],"studies,":[41,176],"mainly":[42],"leveraging":[43],"deep":[44],"learning":[45],"approaches.":[46],"However,":[47],"intricate":[51],"physicochemical":[52],"interactions,":[53],"interactions":[56,135],"that":[57],"peptides":[58,79],"perform":[59],"with":[60],"receptors,":[62],"as":[63,65],"well":[64],"diverse":[67],"conformations":[68],"can":[70],"adopt,":[71],"discovery":[73],"inhibitory":[78],"still":[80],"remains":[81],"a":[82,88,152],"challenge.":[83],"Here,":[84],"we":[85,117],"present":[86],"ViPeC,":[87],"vision":[89,106],"transformer-based":[90],"approach":[91,178,189],"for":[92],"peptide-protein":[93],"interface":[94],"classification.":[95],"Our":[96,149],"method":[97,150],"leverages":[98],"structural":[99],"signatures":[100],"constructed":[101],"using":[102],"contact":[103],"maps":[104],"transformers":[107],"classify":[109],"protein-peptide":[110,134,195],"interaction":[111],"interfaces.":[112],"To":[113],"evaluate":[114],"our":[115,177,188],"methodology,":[116],"collected":[118],"data":[119],"from":[120],"Propedia":[122],"peptide":[123,144],"database":[124],"conducted":[126],"two":[127],"case":[128,162,168,175],"studies.":[129,200],"These":[130,182],"studies":[131],"involved":[132],"classifying":[133],"on":[136],"basis":[138],"similarity":[141],"sequence":[145],"receptor":[147],"function.":[148],"achieved":[151],"precision,":[153],"recall":[154],"F1":[156],"score":[157],"approximately":[159],"99.0%":[160],"study":[163,169],"A":[164],"95.0%":[166],"B.":[170],"In":[171],"particular,":[172],"both":[174],"outperformed":[179],"its":[180],"competitors.":[181],"results":[183],"underscore":[184],"effectiveness":[186],"improving":[191],"classification":[193],"complexes":[196],"compared":[197],"previous":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-12-21T01:58:51.020947","created_date":"2025-10-10T00:00:00"}