{"id":"https://openalex.org/W2120669962","doi":"https://doi.org/10.1109/cibcb.2007.4221234","title":"Computational Prediction of Replication Origins in Herpesviruses","display_name":"Computational Prediction of Replication Origins in Herpesviruses","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W2120669962","doi":"https://doi.org/10.1109/cibcb.2007.4221234","mag":"2120669962"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb.2007.4221234","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2007.4221234","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059475820","display_name":"Raul Cruz\u2010Cano","orcid":"https://orcid.org/0000-0001-7715-1198"},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Cruz-Cano","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Texas, El Paso, El Paso, TX, USA","Bioinformatics Program, Texas Univ., El Paso, TX"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Texas, El Paso, El Paso, TX, USA","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Bioinformatics Program, Texas Univ., El Paso, TX","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112008517","display_name":"Dev Chandran","orcid":null},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Chandran","raw_affiliation_strings":["University of Texas, El Paso, El Paso, TX, USA","Bioinformatics Program, Texas Univ., El Paso, TX"],"affiliations":[{"raw_affiliation_string":"University of Texas, El Paso, El Paso, TX, USA","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Bioinformatics Program, Texas Univ., El Paso, TX","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040135909","display_name":"Ming\u2010Ying Leung","orcid":"https://orcid.org/0000-0003-2035-1214"},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Ying Leung","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Texas, El Paso, El Paso, TX, USA","Bioinformatics Program, Texas Univ., El Paso, TX"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Texas, El Paso, El Paso, TX, USA","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Bioinformatics Program, Texas Univ., El Paso, TX","institution_ids":["https://openalex.org/I164936912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059475820"],"corresponding_institution_ids":["https://openalex.org/I164936912"],"apc_list":null,"apc_paid":null,"fwci":0.442,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65510775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"89","issue":null,"first_page":"283","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.7479114532470703},{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.7228043675422668},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6859884858131409},{"id":"https://openalex.org/keywords/palindrome","display_name":"Palindrome","score":0.6296825408935547},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6041603684425354},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.576846718788147},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4679485857486725},{"id":"https://openalex.org/keywords/computational-complexity-theory","display_name":"Computational complexity theory","score":0.42531290650367737},{"id":"https://openalex.org/keywords/origin-of-replication","display_name":"Origin of replication","score":0.4165409803390503},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33533066511154175},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.30570825934410095},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23581194877624512},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16072925925254822},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09341365098953247}],"concepts":[{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.7479114532470703},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.7228043675422668},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6859884858131409},{"id":"https://openalex.org/C44667518","wikidata":"https://www.wikidata.org/wiki/Q12321","display_name":"Palindrome","level":4,"score":0.6296825408935547},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6041603684425354},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.576846718788147},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4679485857486725},{"id":"https://openalex.org/C179799912","wikidata":"https://www.wikidata.org/wiki/Q205084","display_name":"Computational complexity theory","level":2,"score":0.42531290650367737},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.4165409803390503},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33533066511154175},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.30570825934410095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23581194877624512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16072925925254822},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09341365098953247},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb.2007.4221234","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2007.4221234","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W7934179","https://openalex.org/W150571132","https://openalex.org/W1496024578","https://openalex.org/W1517114175","https://openalex.org/W1606265854","https://openalex.org/W1731704781","https://openalex.org/W1801988245","https://openalex.org/W1832545641","https://openalex.org/W1888245696","https://openalex.org/W1965534409","https://openalex.org/W1982227872","https://openalex.org/W1988035696","https://openalex.org/W1995317488","https://openalex.org/W1995980397","https://openalex.org/W2002096058","https://openalex.org/W2030976750","https://openalex.org/W2034285658","https://openalex.org/W2044498524","https://openalex.org/W2052812603","https://openalex.org/W2088082060","https://openalex.org/W2090432153","https://openalex.org/W2101414295","https://openalex.org/W2102934738","https://openalex.org/W2114234345","https://openalex.org/W2114879373","https://openalex.org/W2119423166","https://openalex.org/W2129639697","https://openalex.org/W2142294062","https://openalex.org/W2142705391","https://openalex.org/W2145872581","https://openalex.org/W2148694408","https://openalex.org/W2155482699","https://openalex.org/W2166720212","https://openalex.org/W2906687290","https://openalex.org/W4246285604","https://openalex.org/W4292023222","https://openalex.org/W6675189261","https://openalex.org/W6679455835"],"related_works":["https://openalex.org/W4214506306","https://openalex.org/W2940487742","https://openalex.org/W4323366524","https://openalex.org/W1980577621","https://openalex.org/W2477304139","https://openalex.org/W1986616196","https://openalex.org/W1633876340","https://openalex.org/W2619402950","https://openalex.org/W2580705150","https://openalex.org/W2313796638"],"abstract_inverted_index":{"Computational":[0],"methods":[1],"for":[2,81],"replication":[3,61],"origin":[4],"prediction":[5,74,99,109],"in":[6,30],"individual":[7],"herpesvirus":[8],"genomes":[9],"have":[10],"been":[11],"previously":[12],"devised":[13],"based":[14,92],"on":[15],"the":[16,57,65,69,77,90,98,103,108],"locations":[17],"of":[18,21,28,35,59,76,89,97],"high":[19],"concentrations":[20],"palindromes.":[22],"In":[23],"order":[24],"to":[25,64],"make":[26],"use":[27],"similarities":[29],"genome":[31,66],"composition":[32],"and":[33,68],"organization":[34],"related":[36],"herpesviruses,":[37],"an":[38],"artificial":[39,48],"neural":[40,49,78],"network":[41,79],"approach":[42,80],"is":[43,85],"explored.":[44],"We":[45],"implement":[46],"feed-forward":[47],"networks":[50],"trained":[51],"by":[52,102,112],"17":[53],"input":[54],"variables":[55],"comprising":[56],"positions":[58],"known":[60],"origins":[62],"relative":[63],"lengths":[67],"dinucleotide":[70],"scores.":[71],"The":[72],"overall":[73],"accuracy":[75,110],"our":[82],"data":[83],"set":[84],"better":[86],"than":[87],"that":[88],"palindrome":[91],"approach.":[93],"Furthermore,":[94],"suitable":[95],"combinations":[96],"results":[100],"given":[101],"two":[104],"approaches":[105],"substantially":[106],"increase":[107],"achieved":[111],"either":[113],"method":[114],"applied":[115],"individually.":[116]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}