{"id":"https://openalex.org/W7123365686","doi":"https://doi.org/10.1109/cdc57313.2025.11312720","title":"Guaranteed multistability in a microRNA-based genetic network by formal methods","display_name":"Guaranteed multistability in a microRNA-based genetic network by formal methods","publication_year":2025,"publication_date":"2025-12-09","ids":{"openalex":"https://openalex.org/W7123365686","doi":"https://doi.org/10.1109/cdc57313.2025.11312720"},"language":null,"primary_location":{"id":"doi:10.1109/cdc57313.2025.11312720","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc57313.2025.11312720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 64th Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122856974","display_name":"Nicholas Nolan","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Nolan","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034213602","display_name":"Emma L. Peterman","orcid":"https://orcid.org/0000-0001-7402-576X"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma L. Peterman","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071456508","display_name":"Kate E. Galloway","orcid":"https://orcid.org/0000-0001-7416-3193"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate E. Galloway","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068753451","display_name":"Eduardo D. Sontag","orcid":"https://orcid.org/0000-0001-8020-5783"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo D. Sontag","raw_affiliation_strings":["Northeastern University,Boston,MA,USA,02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University,Boston,MA,USA,02115","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036095256","display_name":"Domitilla Del Vecchio","orcid":"https://orcid.org/0000-0001-6472-8576"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domitilla Del Vecchio","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59206044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3043","last_page":"3048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7936000227928162,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7936000227928162,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.06650000065565109,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multistability","display_name":"Multistability","score":0.8858000040054321},{"id":"https://openalex.org/keywords/payload","display_name":"Payload (computing)","score":0.7846999764442444},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5206999778747559},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5188000202178955},{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.48730000853538513},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.4602000117301941}],"concepts":[{"id":"https://openalex.org/C2776966350","wikidata":"https://www.wikidata.org/wiki/Q6935096","display_name":"Multistability","level":3,"score":0.8858000040054321},{"id":"https://openalex.org/C134066672","wikidata":"https://www.wikidata.org/wiki/Q1424639","display_name":"Payload (computing)","level":3,"score":0.7846999764442444},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6789000034332275},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5206999778747559},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5188000202178955},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.48730000853538513},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.4602000117301941},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4090000092983246},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C75606506","wikidata":"https://www.wikidata.org/wiki/Q1049183","display_name":"Formal methods","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.29980000853538513},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.2815999984741211},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.27630001306533813},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2619999945163727}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc57313.2025.11312720","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc57313.2025.11312720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 64th Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,113,119],"genetic":[3,41,102,121],"memory":[4,42],"devices":[5,43],"in":[6,57,116],"synthetic":[7],"biology":[8],"is":[9,24],"a":[10,30,62,100],"challenging":[11],"process":[12],"that":[13,78,94,105],"requires":[14],"extensive":[15],"analysis":[16],"and":[17,84,109],"characterization.":[18],"In":[19],"mammalian":[20],"systems,":[21],"this":[22,58],"complexity":[23],"compounded":[25],"by":[26,53],"the":[27,38,69,79,111,117],"need":[28],"for":[29,34,72],"small":[31],"DNA":[32],"payload":[33,70],"efficient":[35,74],"delivery":[36],"into":[37],"cell.":[39],"Previous":[40],"have":[44],"relied":[45],"exclusively":[46],"on":[47,91],"protein-based":[48],"regulation,":[49],"which":[50,66],"are":[51],"limited":[52],"their":[54],"large":[55],"size;":[56],"paper,":[59],"we":[60],"propose":[61],"microRNA-based":[63],"multistable":[64],"network,":[65],"effectively":[67],"halves":[68],"size":[71],"more":[73],"delivery.":[75],"We":[76],"demonstrate":[77,110],"system":[80],"can":[81,106],"be":[82],"multistable,":[83],"use":[85,112],"formal":[86,114],"methods":[87,115],"to":[88],"characterize":[89],"constraints":[90],"design":[92,118],"parameters":[93],"guarantee":[95],"multistability.":[96],"Our":[97],"results":[98],"provide":[99],"new":[101],"network":[103,122],"topology":[104],"achieve":[107],"multistability":[108],"sophisticated":[120],"architectures":[123],"against":[124],"non-convex":[125],"top-level":[126],"specifications.":[127]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2026-01-14T00:00:00"}
