{"id":"https://openalex.org/W2968231321","doi":"https://doi.org/10.1109/cibcb.2019.8791488","title":"Determining structural parameter identifiability in biological dynamical models by analysing the statistical properties of the likelihood behaviour","display_name":"Determining structural parameter identifiability in biological dynamical models by analysing the statistical properties of the likelihood behaviour","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2968231321","doi":"https://doi.org/10.1109/cibcb.2019.8791488","mag":"2968231321"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb.2019.8791488","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2019.8791488","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039627791","display_name":"Angela Re","orcid":"https://orcid.org/0000-0002-3179-6967"},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Re","raw_affiliation_strings":["Systems and Synthetic Biology Laboratory, Fondazione Istituto Italiano di Tecnologia, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems and Synthetic Biology Laboratory, Fondazione Istituto Italiano di Tecnologia, Torino, Italy","institution_ids":["https://openalex.org/I30771326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047664773","display_name":"Paola Lecca","orcid":"https://orcid.org/0000-0002-7224-136X"},"institutions":[{"id":"https://openalex.org/I160013858","display_name":"Istituto Nazionale di Fisica Nucleare","ror":"https://ror.org/005ta0471","country_code":"IT","type":"government","lineage":["https://openalex.org/I160013858"]},{"id":"https://openalex.org/I4210093299","display_name":"Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics And Applications","ror":"https://ror.org/00nhs3j29","country_code":"IT","type":"facility","lineage":["https://openalex.org/I160013858","https://openalex.org/I193223587","https://openalex.org/I4210093299"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Lecca","raw_affiliation_strings":["National Institute for Nuclear Physics, Trento Institute for Fundamental Physics and Applications"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Nuclear Physics, Trento Institute for Fundamental Physics and Applications","institution_ids":["https://openalex.org/I4210093299","https://openalex.org/I160013858"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08708084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10876","display_name":"Fault Detection and Control Systems","score":0.9745000004768372,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.9845010042190552},{"id":"https://openalex.org/keywords/likelihood-function","display_name":"Likelihood function","score":0.6937263011932373},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.598015308380127},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5662504434585571},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.5278727412223816},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.5277469754219055},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5166168808937073},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.46474191546440125},{"id":"https://openalex.org/keywords/maximum-likelihood","display_name":"Maximum likelihood","score":0.45780372619628906},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45391231775283813},{"id":"https://openalex.org/keywords/precondition","display_name":"Precondition","score":0.44886457920074463},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4460695683956146},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.4325331449508667},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.34143155813217163}],"concepts":[{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.9845010042190552},{"id":"https://openalex.org/C89106044","wikidata":"https://www.wikidata.org/wiki/Q45284","display_name":"Likelihood function","level":3,"score":0.6937263011932373},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.598015308380127},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5662504434585571},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.5278727412223816},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.5277469754219055},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5166168808937073},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.46474191546440125},{"id":"https://openalex.org/C49781872","wikidata":"https://www.wikidata.org/wiki/Q1045555","display_name":"Maximum likelihood","level":2,"score":0.45780372619628906},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45391231775283813},{"id":"https://openalex.org/C192465680","wikidata":"https://www.wikidata.org/wiki/Q1413450","display_name":"Precondition","level":2,"score":0.44886457920074463},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4460695683956146},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4325331449508667},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.34143155813217163},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/cibcb.2019.8791488","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2019.8791488","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},{"id":"pmh:oai:alma.39UBZ_INST:11283278130001241","is_oa":false,"landing_page_url":"https://ieeexplore.ieee.org/abstract/document/8791488","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"View","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:iris.unitn.it:11572/240918","is_oa":false,"landing_page_url":"http://hdl.handle.net/11572/240918","pdf_url":null,"source":{"id":"https://openalex.org/S4306401913","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Trento)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193223587","host_organization_name":"University of Trento","host_organization_lineage":["https://openalex.org/I193223587"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:unibz.it:11283278130001241","is_oa":false,"landing_page_url":"https://bia.unibz.it/esploro/outputs/conferenceProceeding/Determining-structural-parameter-identifiability-in-biological/991006414096101241","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"View","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1992476963","https://openalex.org/W1994695086","https://openalex.org/W2003195392","https://openalex.org/W2059246518","https://openalex.org/W2077298225","https://openalex.org/W2077480167","https://openalex.org/W2100659437","https://openalex.org/W2124822779","https://openalex.org/W2133068979","https://openalex.org/W2168648059","https://openalex.org/W2338895903","https://openalex.org/W2477731233","https://openalex.org/W2554987818","https://openalex.org/W2587775733","https://openalex.org/W2595507107","https://openalex.org/W2607044251","https://openalex.org/W2610850891","https://openalex.org/W2611216337","https://openalex.org/W2724107504","https://openalex.org/W2733001227","https://openalex.org/W2746765822","https://openalex.org/W2772955743","https://openalex.org/W2792173551","https://openalex.org/W2808873024","https://openalex.org/W2884184895","https://openalex.org/W2902372013","https://openalex.org/W2905083628","https://openalex.org/W2914780505","https://openalex.org/W2917843259","https://openalex.org/W2949814822","https://openalex.org/W4391678844","https://openalex.org/W6733555650","https://openalex.org/W6756780172"],"related_works":["https://openalex.org/W1974129636","https://openalex.org/W2552635486","https://openalex.org/W1598584175","https://openalex.org/W3006948849","https://openalex.org/W3214883977","https://openalex.org/W1998523300","https://openalex.org/W2173736524","https://openalex.org/W1972488940","https://openalex.org/W2130590832","https://openalex.org/W2120595071"],"abstract_inverted_index":{"Identifiability":[0],"is":[1,56],"a":[2,18,37,54,63],"fundamental":[3],"precondition":[4],"for":[5,26],"model":[6,20,28,43,55],"identification":[7],"and":[8,22],"concerns":[9],"the":[10,23,27,40,46,49,59,68,74,80,84,87,92,100,111],"possibility":[11],"to":[12,36],"determine":[13],"unique":[14,64],"parameters":[15,44],"sets":[16],"using":[17],"certain":[19],"structure":[21],"experimental":[24,95],"observations":[25],"input-output.":[29],"In":[30],"this":[31,103],"article":[32],"we":[33],"show":[34,99],"how":[35],"priori":[38],"assess":[39],"identifiability":[41,112],"of":[42,48,73,86,102,107],"analysing":[45],"properties":[47],"likelihood":[50,60,75,81],"function.":[51],"More":[52],"precisely,":[53],"identifiable":[57],"if":[58],"function":[61,76],"shows":[62],"absolute":[65],"minimum":[66],"beyond":[67],"confidence":[69,88],"intervals.":[70],"The":[71],"study":[72],"cannot":[77],"avoid":[78],"accompanying":[79],"estimates":[82],"with":[83],"assessment":[85],"intervals,":[89],"which":[90],"reflect":[91],"variability":[93],"in":[94,105],"data.":[96],"We":[97],"then":[98],"results":[101],"approach":[104],"cases":[106],"biotechnological":[108],"relevance":[109],"where":[110],"has":[113],"been":[114],"previously":[115],"assessed.":[116]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
