{"id":"https://openalex.org/W3205262328","doi":"https://doi.org/10.1109/cibcb49929.2021.9562773","title":"A comparison of multi-objective optimization algorithms to identify drug target combinations","display_name":"A comparison of multi-objective optimization algorithms to identify drug target combinations","publication_year":2021,"publication_date":"2021-10-13","ids":{"openalex":"https://openalex.org/W3205262328","doi":"https://doi.org/10.1109/cibcb49929.2021.9562773","mag":"3205262328"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb49929.2021.9562773","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb49929.2021.9562773","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081323030","display_name":"Simone Spolaor","orcid":"https://orcid.org/0000-0002-3383-367X"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Simone Spolaor","raw_affiliation_strings":["Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027486263","display_name":"Daniele M. Papetti","orcid":"https://orcid.org/0000-0002-3574-6027"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele M. Papetti","raw_affiliation_strings":["Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013723473","display_name":"Paolo Cazzaniga","orcid":"https://orcid.org/0000-0001-7780-0434"},"institutions":[{"id":"https://openalex.org/I11039511","display_name":"University of Bergamo","ror":"https://ror.org/02mbd5571","country_code":"IT","type":"education","lineage":["https://openalex.org/I11039511"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Cazzaniga","raw_affiliation_strings":["Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy"],"affiliations":[{"raw_affiliation_string":"Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I11039511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072712347","display_name":"Daniela Besozzi","orcid":"https://orcid.org/0000-0001-5532-3059"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Besozzi","raw_affiliation_strings":["Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043650939","display_name":"Marco S. Nobile","orcid":"https://orcid.org/0000-0002-7692-7203"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]},{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["IT","NL"],"is_corresponding":false,"raw_author_name":"Marco S. Nobile","raw_affiliation_strings":["Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","Department of Industrial Engineering & Innovation Sciences, Eindhoven University of Technology, Eindhoven, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Industrial Engineering & Innovation Sciences, Eindhoven University of Technology, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5081323030"],"corresponding_institution_ids":["https://openalex.org/I66752286"],"apc_list":null,"apc_paid":null,"fwci":0.148,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52941387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"165","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.67538982629776},{"id":"https://openalex.org/keywords/multi-objective-optimization","display_name":"Multi-objective optimization","score":0.5395758152008057},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5078352093696594},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5051222443580627},{"id":"https://openalex.org/keywords/fuzzy-logic","display_name":"Fuzzy logic","score":0.49311158061027527},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4304194748401642},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.41341403126716614},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.39901188015937805},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27481964230537415},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15044176578521729}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.67538982629776},{"id":"https://openalex.org/C68781425","wikidata":"https://www.wikidata.org/wiki/Q2052203","display_name":"Multi-objective optimization","level":2,"score":0.5395758152008057},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5078352093696594},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5051222443580627},{"id":"https://openalex.org/C58166","wikidata":"https://www.wikidata.org/wiki/Q224821","display_name":"Fuzzy logic","level":2,"score":0.49311158061027527},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4304194748401642},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.41341403126716614},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39901188015937805},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27481964230537415},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15044176578521729},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1109/cibcb49929.2021.9562773","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb49929.2021.9562773","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.tue.nl:openaire_cris_publications/f98cd9ab-60a8-4139-828c-a072c93cb787","is_oa":false,"landing_page_url":"https://research.tue.nl/en/publications/f98cd9ab-60a8-4139-828c-a072c93cb787","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spolaor, S, Papetti, D M, Cazzaniga, P, Besozzi, D & Nobile, M S 2021, A comparison of multi-objective optimization algorithms to identify drug target combinations. in J Hallinan, M Chetty, G R Heredia, A Shatte & S Lim (eds), 2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)., 9562773, Institute of Electrical and Electronics Engineers, 2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2021, Melbourne, Victoria, Australia, 13/10/21. https://doi.org/10.1109/CIBCB49929.2021.9562773","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:aisberg.unibg.it:10446/228571","is_oa":false,"landing_page_url":"http://hdl.handle.net/10446/228571","pdf_url":null,"source":{"id":"https://openalex.org/S4377196347","display_name":"Aisberg (University of Bergamo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11039511","host_organization_name":"University of