{"id":"https://openalex.org/W1988123909","doi":"https://doi.org/10.1109/cibcb.2012.6217255","title":"Utilizing stochastic model checking to analyze genetic circuits","display_name":"Utilizing stochastic model checking to analyze genetic circuits","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W1988123909","doi":"https://doi.org/10.1109/cibcb.2012.6217255","mag":"1988123909"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb.2012.6217255","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2012.6217255","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047908665","display_name":"Curtis Madsen","orcid":"https://orcid.org/0000-0002-0254-0364"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Madsen","raw_affiliation_strings":["University of Utah, Salt Lake, UT, USA","University of Utah, Salt Lake City, 84112, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, 84112, USA#TAB#","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111386695","display_name":"Chris J. Myers","orcid":null},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. J. Myers","raw_affiliation_strings":["University of Utah, Salt Lake, UT, USA","University of Utah, Salt Lake City, 84112, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, 84112, USA#TAB#","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082955901","display_name":"Nicholas Roehner","orcid":"https://orcid.org/0000-0003-4957-1552"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Roehner","raw_affiliation_strings":["University of Utah, Salt Lake, UT, USA","University of Utah, Salt Lake City, 84112, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, 84112, USA#TAB#","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103171582","display_name":"Chris Winstead","orcid":"https://orcid.org/0000-0001-5238-5852"},"institutions":[{"id":"https://openalex.org/I121980950","display_name":"Utah State University","ror":"https://ror.org/00h6set76","country_code":"US","type":"education","lineage":["https://openalex.org/I121980950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Winstead","raw_affiliation_strings":["Utah State University, Logan, UT, USA","Utah State University, Logan, 84322, USA"],"affiliations":[{"raw_affiliation_string":"Utah State University, Logan, UT, USA","institution_ids":["https://openalex.org/I121980950"]},{"raw_affiliation_string":"Utah State University, Logan, 84322, USA","institution_ids":["https://openalex.org/I121980950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100662940","display_name":"Zhen Zhang","orcid":"https://orcid.org/0000-0001-9866-4523"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Zhang","raw_affiliation_strings":["University of Utah, Salt Lake, UT, USA","University of Utah, Salt Lake City, 84112, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake, UT, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, 84112, USA#TAB#","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047908665"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":1.3445,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79114863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"379","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9799000024795532,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6497889161109924},{"id":"https://openalex.org/keywords/model-checking","display_name":"Model checking","score":0.5001354217529297},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.4275176227092743},{"id":"https://openalex.org/keywords/stochastic-modelling","display_name":"Stochastic modelling","score":0.4197912812232971},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.27711063623428345},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12282401323318481},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10602778196334839},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10217952728271484},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.06574296951293945}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6497889161109924},{"id":"https://openalex.org/C110251889","wikidata":"https://www.wikidata.org/wiki/Q1569697","display_name":"Model