{"id":"https://openalex.org/W4293519271","doi":"https://doi.org/10.1109/cibcb55180.2022.9863027","title":"Identification of the Prognostic Signatures for Isocitrate Dehydrogenase Mutant Glioma","display_name":"Identification of the Prognostic Signatures for Isocitrate Dehydrogenase Mutant Glioma","publication_year":2022,"publication_date":"2022-08-15","ids":{"openalex":"https://openalex.org/W4293519271","doi":"https://doi.org/10.1109/cibcb55180.2022.9863027"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb55180.2022.9863027","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb55180.2022.9863027","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057342710","display_name":"Yasin Mamatjan","orcid":"https://orcid.org/0000-0002-8807-2927"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I160262251","display_name":"Thompson Rivers University","ror":"https://ror.org/01v9wj339","country_code":"CA","type":"education","lineage":["https://openalex.org/I160262251"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Yasin Mamatjan","raw_affiliation_strings":["Rivers University,Faculty of Science, Thompson,BC,Canada","Princess Margaret Cancer Centre, Toronto, Canada","Faculty of Science, Thompson, Rivers University, BC, Canada"],"affiliations":[{"raw_affiliation_string":"Rivers University,Faculty of Science, Thompson,BC,Canada","institution_ids":["https://openalex.org/I160262251"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Faculty of Science, Thompson, Rivers University, BC, Canada","institution_ids":["https://openalex.org/I160262251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019043638","display_name":"Mathew Voisin","orcid":"https://orcid.org/0000-0002-1191-9579"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mathew Voisin","raw_affiliation_strings":["MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","institution_ids":["https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007013927","display_name":"Farshad Nassiri","orcid":"https://orcid.org/0000-0002-0797-3425"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Farshad Nassiri","raw_affiliation_strings":["MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","institution_ids":["https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068287655","display_name":"Mira Salih","orcid":"https://orcid.org/0000-0002-8093-6508"},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mira Salih","raw_affiliation_strings":["Boston Beth Israel Deaconess Medical Center,Boston,MA,USA","Boston Beth Israel Deaconess Medical Center, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Boston Beth Israel Deaconess Medical Center,Boston,MA,USA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Boston Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016682199","display_name":"F\u00e1bio Ynoe de Moraes","orcid":"https://orcid.org/0000-0003-3407-9215"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I4210096394","display_name":"Queens University","ror":"https://ror.org/00strmv13","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210096394"]}],"countries":["BD","CA"],"is_corresponding":false,"raw_author_name":"Fabio Y. Moraes","raw_affiliation_strings":["Department of Oncology Queens University,Kingston,ON,Canada","Department of Oncology Queens University, Kingston, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Oncology Queens University,Kingston,ON,Canada","institution_ids":["https://openalex.org/I4210096394"]},{"raw_affiliation_string":"Department of Oncology Queens University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031832951","display_name":"Severa Bunda","orcid":null},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Severa Bunda","raw_affiliation_strings":["MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","institution_ids":["https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027231098","display_name":"Risalet Tursun","orcid":null},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Risalet Tursun","raw_affiliation_strings":["Institute of Oncology Istanbul University,Istanbul,Turkey","Institute of Oncology Istanbul University, Istanbul, Turkey"],"affiliations":[{"raw_affiliation_string":"Institute of Oncology Istanbul University,Istanbul,Turkey","institution_ids":["https://openalex.org/I67581229"]},{"raw_affiliation_string":"Institute of Oncology Istanbul University, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052657395","display_name":"Andreas von Deimling","orcid":"https://orcid.org/0000-0002-5863-540X"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas von Deimling","raw_affiliation_strings":["Heidelberg University Hospital,Department of Neuropathology,Heidelberg,Germany","Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Heidelberg University Hospital,Department of Neuropathology,Heidelberg,Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063290790","display_name":"Kenneth Aldape","orcid":"https://orcid.org/0000-0001-5119-7550"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. Aldape","raw_affiliation_strings":["National Cancer Institute,Laboratory of Pathology,Bethesda,MD,USA","Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"National Cancer Institute,Laboratory of Pathology,Bethesda,MD,USA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072584423","display_name":"Gelareh Zadeh","orcid":"https://orcid.org/0000-0002-6637-4502"},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gelareh Zadeh","raw_affiliation_strings":["MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"MacFeeters-Hamilton Center for Neuro-Oncology Research,Princess Margaret Cancer Centre,Toronto,Canada","institution_ids":["https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, MacFeeters-Hamilton Center for Neuro-Oncology Research, Toronto, Canada","institution_ids":["https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5057342710"],"corresponding_institution_ids":["https://openalex.org/I160262251","https://openalex.org/I2802654988"],"apc_list":null,"apc_paid":null,"fwci":0.1525,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50784701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isocitrate-dehydrogenase","display_name":"Isocitrate