{"id":"https://openalex.org/W2150532767","doi":"https://doi.org/10.1109/cec.2012.6252997","title":"An analysis of the use of probabilistic modeling for synaptic connectivity prediction from genomic data","display_name":"An analysis of the use of probabilistic modeling for synaptic connectivity prediction from genomic data","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2150532767","doi":"https://doi.org/10.1109/cec.2012.6252997","mag":"2150532767"},"language":"en","primary_location":{"id":"doi:10.1109/cec.2012.6252997","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2012.6252997","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE Congress on Evolutionary Computation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034080501","display_name":"Roberto Santana","orcid":"https://orcid.org/0000-0002-1005-8535"},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Roberto Santana","raw_affiliation_strings":["Intelligent Systems Group, School of Computer Science, University of the Basque Country(UPV/EHU), Spain"],"affiliations":[{"raw_affiliation_string":"Intelligent Systems Group, School of Computer Science, University of the Basque Country(UPV/EHU), Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051966806","display_name":"Alexander Mendiburu","orcid":"https://orcid.org/0000-0002-7271-1931"},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alexander Mendiburu","raw_affiliation_strings":["Intelligent Systems Group, School of Computer Science, University of the Basque Country(UPV/EHU), Spain"],"affiliations":[{"raw_affiliation_string":"Intelligent Systems Group, School of Computer Science, University of the Basque Country(UPV/EHU), Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050500830","display_name":"Jos\u00e9 A. Lozano","orcid":"https://orcid.org/0000-0002-4683-8111"},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose A. Lozano","raw_affiliation_strings":["Intelligent Systems Group, School of Computer Science, University of the Basque Country(UPV/EHU), Spain"],"affiliations":[{"raw_affiliation_string":"Intelligent Systems Group, School of Computer Science, University of the Basque Country(UPV/EHU), Spain","institution_ids":["https://openalex.org/I169108374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034080501"],"corresponding_institution_ids":["https://openalex.org/I169108374"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11515553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9728999733924866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/predictability","display_name":"Predictability","score":0.7468752861022949},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6498091220855713},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.6124420762062073},{"id":"https://openalex.org/keywords/estimation-of-distribution-algorithm","display_name":"Estimation of distribution algorithm","score":0.5102639198303223},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.44238194823265076},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.4192127585411072},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38109901547431946},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3354814052581787},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19046863913536072}],"concepts":[{"id":"https://openalex.org/C197640229","wikidata":"https://www.wikidata.org/wiki/Q2534066","display_name":"Predictability","level":2,"score":0.7468752861022949},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6498091220855713},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.6124420762062073},{"id":"https://openalex.org/C162500139","wikidata":"https://www.wikidata.org/wiki/Q2835887","display_name":"Estimation of distribution algorithm","level":2,"score":0.5102639198303223},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.44238194823265076},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.4192127585411072},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38109901547431946},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3354814052581787},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19046863913536072},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cec.2012.6252997","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2012.6252997","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE Congress on Evolutionary Computation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W18216792","https://openalex.org/W54392149","https://openalex.org/W209170163","https://openalex.org/W1517815546","https://openalex.org/W1618644968","https://openalex.org/W1692958259","https://openalex.org/W1722282631","https://openalex.org/W1971353156","https://openalex.org/W1974519196","https://openalex.org/W1988316236","https://openalex.org/W1993673892","https://openalex.org/W2020892390","https://openalex.org/W2024060531","https://openalex.org/W2038450451","https://openalex.org/W2040092971","https://openalex.org/W2053484352","https://openalex.org/W2098090548","https://openalex.org/W2100850281","https://openalex.org/W2128151276","https://openalex.org/W2160938187","https://openalex.org/W2212848973","https://openalex.org/W2414365832","https://openalex.org/W3154803405","https://openalex.org/W4285719527","https://openalex.org/W6600754543","https://openalex.org/W6608497669","https://openalex.org/W6636641732","https://openalex.org/W6728121130"],"related_works":["https://openalex.org/W2726467123","https://openalex.org/W2064726690","https://openalex.org/W4252678288","https://openalex.org/W1607297154","https://openalex.org/W4210820789","https://openalex.org/W2913177154","https://openalex.org/W4310836149","https://openalex.org/W2056381839","https://openalex.org/W1548248515","https://openalex.org/W1935138604"],"abstract_inverted_index":{"The":[0,35],"identification":[1],"of":[2,24,28,48,64,69,113,132,135],"the":[3,22,26,45,54,62,85,101,130],"specific":[4],"genes":[5],"that":[6,84,94,119],"influence":[7,27],"particular":[8],"phenotypes":[9],"is":[10,37,58],"a":[11],"common":[12],"problem":[13,23,42],"in":[14,32,43],"genetic":[15],"studies.":[16],"In":[17],"this":[18],"paper":[19],"we":[20],"address":[21],"determining":[25],"gene":[29,49,92,108],"joint":[30],"expression":[31],"synapse":[33,98],"predictability.":[34,99],"question":[36],"posed":[38],"as":[39],"an":[40,96],"optimization":[41,120],"which":[44],"conditional":[46],"entropy":[47],"subsets":[50],"with":[51,110],"respect":[52],"to":[53,90],"synaptic":[55,80],"connectivity":[56],"phenotype":[57],"minimized.":[59],"We":[60,82],"investigate":[61],"use":[63],"single-":[65],"and":[66,72],"multi-objective":[67,102],"estimation":[68,134],"distribution":[70,136],"algorithms":[71,87],"focus":[73],"on":[74,123],"real":[75],"data":[76],"from":[77],"C.":[78],"elegans":[79],"connectivity.":[81],"show":[83],"introduced":[86],"are":[88],"able":[89],"compute":[91],"sets":[93,109],"allow":[95],"accurate":[97],"However,":[100],"approach":[103],"can":[104],"simultaneously":[105],"search":[106],"for":[107,129],"different":[111],"number":[112],"genes.":[114],"Our":[115],"results":[116],"also":[117],"indicate":[118],"problems":[121],"defined":[122],"constrained":[124],"binary":[125],"spaces":[126],"remain":[127],"challenging":[128],"conception":[131],"competitive":[133],"algorithm.":[137]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