checking","level":2,"score":0.5001354217529297},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.4275176227092743},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.4197912812232971},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.27711063623428345},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12282401323318481},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10602778196334839},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10217952728271484},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.06574296951293945}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cibcb.2012.6217255","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2012.6217255","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)","raw_type":"proceedings-article"},{"id":"pmh:oai:digitalcommons.usu.edu:ece_facpub-1149","is_oa":false,"landing_page_url":"https://digitalcommons.usu.edu/ece_facpub/147","pdf_url":null,"source":{"id":"https://openalex.org/S4377196327","display_name":"Digital Commons - USU (Utah State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121980950","host_organization_name":"Utah State University","host_organization_lineage":["https://openalex.org/I121980950"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electrical and Computer Engineering Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W35463602","https://openalex.org/W1514324734","https://openalex.org/W1516256348","https://openalex.org/W1535517661","https://openalex.org/W1573985420","https://openalex.org/W1859458367","https://openalex.org/W1890385119","https://openalex.org/W1970221707","https://openalex.org/W1974272479","https://openalex.org/W1989284002","https://openalex.org/W1989431662","https://openalex.org/W1997982531","https://openalex.org/W2007072455","https://openalex.org/W2011432832","https://openalex.org/W2018075920","https://openalex.org/W2029370898","https://openalex.org/W2034375827","https://openalex.org/W2041226400","https://openalex.org/W2045095831","https://openalex.org/W2047575149","https://openalex.org/W2047882868","https://openalex.org/W2077480167","https://openalex.org/W2078734278","https://openalex.org/W2088846696","https://openalex.org/W2091167328","https://openalex.org/W2101506009","https://openalex.org/W2109082753","https://openalex.org/W2129064518","https://openalex.org/W2134759932","https://openalex.org/W2147306790","https://openalex.org/W2150908245","https://openalex.org/W2153517004","https://openalex.org/W2155418451","https://openalex.org/W2158979830","https://openalex.org/W2256672332","https://openalex.org/W2605543710","https://openalex.org/W4243003743","https://openalex.org/W4292425548","https://openalex.org/W6630765387","https://openalex.org/W6632056543","https://openalex.org/W6639397836"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W4391913857","https://openalex.org/W2350741829","https://openalex.org/W2530322880"],"abstract_inverted_index":{"When":[0],"designing":[1],"and":[2,38,185],"analyzing":[3,39],"genetic":[4,54,129,182],"circuits,":[5],"researchers":[6,62],"are":[7],"often":[8],"interested":[9],"in":[10,103,160,180,204],"the":[11,14,30,44,49,66,78,87,97,121,150,153,176],"probability":[12],"of":[13,24,51,53,77,89,123,164,171,178,193],"system":[15,31],"reaching":[16],"a":[17,21,93,104,124,128,134,156,161,169,181,205],"given":[18,157],"state":[19,45],"within":[20],"certain":[22,100],"amount":[23,163],"time.":[25,165],"Usually,":[26],"this":[27,40,82,84,172,194,201],"involves":[28],"simulating":[29],"to":[32,42,63,112,148,174,189],"produce":[33],"some":[34],"time":[35,73],"series":[36,74],"data":[37,41],"discern":[43],"probabilities.":[46],"However,":[47],"as":[48,208],"complexity":[50],"models":[52],"circuits":[55],"grow,":[56],"it":[57],"becomes":[58],"more":[59],"difficult":[60],"for":[61,95,126],"reason":[64],"about":[65],"different":[67],"states":[68],"by":[69,120],"looking":[70],"only":[71],"at":[72],"simulation":[75],"results":[76,188,198,203],"models.":[79],"To":[80],"address":[81],"problem,":[83],"paper":[85,167],"employs":[86],"use":[88,170],"stochastic":[90,108,190],"model":[91,131],"checking,":[92],"method":[94,202],"determining":[96],"likelihood":[98,151,177],"that":[99,152,200],"events":[101],"occur":[102],"system,":[105],"with":[106,210],"continuous":[107],"logic":[109],"(CSL)":[110],"properties":[111],"obtain":[113],"similar":[114],"results.":[115],"This":[116,139,166],"goal":[117],"is":[118,141],"accomplished":[119],"introduction":[122],"methodology":[125,173],"converting":[127],"circuit":[130,154],"(GCM)":[132],"into":[133],"continuous-time":[135],"Markov":[136,145],"chain":[137,146],"(CTMC).":[138],"CTMC":[140],"analyzed":[142],"using":[143],"transient":[144],"analysis":[147,192],"determine":[149,175],"satisfies":[155],"CSL":[158],"property":[159],"finite":[162],"illustrates":[168],"failure":[179],"toggle":[183],"switch":[184],"compares":[186],"these":[187],"simulation-based":[191,212],"same":[195],"circuit.":[196],"Our":[197],"show":[199],"substantial":[206],"speedup":[207],"compared":[209],"conventional":[211],"approaches.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}