Bergamo","host_organization_lineage":["https://openalex.org/I11039511"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:boa.unimib.it:10281/391250","is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/391250","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:iris.unive.it:10278/5004792","is_oa":false,"landing_page_url":"http://hdl.handle.net/10278/5004792","pdf_url":null,"source":{"id":"https://openalex.org/S4306402336","display_name":"ARCA (Universit\u00e0 Ca' Foscari Venezia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149461666","host_organization_name":"Ca' Foscari University of Venice","host_organization_lineage":["https://openalex.org/I149461666"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:pure.tue.nl:publications/f98cd9ab-60a8-4139-828c-a072c93cb787","is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85126482371&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Spolaor, S, Papetti, D M, Cazzaniga, P, Besozzi, D & Nobile, M S 2021, A comparison of multi-objective optimization algorithms to identify drug target combinations. in J Hallinan, M Chetty, G R Heredia, A Shatte & S Lim (eds), 2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)., 9562773, Institute of Electrical and Electronics Engineers, 2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2021, Melbourne, Victoria, Australia, 13/10/21. https://doi.org/10.1109/CIBCB49929.2021.9562773","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:tue:oai:pure.tue.nl:publications/f98cd9ab-60a8-4139-828c-a072c93cb787","is_oa":false,"landing_page_url":"https://research.tue.nl/nl/publications/f98cd9ab-60a8-4139-828c-a072c93cb787","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"info:eu-repo/semantics/conferencepaper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6899999976158142}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W571710515","https://openalex.org/W1435191252","https://openalex.org/W1506010655","https://openalex.org/W1517428985","https://openalex.org/W1562402498","https://openalex.org/W1585005850","https://openalex.org/W1585939719","https://openalex.org/W1590762254","https://openalex.org/W1857789879","https://openalex.org/W1964231591","https://openalex.org/W1972978214","https://openalex.org/W1990421110","https://openalex.org/W1992176519","https://openalex.org/W1998203489","https://openalex.org/W2017218687","https://openalex.org/W2022485595","https://openalex.org/W2024060531","https://openalex.org/W2025525377","https://openalex.org/W2030683290","https://openalex.org/W2055487725","https://openalex.org/W2061554433","https://openalex.org/W2081562576","https://openalex.org/W2081781433","https://openalex.org/W2106334424","https://openalex.org/W2123485079","https://openalex.org/W2126105956","https://openalex.org/W2143784594","https://openalex.org/W2150550712","https://openalex.org/W2152994530","https://openalex.org/W2153663712","https://openalex.org/W2162695817","https://openalex.org/W2342570779","https://openalex.org/W2463564488","https://openalex.org/W2501357522","https://openalex.org/W2531057506","https://openalex.org/W2600452401","https://openalex.org/W2613587040","https://openalex.org/W2618321737","https://openalex.org/W2722321450","https://openalex.org/W2753385986","https://openalex.org/W2774112395","https://openalex.org/W2924790278","https://openalex.org/W2941717576","https://openalex.org/W2951692764","https://openalex.org/W2990147509","https://openalex.org/W2990953931","https://openalex.org/W3005974663","https://openalex.org/W3094003808","https://openalex.org/W3130570913","https://openalex.org/W3140318448","https://openalex.org/W4249749961","https://openalex.org/W4252684946","https://openalex.org/W6630399524","https://openalex.org/W6635097213","https://openalex.org/W6738516185"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867","https://openalex.org/W2113159581"],"abstract_inverted_index":{"Combination":[0],"therapies":[1],"represent":[2],"one":[3],"of":[4,24,34,48,77,98,120,134,150,165,172,191],"the":[5,16,32,45,75,83,86,135,148,151,155,163,166,170,173,180,184,189],"most":[6,87],"effective":[7],"strategy":[8],"in":[9,71,111,154],"inducing":[10],"cancer":[11,99],"cell":[12],"death":[13],"and":[14,36,51,66,79,81,106,124,143,145,169],"reducing":[15,74],"risk":[17],"to":[18,59,67,129],"develop":[19],"drug":[20,27,113],"resistance.":[21],"The":[22,55],"identification":[23],"putative":[25],"novel":[26],"combinations,":[28],"which":[29],"typically":[30],"requires":[31],"execution":[33],"expensive":[35],"time":[37,78],"consuming":[38],"lab":[39],"experiments,":[40],"can":[41],"be":[42],"supported":[43],"by":[44],"synergistic":[46],"use":[47],"mathematical":[49],"models":[50],"multi-objective":[52,103,167],"optimization":[53,104,174],"algorithms.":[54],"computational":[56],"approach":[57],"allows":[58],"automatically":[60],"search":[61],"for":[62],"potential":[63],"therapeutic":[64],"combinations":[65],"test":[68],"their":[69,109],"effectiveness":[70],"silico,":[72],"thus":[73],"costs":[76],"money,":[80],"driving":[82],"experiments":[84],"toward":[85],"promising":[88],"therapies.":[89],"In":[90],"this":[91,192],"work,":[92],"we":[93,107,117,146],"couple":[94],"dynamic":[95],"fuzzy":[96],"modeling":[97],"cells":[100],"with":[101,122],"different":[102],"algorithm,":[105],"compare":[108,147],"performance":[110],"identifying":[112],"target":[114],"combinations.":[115],"Specifically,":[116],"perform":[118],"batches":[119],"optimizations":[121],"3":[123],"4":[125],"objective":[126],"functions":[127],"defined":[128],"achieve":[130],"a":[131],"desired":[132],"behavior":[133],"system":[136],"(e.g.,":[137],"maximize":[138],"apop-tosis":[139],"while":[140],"minimizing":[141],"necrosis":[142],"survival),":[144],"quality":[149],"solutions":[152],"included":[153],"Pareto":[156],"fronts.":[157],"Our":[158],"results":[159],"show":[160],"that":[161],"both":[162],"choice":[164],"algorithm":[168],"formulation":[171],"problem":[175],"have":[176],"an":[177],"impact":[178],"on":[179],"identified":[181],"solutions,":[182],"highlighting":[183],"strengths":[185],"as":[186,188],"well":[187],"limitations":[190],"approach.":[193]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2021-10-25T00:00:00"}