{"id":"https://openalex.org/W2171409513","doi":"https://doi.org/10.1109/cec.2008.4631120","title":"An Estimation of Distribution Algorithm for Motif Discovery","display_name":"An Estimation of Distribution Algorithm for Motif Discovery","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2171409513","doi":"https://doi.org/10.1109/cec.2008.4631120","mag":"2171409513"},"language":"en","primary_location":{"id":"doi:10.1109/cec.2008.4631120","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2008.4631120","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 IEEE Congress on Evolutionary Computation (IEEE World Congress on Computational Intelligence)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100438781","display_name":"Gang Li","orcid":"https://orcid.org/0000-0003-3203-8567"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gang Li","raw_affiliation_strings":["Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073652431","display_name":"Tak\u2010Ming Chan","orcid":"https://orcid.org/0000-0003-0478-2305"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tak-Ming Chan","raw_affiliation_strings":["Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113675788","display_name":"Kwong-Sak Leung","orcid":null},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kwong-Sak Leung","raw_affiliation_strings":["Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109898714","display_name":"Kin-Hong Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kin-Hong Lee","raw_affiliation_strings":["Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Chinese University of Hong Kong, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100438781"],"corresponding_institution_ids":["https://openalex.org/I177725633"],"apc_list":null,"apc_paid":null,"fwci":0.1347,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55516961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"262","issue":null,"first_page":"2411","last_page":"2418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motif","display_name":"Motif (music)","score":0.803646445274353},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.5156618356704712},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4764414429664612},{"id":"https://openalex.org/keywords/sequence-motif","display_name":"Sequence motif","score":0.46965447068214417},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4669545590877533},{"id":"https://openalex.org/keywords/fitness-function","display_name":"Fitness function","score":0.4479863941669464},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3575804829597473},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3364223837852478},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29993921518325806},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16380971670150757},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14976170659065247},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10261550545692444},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.1019323468208313},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.08814460039138794}],"concepts":[{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.803646445274353},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.5156618356704712},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4764414429664612},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.46965447068214417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4669545590877533},{"id":"https://openalex.org/C176066374","wikidata":"https://www.wikidata.org/wiki/Q629118","display_name":"Fitness function","level":3,"score":0.4479863941669464},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3575804829597473},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3364223837852478},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29993921518325806},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16380971670150757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14976170659065247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10261550545692444},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.1019323468208313},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08814460039138794},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cec.2008.4631120","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2008.4631120","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008 IEEE Congress on Evolutionary Computation (IEEE World Congress on Computational Intelligence)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1486659038","https://openalex.org/W1540706608","https://openalex.org/W1580213736","https://openalex.org/W1592870802","https://openalex.org/W1965267927","https://openalex.org/W1989080074","https://openalex.org/W1992748956","https://openalex.org/W1994755936","https://openalex.org/W1998300401","https://openalex.org/W2021809202","https://openalex.org/W2028904582","https://openalex.org/W2049114051","https://openalex.org/W2053743126","https://openalex.org/W2065715761","https://openalex.org/W2077013196","https://openalex.org/W2099180682","https://openalex.org/W2101025813","https://openalex.org/W2105355645","https://openalex.org/W2111359483","https://openalex.org/W2113903955","https://openalex.org/W2119622140","https://openalex.org/W2135729552","https://openalex.org/W2149312834","https://openalex.org/W2151638714","https://openalex.org/W2155976638","https://openalex.org/W2156040591","https://openalex.org/W2158561153","https://openalex.org/W2158962723","https://openalex.org/W2159831212","https://openalex.org/W2166429927","https://openalex.org/W4249255000","https://openalex.org/W6628970866","https://openalex.org/W6634719314","https://openalex.org/W6635200387"],"related_works":["https://openalex.org/W3170299350","https://openalex.org/W2073661767","https://openalex.org/W2143211236","https://openalex.org/W2380185347","https://openalex.org/W2370034659","https://openalex.org/W2159636084","https://openalex.org/W2610941444","https://openalex.org/W2117168988","https://openalex.org/W2154430121","https://openalex.org/W2103777723"],"abstract_inverted_index":{"The":[0,25,188],"problem":[1,32],"of":[2,22,40,61,64,76,91,94,100,108,127,144,155],"Transcription":[3],"Factor":[4],"Binding":[5],"Sites":[6],"identification":[7],"or":[8,197],"motif":[9,15,65,77,95,109,128,156,164,183],"discovery":[10],"is":[11,33,98,118,130,150,178,194],"to":[12,51,56,71,87,180,196],"identify":[13],"the":[14,19,31,53,58,80,89,92,102,106,121,134,137,142,147,153,175,186,204],"binding":[16],"sites":[17],"in":[18,79,208],"cis-regulatory":[20],"regions":[21],"DNA":[23],"sequences.":[24,81],"biological":[26],"experiments":[27,189],"are":[28],"expensive":[29],"and":[30,201],"NP-hard":[34],"computationally.":[35],"We":[36,47],"have":[37,190],"proposed":[38],"Estimation":[39],"Distribution":[41],"Algorithm":[42],"for":[43],"Motif":[44],"Discovery":[45],"(EDAMD).":[46],"use":[48],"Bayesian":[49],"analysis":[50],"derive":[52],"fitness":[54,176],"function":[55,177],"measure":[57],"posterior":[59],"probability":[60],"a":[62,73,84,112,124,145,162,167,169],"set":[63,126],"instances,":[66,96],"which":[67,97],"can":[68],"be":[69],"used":[70,179],"handle":[72],"variable":[74],"number":[75],"instances":[78,129,184],"EDAMD":[82,193],"adopts":[83],"Gaussian":[85,122,148],"distribution":[86,90,149],"model":[88],"sets":[93,154],"capable":[99],"capturing":[101],"bivariate":[103],"correlation":[104],"among":[105],"positions":[107],"instances.":[110,157],"When":[111],"new":[113,125],"Position":[114],"Frequency":[115],"Matrix":[116],"(PFM)":[117],"generated":[119],"from":[120],"distribution,":[123],"identified":[131],"based":[132,173],"on":[133,166,174,203],"PFM":[135],"via":[136],"Greedy":[138,159],"Refinement":[139,160],"operation.":[140],"At":[141],"end":[143],"generation,":[146],"updated":[151],"with":[152],"Since":[158],"assumes":[161],"single":[163],"instance":[165],"sequence,":[168],"Post":[170],"Processing":[171],"operation":[172],"find":[181],"more":[182],"after":[185],"evolution.":[187],"verified":[191],"that":[192],"comparable":[195],"better":[198],"than":[199],"GAME":[200],"GALF":[202],"real":[205],"problems":[206],"tested":[207],"this":[209],"paper.":[210]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}