{"id":"https://openalex.org/W3205262328","doi":"https://doi.org/10.1109/cibcb49929.2021.9562773","title":"A comparison of multi-objective optimization algorithms to identify drug target combinations","display_name":"A comparison of multi-objective optimization algorithms to identify drug target combinations","publication_year":2021,"publication_date":"2021-10-13","ids":{"openalex":"https://openalex.org/W3205262328","doi":"https://doi.org/10.1109/cibcb49929.2021.9562773","mag":"3205262328"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb49929.2021.9562773","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb49929.2021.9562773","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081323030","display_name":"Simone Spolaor","orcid":"https://orcid.org/0000-0002-3383-367X"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Spolaor","raw_affiliation_strings":["Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027486263","display_name":"Daniele M. Papetti","orcid":"https://orcid.org/0000-0002-3574-6027"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele M. Papetti","raw_affiliation_strings":["Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013723473","display_name":"Paolo Cazzaniga","orcid":"https://orcid.org/0000-0001-7780-0434"},"institutions":[{"id":"https://openalex.org/I11039511","display_name":"University of Bergamo","ror":"https://ror.org/02mbd5571","country_code":"IT","type":"education","lineage":["https://openalex.org/I11039511"]},{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Cazzaniga","raw_affiliation_strings":["Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy","institution_ids":["https://openalex.org/I11039511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072712347","display_name":"Daniela Besozzi","orcid":"https://orcid.org/0000-0001-5532-3059"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Besozzi","raw_affiliation_strings":["Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Informatics Systems and Communication, University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043650939","display_name":"Marco S. Nobile","orcid":"https://orcid.org/0000-0002-7692-7203"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]},{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["IT","NL"],"is_corresponding":false,"raw_author_name":"Marco S. Nobile","raw_affiliation_strings":["Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","Department of Industrial Engineering & Innovation Sciences, Eindhoven University of Technology, Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bicocca Bioinformatics, Biostatistics and Bioimaging Centre - B4 Milano, Italy SYSBIO/ISBE.IT Centre of Systems Biology, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Industrial Engineering & Innovation Sciences, Eindhoven University of Technology, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4048,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53542207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"165","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.67538982629776},{"id":"https://openalex.org/keywords/multi-objective-optimization","display_name":"Multi-objective optimization","score":0.5395758152008057},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5078352093696594},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5051222443580627},{"id":"https://openalex.org/keywords/fuzzy-logic","display_name":"Fuzzy logic","score":0.49311158061027527},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4304194748401642},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.41341403126716614},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.39901188015937805},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27481964230537415},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15044176578521729}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.67538982629776},{"id":"https://openalex.org/C68781425","wikidata":"https://www.wikidata.org/wiki/Q2052203","display_name":"Multi-objective optimization","level":2,"score":0.5395758152008057},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5078352093696594},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5051222443580627},{"id":"https://openalex.org/C58166","wikidata":"https://www.wikidata.org/wiki/Q224821","display_name":"Fuzzy logic","level":2,"score":0.49311158061027527},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4304194748401642},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.41341403126716614},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39901188015937805},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27481964230537415},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15044176578521729},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1109/cibcb49929.2021.9562773","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb49929.2021.9562773","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.tue.nl:openaire_cris_publications/f98cd9ab-60a8-4139-828c-a072c93cb787","is_oa":false,"landing_page_url":"https://research.tue.nl/en/publications/f98cd9ab-60a8-4139-828c-a072c93cb787","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:aisberg.unibg.it:10446/228571","is_oa":false,"landing_page_url":"http://hdl.handle.net/10446/228571","pdf_url":null,"source":{"id":"https://openalex.org/S4377196347","display_name":"Aisberg (University of Bergamo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11039511","host_organization_name":"University