{"id":"https://openalex.org/W1540350410","doi":"https://doi.org/10.1109/cibcb.2004.1393959","title":"Evolutionary optimization of interval rules for drug design","display_name":"Evolutionary optimization of interval rules for drug design","publication_year":2005,"publication_date":"2005-03-21","ids":{"openalex":"https://openalex.org/W1540350410","doi":"https://doi.org/10.1109/cibcb.2004.1393959","mag":"1540350410"},"language":"en","primary_location":{"id":"doi:10.1109/cibcb.2004.1393959","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2004.1393959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IGARSS 2004. 2004 IEEE International Geoscience and Remote Sensing (IEEE Cat. No.04CH37612)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113930837","display_name":"J\u00fcrgen Paetz","orcid":null},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J. Paetz","raw_affiliation_strings":["Molecular Design Laboratory, Institute of Organic Chemistry and Chemical Biology, Department of Chemical and Pharmaceutical Science, J. W. Goethe Universit\u00e4t Frankfurt, Frankfurt, Germany","Dept. of Chem. & Pharm. Sci., J. W. Goethe-Univ. Frankfurt am Main, Germany"],"affiliations":[{"raw_affiliation_string":"Molecular Design Laboratory, Institute of Organic Chemistry and Chemical Biology, Department of Chemical and Pharmaceutical Science, J. W. Goethe Universit\u00e4t Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Dept. of Chem. & Pharm. Sci., J. W. Goethe-Univ. Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113930837"],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":null,"apc_paid":null,"fwci":2.6325,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.90100289,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":null,"first_page":"238","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10820","display_name":"Fuzzy Logic and Control Systems","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10100","display_name":"Metaheuristic Optimization Algorithms Research","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.7751624584197998},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7399000525474548},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6182640194892883},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5977039337158203},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5807932615280151},{"id":"https://openalex.org/keywords/evolutionary-computation","display_name":"Evolutionary computation","score":0.5434033274650574},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5274760127067566},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4845558702945709},{"id":"https://openalex.org/keywords/interval","display_name":"Interval (graph theory)","score":0.44701212644577026},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.43855318427085876},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3775996267795563},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.167409747838974},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.09685149788856506},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09048700332641602},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08646693825721741},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08370354771614075}],"concepts":[{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.7751624584197998},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7399000525474548},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6182640194892883},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5977039337158203},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5807932615280151},{"id":"https://openalex.org/C105902424","wikidata":"https://www.wikidata.org/wiki/Q1197129","display_name":"Evolutionary computation","level":2,"score":0.5434033274650574},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5274760127067566},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4845558702945709},{"id":"https://openalex.org/C2778067643","wikidata":"https://www.wikidata.org/wiki/Q166507","display_name":"Interval (graph theory)","level":2,"score":0.44701212644577026},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.43855318427085876},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3775996267795563},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.167409747838974},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.09685149788856506},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09048700332641602},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08646693825721741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08370354771614075},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cibcb.2004.1393959","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cibcb.2004.1393959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IGARSS 2004. 2004 IEEE International Geoscience and Remote Sensing (IEEE Cat. No.04CH37612)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W92539380","https://openalex.org/W281235310","https://openalex.org/W1484413656","https://openalex.org/W1534872821","https://openalex.org/W1545231783","https://openalex.org/W1602589614","https://openalex.org/W1969837365","https://openalex.org/W1984748493","https://openalex.org/W2001072463","https://openalex.org/W2001284100","https://openalex.org/W2010429723","https://openalex.org/W2014797612","https://openalex.org/W2022547970","https://openalex.org/W2025285855","https://openalex.org/W2031372687","https://openalex.org/W2047509756","https://openalex.org/W2066393173","https://openalex.org/W2071958671","https://openalex.org/W2097460058","https://openalex.org/W2125723397","https://openalex.org/W2157688326","https://openalex.org/W2486095760","https://openalex.org/W6603748752","https://openalex.org/W6628750762"],"related_works":["https://openalex.org/W3180887190","https://openalex.org/W2320211095","https://openalex.org/W2308164565","https://openalex.org/W2062768126","https://openalex.org/W2059230675","https://openalex.org/W2376003823","https://openalex.org/W4402273478","https://openalex.org/W2594726310","https://openalex.org/W2355193834","https://openalex.org/W2731746886"],"abstract_inverted_index":{"An":[0],"active":[1],"area":[2],"of":[3,9,43,82,105],"current":[4],"research":[5],"is":[6,31,55,62,67],"the":[7,41],"discovery":[8,29],"novel":[10],"drugs":[11,18],"for":[12,14],"diseases":[13],"which":[15,66],"no":[16],"satisfactory":[17],"have":[19],"yet":[20],"been":[21],"found.":[22],"To":[23],"save":[24],"experimental":[25],"costs,":[26],"this":[27],"knowledge":[28],"task":[30],"assisted":[32],"greatly":[33],"by":[34,80,93],"computational":[35],"experiments":[36],"because":[37],"these":[38],"can":[39],"reduce":[40],"amount":[42],"actual":[44],"experimentation":[45],"required.":[46],"This":[47],"work":[48],"demonstrates":[49],"how":[50],"an":[51,95],"adaptive":[52],"neurofuzzy":[53],"computation":[54],"able":[56],"to":[57,99],"separate":[58],"molecular":[59],"data":[60],"that":[61,65],"bioactive":[63,106],"from":[64],"not":[68],"bioactive.":[69],"The":[70,88],"resulting":[71],"classification":[72],"rules":[73,89],"may":[74],"prove":[75],"useful":[76],"in":[77],"\"virtual":[78],"screening\"":[79],"means":[81],"runtime,":[83],"effectiveness,":[84],"and":[85],"explanatory":[86],"power.":[87],"are":[90],"further":[91],"improved":[92],"using":[94],"additional":[96],"evolutionary":[97],"strategy":[98],"offer":[100],"a":[101],"more":[102],"enriched":[103],"selection":[104],"molecules.":[107]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
