{"id":"https://openalex.org/W1848445467","doi":"https://doi.org/10.1109/cec.2002.1006251","title":"Global optimization of protein 3-dimensional structures in NMR by a genetic algorithm","display_name":"Global optimization of protein 3-dimensional structures in NMR by a genetic algorithm","publication_year":2003,"publication_date":"2003-06-25","ids":{"openalex":"https://openalex.org/W1848445467","doi":"https://doi.org/10.1109/cec.2002.1006251","mag":"1848445467"},"language":"en","primary_location":{"id":"doi:10.1109/cec.2002.1006251","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2002.1006251","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2002 Congress on Evolutionary Computation. CEC'02 (Cat. No.02TH8600)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101985444","display_name":"Iwao Ono","orcid":"https://orcid.org/0000-0001-8361-1285"},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Ono","raw_affiliation_strings":["Faculty of Engineering, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077369032","display_name":"HIROSHI FUJIKI","orcid":null},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Fujiki","raw_affiliation_strings":["Faculty of Engineering, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028571618","display_name":"M. Ootsuka","orcid":null},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ootsuka","raw_affiliation_strings":["Faculty of Engineering, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001521486","display_name":"Nobutaka Nakashima","orcid":"https://orcid.org/0000-0002-5836-9148"},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Nakashima","raw_affiliation_strings":["Faculty of Engineering, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057392144","display_name":"Norihiko Ono","orcid":null},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Ono","raw_affiliation_strings":["Faculty of Engineering, University of Tokushima, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, University of Tokushima, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063608760","display_name":"Shin\u2010ichi Tate","orcid":"https://orcid.org/0000-0002-5556-7712"},"institutions":[{"id":"https://openalex.org/I177738480","display_name":"Japan Advanced Institute of Science and Technology","ror":"https://ror.org/03frj4r98","country_code":"JP","type":"education","lineage":["https://openalex.org/I177738480"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S.-I. Tate","raw_affiliation_strings":["Center of New Materials, Japan Advanced Institute of Science and Technology, Tatsunokuchi, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of New Materials, Japan Advanced Institute of Science and Technology, Tatsunokuchi, Ishikawa, Japan","institution_ids":["https://openalex.org/I177738480"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6874,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.65990578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"1","issue":null,"first_page":"303","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-overhauser-effect","display_name":"Nuclear Overhauser effect","score":0.6502065658569336},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance-spectroscopy","display_name":"Nuclear magnetic resonance spectroscopy","score":0.6153740882873535},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5993887186050415},{"id":"https://openalex.org/keywords/substructure","display_name":"Substructure","score":0.5601398944854736},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4974539577960968},{"id":"https://openalex.org/keywords/two-dimensional-nuclear-magnetic-resonance-spectroscopy","display_name":"Two-dimensional nuclear magnetic resonance spectroscopy","score":0.46940338611602783},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45278260111808777},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.43900173902511597},{"id":"https://openalex.org/keywords/resolution","display_name":"Resolution (logic)","score":0.4284302592277527},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.42320960760116577},{"id":"https://openalex.org/keywords/spectroscopy","display_name":"Spectroscopy","score":0.42145949602127075},{"id":"https://openalex.org/keywords/molecular-biophysics","display_name":"Molecular biophysics","score":0.4145648181438446},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.410768061876297},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.3997393250465393},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3784730136394501},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.283551961183548},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23595064878463745},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.15919968485832214},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.14324888586997986},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12015187740325928}],"concepts":[{"id":"https://openalex.org/C119851462","wikidata":"https://www.wikidata.org/wiki/Q901095","display_name":"Nuclear Overhauser effect","level":3,"score":0.6502065658569336},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.6153740882873535},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5993887186050415},{"id":"https://openalex.org/C99679407","wikidata":"https://www.wikidata.org/wiki/Q56761637","display_name":"Substructure","level":2,"score":0.5601398944854736},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4974539577960968},{"id":"https://openalex.org/C19549132","wikidata":"https://www.wikidata.org/wiki/Q11141463","display_name":"Two-dimensional nuclear magnetic resonance spectroscopy","level":2,"score":0.46940338611602783},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45278260111808777},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.43900173902511597},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4284302592277527},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.42320960760116577},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.42145949602127075},{"id":"https://openalex.org/C70636015","wikidata":"https://www.wikidata.org/wiki/Q4300350","display_name":"Molecular biophysics","level":2,"score":0.4145648181438446},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.410768061876297},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3997393250465393},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3784730136394501},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.283551961183548},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23595064878463745},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.15919968485832214},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14324888586997986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12015187740325928},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cec.2002.1006251","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2002.1006251","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2002 Congress on Evolutionary Computation. CEC'02 (Cat. No.02TH8600)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W100223930","https://openalex.org/W613193799","https://openalex.org/W656827624","https://openalex.org/W1491642680","https://openalex.org/W1964072615","https://openalex.org/W2016289448","https://openalex.org/W2130490129","https://openalex.org/W2166923082","https://openalex.org/W2949250147"],"related_works":["https://openalex.org/W3150982967","https://openalex.org/W1973265599","https://openalex.org/W2032598710","https://openalex.org/W2090246676","https://openalex.org/W4250964391","https://openalex.org/W2091127895","https://openalex.org/W2581966282","https://openalex.org/W1980715645","https://openalex.org/W2026480123","https://openalex.org/W4242446301"],"abstract_inverted_index":{"Protein":[0],"three-dimensional":[1,29],"structure":[2,95],"determination":[3],"is":[4,19,49,101],"one":[5,20],"of":[6,21,26,31,76,96,106],"the":[7,22,28,50,94],"most":[8,51],"important":[9],"problems":[10],"in":[11],"molecular":[12],"biology.":[13],"Nuclear":[14],"magnetic":[15],"resonance":[16],"(NMR)":[17],"spectroscopy":[18],"promising":[23],"techniques":[24],"capable":[25],"determining":[27,37,93],"structures":[30,39],"proteins":[32],"at":[33],"atomic":[34],"resolution.":[35],"In":[36,66],"protein":[38,110],"using":[40],"NMR":[41],"spectroscopy,":[42],"nuclear":[43],"Overhauser":[44],"effect":[45],"(NOE)":[46],"signal":[47,60],"assignment":[48,61,74],"laborious":[52],"and":[53,85,108],"time-consuming":[54],"process.":[55],"Attempts":[56],"to":[57,92],"automate":[58],"NOE":[59,77],"have":[62],"failed":[63],"so":[64],"far.":[65],"this":[67],"paper,":[68],"we":[69],"propose":[70],"a":[71,81,102,109],"new":[72],"automatic":[73],"method":[75],"signals":[78],"based":[79],"on":[80],"real-coded":[82],"genetic":[83],"algorithm":[84],"examine":[86],"its":[87],"effectiveness":[88],"by":[89],"applying":[90],"it":[91],"an":[97],"/spl":[98],"alpha/-helix,":[99],"which":[100],"well-known":[103],"common":[104],"substructure":[105],"proteins,":[107],"called":[111],"HMG2B.":[112]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
