{"id":"https://openalex.org/W2127095744","doi":"https://doi.org/10.1109/cibcb.2007.4221257","title":"Using Drosophila melanogaster Data to Discover Disease-Related Protein Interactions in Humans","display_name":"Using Drosophila melanogaster Data to Discover Disease-Related Protein Interactions in Humans","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W2127095744","doi":"https://doi.org/10.1109/cibcb.2007.4221257","mag":"2127095744"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb.2007.4221257","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2007.4221257","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035378993","display_name":"James C. Costello","orcid":"https://orcid.org/0000-0003-3158-9682"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.C. Costello","raw_affiliation_strings":["School of Informatics, Indiana University, Bloomington, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics, Indiana University, Bloomington, IN, USA","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090438842","display_name":"Jade Carter","orcid":"https://orcid.org/0000-0003-2792-1662"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.E. Buchanan-Carter","raw_affiliation_strings":["School of Informatics, Indiana University, Bloomington, IN 47405; Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","School of Informatics, Indiana University, Bloomington, IN 47405","Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics, Indiana University, Bloomington, IN 47405; Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"School of Informatics, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081672389","display_name":"Mehmet Dalk\u0131l\u0131\u00e7","orcid":"https://orcid.org/0000-0002-0776-7365"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.M. Dalkilic","raw_affiliation_strings":["School of Informatics, Indiana University, Bloomington, IN 47405; Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","School of Informatics, Indiana University, Bloomington, IN 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Informatics, Indiana University, Bloomington, IN 47405; Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"School of Informatics, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005430422","display_name":"Justen Andrews","orcid":null},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Andrews","raw_affiliation_strings":["Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405; Drosophila Genome Resource Center, Indiana University, Bloomington, IN 47405; Department of Biology, Indiana University, Bloomington, IN 47405","Department of Biology, Indiana University, Bloomington, IN 47405","Drosophila Genome Resource Center, Indiana University, Bloomington, IN 47405","Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405; Drosophila Genome Resource Center, Indiana University, Bloomington, IN 47405; Department of Biology, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Drosophila Genome Resource Center, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405","institution_ids":["https://openalex.org/I4210119109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210119109"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"297","issue":null,"first_page":"469","last_page":"475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8972209692001343},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.6226603388786316},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5747250914573669},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5478368997573853},{"id":"https://openalex.org/keywords/human-disease","display_name":"Human disease","score":0.528774619102478},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.4497603178024292},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila (subgenus)","score":0.4479495882987976},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4373909533023834},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42003610730171204},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.41873544454574585},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.38640478253364563},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28565967082977295},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10225573182106018}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.8972209692001343},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.6226603388786316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5747250914573669},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5478368997573853},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.528774619102478},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4497603178024292},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.4479495882987976},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4373909533023834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42003610730171204},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41873544454574585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38640478253364563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28565967082977295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10225573182106018},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb.2007.4221257","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2007.4221257","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1536234254","https://openalex.org/W1576520375","https://openalex.org/W1967582843","https://openalex.org/W1976952616","https://openalex.org/W2003831408","https://openalex.org/W2017139829","https://openalex.org/W2021224973","https://openalex.org/W2021743398","https://openalex.org/W2025922492","https://openalex.org/W2029375851","https://openalex.org/W2036437741","https://openalex.org/W2041358828","https://openalex.org/W2041404754","https://openalex.org/W2052074166","https://openalex.org/W2055043387","https://openalex.org/W2074027785","https://openalex.org/W2074814295","https://openalex.org/W2079818352","https://openalex.org/W2083752219","https://openalex.org/W2103017472","https://openalex.org/W2105581244","https://openalex.org/W2106013076","https://openalex.org/W2111844766","https://openalex.org/W2119043225","https://openalex.org/W2119412782","https://openalex.org/W2124463526","https://openalex.org/W2127563440","https://openalex.org/W2128207349","https://openalex.org/W2128923603","https://openalex.org/W2130722975","https://openalex.org/W2135544680","https://openalex.org/W2137464714","https://openalex.org/W2138203479","https://openalex.org/W2139780906","https://openalex.org/W2140591044","https://openalex.org/W2144014661","https://openalex.org/W2149639380","https://openalex.org/W2150233912","https://openalex.org/W2151875636","https://openalex.org/W2157363882","https://openalex.org/W2158930854","https://openalex.org/W2164362099","https://openalex.org/W2164813401","https://openalex.org/W2167188257","https://openalex.org/W2168048337","https://openalex.org/W2170628952","https://openalex.org/W4236236547","https://openalex.org/W4248234957"],"related_works":["https://openalex.org/W4323037479","https://openalex.org/W4311607074","https://openalex.org/W3025486376","https://openalex.org/W3166827729","https://openalex.org/W2236776555","https://openalex.org/W2753303236","https://openalex.org/W2082613811","https://openalex.org/W4390801875","https://openalex.org/W4400352626","https://openalex.org/W2035689692"],"abstract_inverted_index":{"The":[0],"discovery":[1],"and":[2,9,30,89,106],"understanding":[3,17],"of":[4,18,53,111],"functional":[5],"relationships":[6,46,64,82],"amongst":[7],"genes":[8],"their":[10],"gene":[11],"products":[12],"are":[13,27,83],"fundamental":[14],"to":[15,43,61,69,104],"our":[16,112],"human":[19,66,86],"disease.":[20,70],"Data":[21],"regarding":[22],"protein-protein":[23,63,78],"interactions":[24],"in":[25,47],"humans":[26],"not":[28],"complete":[29],"computational":[31],"techniques":[32],"along":[33],"with":[34],"data":[35,57],"provided":[36],"from":[37,58],"other":[38],"organisms":[39],"can":[40],"be":[41],"used":[42],"better":[44],"inform":[45],"humans.":[48],"We":[49],"demonstrate":[50],"the":[51,73,80,109],"utility":[52],"using":[54],"genome":[55],"scale":[56],"Drosophila":[59],"melanogaster":[60],"predict":[62],"for":[65,77],"proteins":[67],"specific":[68],"To":[71],"find":[72],"most":[74],"likely":[75],"candidates":[76],"interaction,":[79],"predicted":[81],"tested":[84],"against":[85],"protein":[87],"interaction":[88],"known":[90],"disease":[91],"data,":[92],"then":[93],"ranked":[94],"through":[95],"a":[96],"support":[97],"vector":[98],"machine.":[99],"An":[100],"illustrative":[101],"example":[102],"related":[103],"hBrm":[105],"hSNF5":[107],"shows":[108],"validity":[110],"approach":[113]},"counts_by_year":[],"updated_date":"2026-07-25T09:21:30.201066","created_date":"2025-10-10T00:00:00"}