dehydrogenase","score":0.8144339323043823},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6181946992874146},{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.6074751019477844},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5637525320053101},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.5547260642051697},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.5507881045341492},{"id":"https://openalex.org/keywords/subtyping","display_name":"Subtyping","score":0.4953388273715973},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4834083616733551},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.4641132950782776},{"id":"https://openalex.org/keywords/idh2","display_name":"IDH2","score":0.435153603553772},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3636184334754944},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.32871168851852417},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32689371705055237},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.3263137936592102},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.29812246561050415},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2908742427825928},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2466745674610138},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1526990532875061},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.0960114598274231}],"concepts":[{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.8144339323043823},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6181946992874146},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6074751019477844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5637525320053101},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.5547260642051697},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5507881045341492},{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.4953388273715973},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4834083616733551},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4641132950782776},{"id":"https://openalex.org/C2776059313","wikidata":"https://www.wikidata.org/wiki/Q21116031","display_name":"IDH2","level":5,"score":0.435153603553772},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3636184334754944},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32871168851852417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32689371705055237},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3263137936592102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29812246561050415},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2908742427825928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2466745674610138},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1526990532875061},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0960114598274231},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb55180.2022.9863027","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb55180.2022.9863027","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5699999928474426,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W228600387","https://openalex.org/W1988141621","https://openalex.org/W1993605227","https://openalex.org/W2001493754","https://openalex.org/W2036044314","https://openalex.org/W2040827479","https://openalex.org/W2096330673","https://openalex.org/W2101870168","https://openalex.org/W2105528101","https://openalex.org/W2106209651","https://openalex.org/W2126817554","https://openalex.org/W2138336030","https://openalex.org/W2141410747","https://openalex.org/W2144727376","https://openalex.org/W2263206910","https://openalex.org/W2366536035","https://openalex.org/W2618667624","https://openalex.org/W2759629762","https://openalex.org/W2796572741","https://openalex.org/W2951388646","https://openalex.org/W2956589719","https://openalex.org/W3010221055"],"related_works":["https://openalex.org/W2084945856","https://openalex.org/W2069303197","https://openalex.org/W4307264101","https://openalex.org/W2126817554","https://openalex.org/W2128680685","https://openalex.org/W4366704913","https://openalex.org/W1906458404","https://openalex.org/W1969013165","https://openalex.org/W2310653790","https://openalex.org/W1979801327"],"abstract_inverted_index":{"Diffuse":[0],"gliomas":[1,19,54,199],"can":[2],"be":[3],"divided":[4],"based":[5],"on":[6],"presence":[7],"or":[8],"absence":[9],"of":[10,24,50,64,179,182,191,197],"mutation":[11,96],"in":[12,52,60,194],"isocitrate":[13],"dehydrogenase":[14],"(IDH)":[15],"genes.":[16],"IDH-mutant":[17],"diffuse":[18,53,198],"represent":[20],"a":[21,47,180,210],"wide":[22],"range":[23],"clinical":[25,34],"outcome,":[26],"which":[27],"is":[28],"not":[29],"accounted":[30],"for":[31,75],"by":[32],"current":[33],"and":[35,45,95,146,177],"pathologic":[36],"parameters.":[37],"To":[38],"address":[39],"this,":[40],"we":[41],"aim":[42],"to":[43,55,98,200],"identify":[44,99,201],"characterize":[46],"predictive":[48],"signature":[49],"outcome":[51,167,196],"better":[56],"understand":[57],"this":[58],"heterogeneity":[59],"outcome.":[61,106],"A":[62],"total":[63],"310":[65],"IDH":[66],"mutant":[67],"glioma":[68,122],"samples":[69,81],"with":[70,79,170],"methylation":[71,162],"data":[72,97],"were":[73,136],"used":[74],"the":[76,121,161,189,195,207],"analysis":[77,108,118],"together":[78],"419":[80],"from":[82,109,115,144],"The":[83,133,157],"Cancer":[84,149],"Genome":[85],"Atlas":[86],"(TCGA),":[87],"utilizing":[88],"methylation,":[89],"mRNA,":[90],"copy":[91],"number":[92],"variation":[93],"(CNV)":[94],"unique":[100],"molecular":[101,203],"signatures":[102,114,135,163],"that":[103,119,128,160,164],"predict":[104,165],"patient":[105],"Methylation":[107],"our":[110],"test":[111],"cohort":[112,123],"identified":[113],"Cox":[116],"regression":[117],"split":[120],"into":[124],"two":[125,140],"prognostic":[126],"groups":[127],"strongly":[129],"predicted":[130],"survival":[131],"(p-value<0.0001).":[132],"CpG-based":[134],"reliably":[137],"validated":[138],"using":[139],"independent":[141],"validation":[142],"datasets":[143],"TCGA":[145],"DKFZ":[147],"(German":[148],"Research":[150],"Center)":[151],"cohorts":[152],"(both":[153],"p-values":[154],"<":[155],"0.0001).":[156],"results":[158,187],"show":[159],"poor":[166],"also":[168],"correlated":[169],"G-CIMP":[171],"low":[172],"status,":[173],"elevated":[174],"CNV":[175],"instability":[176],"hypermethylation":[178],"set":[181],"HOX":[183,192],"gene":[184],"probes.":[185],"These":[186],"demonstrate":[188],"importance":[190],"genes":[193],"relevant":[202],"subtyping":[204],"indistinguishable":[205],"under":[206],"microscope":[208],"within":[209],"histology.":[211]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}