{"id":"https://openalex.org/W3206599837","doi":"https://doi.org/10.1109/cibcb49929.2021.9562876","title":"Identification of Genes Associated with Alzheimer's Disease using Evolutionary Computation","display_name":"Identification of Genes Associated with Alzheimer's Disease using Evolutionary Computation","publication_year":2021,"publication_date":"2021-10-13","ids":{"openalex":"https://openalex.org/W3206599837","doi":"https://doi.org/10.1109/cibcb49929.2021.9562876","mag":"3206599837"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb49929.2021.9562876","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb49929.2021.9562876","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101970918","display_name":"Guangyao Chen","orcid":"https://orcid.org/0000-0002-6351-9083"},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Guangyao Chen","raw_affiliation_strings":["Dept. of Computer Science, Brock University, St. Catharines, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science, Brock University, St. Catharines, ON, Canada","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007479288","display_name":"James Sargant","orcid":null},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James Sargant","raw_affiliation_strings":["Dept. of Computer Science, Brock University, St. Catharines, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science, Brock University, St. Catharines, ON, Canada","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037172617","display_name":"Sheridan Houghten","orcid":"https://orcid.org/0000-0001-5164-7910"},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sheridan Houghten","raw_affiliation_strings":["Dept. of Computer Science, Brock University, St. Catharines, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science, Brock University, St. Catharines, ON, Canada","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067897113","display_name":"Tyler K. Collins","orcid":null},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tyler K. Collins","raw_affiliation_strings":["SHARCNET Brock University, St. Catharines, ON, Canada"],"affiliations":[{"raw_affiliation_string":"SHARCNET Brock University, St. Catharines, ON, Canada","institution_ids":["https://openalex.org/I186803428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101970918"],"corresponding_institution_ids":["https://openalex.org/I186803428"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0996711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.9495397806167603},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.711277961730957},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.5808232426643372},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.5755840539932251},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5220851302146912},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4801294505596161},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.46813830733299255},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4546220600605011},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4428028464317322},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4336532950401306},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.42521756887435913},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3910559415817261},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33440303802490234},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29581284523010254},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2750355899333954},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2535731792449951},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2006174623966217},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15180480480194092}],"concepts":[{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.9495397806167603},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.711277961730957},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.5808232426643372},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.5755840539932251},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5220851302146912},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4801294505596161},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46813830733299255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4546220600605011},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4428028464317322},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4336532950401306},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42521756887435913},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3910559415817261},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33440303802490234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29581284523010254},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2750355899333954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2535731792449951},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2006174623966217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15180480480194092},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb49929.2021.9562876","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb49929.2021.9562876","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1499476884","https://openalex.org/W1637627250","https://openalex.org/W1960602938","https://openalex.org/W1985213868","https://openalex.org/W2004403098","https://openalex.org/W2009018507","https://openalex.org/W2062533676","https://openalex.org/W2099970772","https://openalex.org/W2112513984","https://openalex.org/W2119412782","https://openalex.org/W2119943416","https://openalex.org/W2132022337","https://openalex.org/W2136936410","https://openalex.org/W2137531873","https://openalex.org/W2144656637","https://openalex.org/W2146545950","https://openalex.org/W2548714032","https://openalex.org/W2557668530","https://openalex.org/W2626272376","https://openalex.org/W2726414492","https://openalex.org/W2750742700","https://openalex.org/W2778838015","https://openalex.org/W2950200975","https://openalex.org/W2967039833","https://openalex.org/W3006330121","https://openalex.org/W3014165712","https://openalex.org/W3023076637","https://openalex.org/W3101092195","https://openalex.org/W6629754406","https://openalex.org/W6776080201"],"related_works":["https://openalex.org/W1973509935","https://openalex.org/W4389076551","https://openalex.org/W2107855069","https://openalex.org/W2611574733","https://openalex.org/W2241641394","https://openalex.org/W2514739320","https://openalex.org/W2097992793","https://openalex.org/W2140653560","https://openalex.org/W2348831795","https://openalex.org/W4312461432"],"abstract_inverted_index":{"A":[0],"multi-objective":[1],"genetic":[2,20],"algorithm":[3,21],"is":[4,22,92,112],"applied":[5],"to":[6,18,48,104,107,117,133],"the":[7,19,59,87,121,131,140],"problem":[8],"of":[9,25,43,56,86,99,127],"identifying":[10],"genes":[11,45,88,97],"associated":[12,50],"with":[13,51,66,81,102,115],"Alzheimer's":[14],"disease.":[15,53,109],"The":[16,83,110,136],"input":[17],"a":[23,36,41,125],"set":[24,42],"centrality":[26],"measures":[27],"obtained":[28,63,74],"by":[29,75,119,124],"merging":[30],"various":[31],"biological":[32],"evidence":[33],"types":[34],"into":[35],"complex":[37],"network,":[38],"based":[39],"on":[40],"11":[44],"already":[46],"known":[47],"be":[49],"this":[52,108],"In":[54],"terms":[55],"leave-one-out":[57],"validation,":[58],"strongest":[60],"results":[61,71,137,145],"are":[62,72],"using":[64],"betweenness,":[65],"ranking":[67,85],"showing":[68],"that":[69,139],"better":[70],"sometimes":[73],"including":[76],"either":[77],"stress":[78],"or":[79],"load":[80],"betweenness.":[82],"overall":[84],"across":[89],"all":[90],"runs":[91],"examined":[93],"and":[94,129],"suggests":[95],"some":[96],"worthy":[98],"further":[100],"study":[101],"respect":[103,116],"their":[105],"link":[106],"methodology":[111,132,141],"also":[113],"evaluated":[114],"robustness":[118],"modifying":[120],"original":[122],"network":[123],"range":[126],"percentages,":[128],"applying":[130],"these":[134,147],"variations.":[135],"show":[138],"returns":[142],"very":[143],"similar":[144],"under":[146],"circumstances.":[148]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}