{"id":"https://openalex.org/W3083444526","doi":"https://doi.org/10.1109/cec48606.2020.9185572","title":"Inferring Gene Regulatory Network Models from Time-Series Data Using Metaheuristics","display_name":"Inferring Gene Regulatory Network Models from Time-Series Data Using Metaheuristics","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3083444526","doi":"https://doi.org/10.1109/cec48606.2020.9185572","mag":"3083444526"},"language":"en","primary_location":{"id":"doi:10.1109/cec48606.2020.9185572","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec48606.2020.9185572","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE Congress on Evolutionary Computation (CEC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000300845","display_name":"Jos\u00e9 Eduardo Henriques da Silva","orcid":"https://orcid.org/0000-0001-5997-0392"},"institutions":[{"id":"https://openalex.org/I101100930","display_name":"Universidade Federal de Juiz de Fora","ror":"https://ror.org/04yqw9c44","country_code":"BR","type":"education","lineage":["https://openalex.org/I101100930"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose Eduardo H. da Silva","raw_affiliation_strings":["Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil","institution_ids":["https://openalex.org/I101100930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040450922","display_name":"Heder S. Betnardino","orcid":null},"institutions":[{"id":"https://openalex.org/I101100930","display_name":"Universidade Federal de Juiz de Fora","ror":"https://ror.org/04yqw9c44","country_code":"BR","type":"education","lineage":["https://openalex.org/I101100930"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Heder S. Betnardino","raw_affiliation_strings":["Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil","institution_ids":["https://openalex.org/I101100930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052002490","display_name":"H\u00e9lio J. C. Barbosa","orcid":"https://orcid.org/0000-0001-5810-7554"},"institutions":[{"id":"https://openalex.org/I101100930","display_name":"Universidade Federal de Juiz de Fora","ror":"https://ror.org/04yqw9c44","country_code":"BR","type":"education","lineage":["https://openalex.org/I101100930"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Helio J.C. Barbosa","raw_affiliation_strings":["Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil","institution_ids":["https://openalex.org/I101100930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054304691","display_name":"Alex Borges Vieira","orcid":"https://orcid.org/0000-0003-0821-126X"},"institutions":[{"id":"https://openalex.org/I101100930","display_name":"Universidade Federal de Juiz de Fora","ror":"https://ror.org/04yqw9c44","country_code":"BR","type":"education","lineage":["https://openalex.org/I101100930"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alex B. Vieira","raw_affiliation_strings":["Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil","institution_ids":["https://openalex.org/I101100930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102264476","display_name":"Luciana C. D. Campos","orcid":null},"institutions":[{"id":"https://openalex.org/I101100930","display_name":"Universidade Federal de Juiz de Fora","ror":"https://ror.org/04yqw9c44","country_code":"BR","type":"education","lineage":["https://openalex.org/I101100930"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana C.D. Campos","raw_affiliation_strings":["Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil","institution_ids":["https://openalex.org/I101100930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038271939","display_name":"Itamar L. de Oliveira","orcid":null},"institutions":[{"id":"https://openalex.org/I101100930","display_name":"Universidade Federal de Juiz de Fora","ror":"https://ror.org/04yqw9c44","country_code":"BR","type":"education","lineage":["https://openalex.org/I101100930"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Itamar L. de Oliveira","raw_affiliation_strings":["Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil","institution_ids":["https://openalex.org/I101100930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3335,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.5763379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9868999719619751,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.7672883868217468},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.723842978477478},{"id":"https://openalex.org/keywords/ode","display_name":"Ode","score":0.64946049451828},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6468644142150879},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.58144211769104},{"id":"https://openalex.org/keywords/time-series","display_name":"Time series","score":0.5450383424758911},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5435081124305725},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.47976574301719666},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4659733772277832},{"id":"https://openalex.org/keywords/boolean-model","display_name":"Boolean model","score":0.4599844813346863},{"id":"https://openalex.org/keywords/series","display_name":"Series (stratigraphy)","score":0.41947031021118164},{"id":"https://openalex.org/keywords/dynamical-systems-theory","display_name":"Dynamical systems