of Bergamo","host_organization_lineage":["https://openalex.org/I11039511"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:boa.unimib.it:10281/391250","is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/391250","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:iris.unive.it:10278/5004792","is_oa":false,"landing_page_url":"http://hdl.handle.net/10278/5004792","pdf_url":null,"source":{"id":"https://openalex.org/S4306402336","display_name":"ARCA (Universit\u00e0 Ca' Foscari Venezia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149461666","host_organization_name":"Ca' Foscari University of Venice","host_organization_lineage":["https://openalex.org/I149461666"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:tue:oai:pure.tue.nl:publications/f98cd9ab-60a8-4139-828c-a072c93cb787","is_oa":false,"landing_page_url":"https://research.tue.nl/nl/publications/f98cd9ab-60a8-4139-828c-a072c93cb787","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2021 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"info:eu-repo/semantics/conferencepaper"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W571710515","https://openalex.org/W1435191252","https://openalex.org/W1506010655","https://openalex.org/W1517428985","https://openalex.org/W1562402498","https://openalex.org/W1585005850","https://openalex.org/W1585939719","https://openalex.org/W1590762254","https://openalex.org/W1857789879","https://openalex.org/W1964231591","https://openalex.org/W1972978214","https://openalex.org/W1990421110","https://openalex.org/W1992176519","https://openalex.org/W1998203489","https://openalex.org/W2017218687","https://openalex.org/W2022485595","https://openalex.org/W2024060531","https://openalex.org/W2025525377","https://openalex.org/W2030683290","https://openalex.org/W2055487725","https://openalex.org/W2061554433","https://openalex.org/W2081562576","https://openalex.org/W2081781433","https://openalex.org/W2106334424","https://openalex.org/W2123485079","https://openalex.org/W2126105956","https://openalex.org/W2143784594","https://openalex.org/W2150550712","https://openalex.org/W2152994530","https://openalex.org/W2153663712","https://openalex.org/W2162695817","https://openalex.org/W2342570779","https://openalex.org/W2463564488","https://openalex.org/W2501357522","https://openalex.org/W2531057506","https://openalex.org/W2600452401","https://openalex.org/W2613587040","https://openalex.org/W2618321737","https://openalex.org/W2722321450","https://openalex.org/W2753385986","https://openalex.org/W2774112395","https://openalex.org/W2924790278","https://openalex.org/W2941717576","https://openalex.org/W2951692764","https://openalex.org/W2990147509","https://openalex.org/W2990953931","https://openalex.org/W3005974663","https://openalex.org/W3094003808","https://openalex.org/W3130570913","https://openalex.org/W3140318448","https://openalex.org/W4249749961","https://openalex.org/W4252684946","https://openalex.org/W6630399524","https://openalex.org/W6635097213","https://openalex.org/W6738516185"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867","https://openalex.org/W2113159581"],"abstract_inverted_index":{"Combination":[0],"therapies":[1],"represent":[2],"one":[3],"of":[4,24,34,48,77,98,120,134,150,165,172,191],"the":[5,16,32,45,75,83,86,135,148,151,155,163,166,170,173,180,184,189],"most":[6,87],"effective":[7],"strategy":[8],"in":[9,71,111,154],"inducing":[10],"cancer":[11,99],"cell":[12],"death":[13],"and":[14,36,51,66,79,81,106,124,143,145,169],"reducing":[15,74],"risk":[17],"to":[18,59,67,129],"develop":[19],"drug":[20,27,113],"resistance.":[21],"The":[22,55],"identification":[23],"putative":[25],"novel":[26],"combinations,":[28],"which":[29],"typically":[30],"requires":[31],"execution":[33],"expensive":[35],"time":[37,78],"consuming":[38],"lab":[39],"experiments,":[40],"can":[41],"be":[42],"supported":[43],"by":[44],"synergistic":[46],"use":[47],"mathematical":[49],"models":[50],"multi-objective":[52,103,167],"optimization":[53,104,174],"algorithms.":[54],"computational":[56],"approach":[57],"allows":[58],"automatically":[60],"search":[61],"for":[62],"potential":[63],"therapeutic":[64],"combinations":[65],"test":[68],"their":[69,109],"effectiveness":[70],"silico,":[72],"thus":[73],"costs":[76],"money,":[80],"driving":[82],"experiments":[84],"toward":[85],"promising":[88],"therapies.":[89],"In":[90],"this":[91,192],"work,":[92],"we":[93,107,117,146],"couple":[94],"dynamic":[95],"fuzzy":[96],"modeling":[97],"cells":[100],"with":[101,122],"different":[102],"algorithm,":[105],"compare":[108,147],"performance":[110],"identifying":[112],"target":[114],"combinations.":[115],"Specifically,":[116],"perform":[118],"batches":[119],"optimizations":[121],"3":[123],"4":[125],"objective":[126],"functions":[127],"defined":[128],"achieve":[130],"a":[131],"desired":[132],"behavior":[133],"system":[136],"(e.g.,":[137],"maximize":[138],"apop-tosis":[139],"while":[140],"minimizing":[141],"necrosis":[142],"survival),":[144],"quality":[149],"solutions":[152],"included":[153],"Pareto":[156],"fronts.":[157],"Our":[158],"results":[159],"show":[160],"that":[161],"both":[162],"choice":[164],"algorithm":[168],"formulation":[171],"problem":[175],"have":[176],"an":[177],"impact":[178],"on":[179],"identified":[181],"solutions,":[182],"highlighting":[183],"strengths":[185],"as":[186,188],"well":[187],"limitations":[190],"approach.":[193]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2021-10-25T00:00:00"}