theory","score":0.41943126916885376},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.4189794361591339},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3955668807029724},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.380281925201416},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3603813648223877},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3078768253326416},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21191713213920593},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.20566755533218384},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.19870024919509888},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1391676962375641},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.120961993932724},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10244107246398926}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.7672883868217468},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.723842978477478},{"id":"https://openalex.org/C34862557","wikidata":"https://www.wikidata.org/wiki/Q178985","display_name":"Ode","level":2,"score":0.64946049451828},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6468644142150879},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.58144211769104},{"id":"https://openalex.org/C151406439","wikidata":"https://www.wikidata.org/wiki/Q186588","display_name":"Time series","level":2,"score":0.5450383424758911},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5435081124305725},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.47976574301719666},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4659733772277832},{"id":"https://openalex.org/C67499762","wikidata":"https://www.wikidata.org/wiki/Q4943358","display_name":"Boolean model","level":2,"score":0.4599844813346863},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.41947031021118164},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.41943126916885376},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4189794361591339},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3955668807029724},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.380281925201416},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3603813648223877},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3078768253326416},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21191713213920593},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.20566755533218384},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.19870024919509888},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1391676962375641},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.120961993932724},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10244107246398926},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cec48606.2020.9185572","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec48606.2020.9185572","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE Congress on Evolutionary Computation (CEC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W43207804","https://openalex.org/W106861343","https://openalex.org/W621499772","https://openalex.org/W1512383952","https://openalex.org/W1538006201","https://openalex.org/W1556539685","https://openalex.org/W1576660662","https://openalex.org/W1581536631","https://openalex.org/W1775913388","https://openalex.org/W2027631876","https://openalex.org/W2058221907","https://openalex.org/W2062029454","https://openalex.org/W2088907143","https://openalex.org/W2097144068","https://openalex.org/W2111932463","https://openalex.org/W2118809524","https://openalex.org/W2125886217","https://openalex.org/W2129737673","https://openalex.org/W2164822464","https://openalex.org/W2167437179","https://openalex.org/W2277210191","https://openalex.org/W2548209566","https://openalex.org/W2783151814","https://openalex.org/W2797163114","https://openalex.org/W3024161231","https://openalex.org/W4285719527","https://openalex.org/W4292333472","https://openalex.org/W6638085146","https://openalex.org/W6729373800","https://openalex.org/W6750377768"],"related_works":["https://openalex.org/W4385957992","https://openalex.org/W4229079080","https://openalex.org/W4206534706","https://openalex.org/W4385965371","https://openalex.org/W4386025632","https://openalex.org/W1992369898","https://openalex.org/W2005936873","https://openalex.org/W4290787198","https://openalex.org/W2140158840","https://openalex.org/W2094348357"],"abstract_inverted_index":{"The":[0,121,143],"inference":[1],"of":[2,29,45,57,89,101,114],"Gene":[3],"Regulatory":[4],"Networks":[5],"(GRNs)":[6],"from":[7,59],"gene":[8],"expression":[9],"data":[10,60,64],"is":[11,65,71,84,124],"a":[12,52,68,74,87,106],"hard":[13],"and":[14,22,26,39,93,116,139],"widely":[15],"addressed":[16],"scientific":[17],"challenge":[18],"with":[19,137],"potential":[20],"industrial":[21],"health-care":[23],"use.":[24],"Discrete":[25],"continuous":[27,103],"models":[28,56,144],"GRNs":[30,58],"are":[31,150],"often":[32],"used":[33],"(i)":[34,62],"to":[35,41,54,86,110,117,126,152],"understand":[36],"the":[37,43,46,63,80,99,102,112,132,147,154,158],"process,":[38],"(ii)":[40,67],"predict":[42],"values":[44],"relevant":[47],"variables.":[48,142],"Here,":[49],"we":[50,108],"propose":[51],"procedure":[53,149],"infer":[55],"where":[61],"binarized,":[66],"Boolean":[69,82],"model":[70,83],"created":[72,145],"using":[73],"Cartesian":[75],"Genetic":[76],"Programming":[77],"technique,":[78],"(iii)":[79],"obtained":[81],"converted":[85],"system":[88],"ordinary":[90],"differential":[91],"equations,":[92],"(iv)":[94],"an":[95],"Evolution":[96],"Strategy":[97],"defines":[98],"parameters":[100],"model.":[104],"As":[105],"result,":[107],"expect":[109],"reduce":[111],"effect":[113],"noise":[115],"improve":[118],"biological":[119],"interpretability.":[120],"proposed":[122,148],"method":[123],"applied":[125],"two":[127],"ODE":[128],"systems":[129],"that":[130],"describe":[131],"circadian":[133],"rhythm":[134],"network":[135],"dynamic,":[136],"5":[138],"10":[140],"state":[141],"by":[146],"able":[151],"reproduce":[153],"behavior":[155],"observed":[156],"in":[157],"original":[159],"data.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}