{"id":"https://openalex.org/W7123352980","doi":"https://doi.org/10.1109/cdc57313.2025.11311975","title":"Automatic Feedback Control for Resource-Aware Characterisation of Genetic Circuits","display_name":"Automatic Feedback Control for Resource-Aware Characterisation of Genetic Circuits","publication_year":2025,"publication_date":"2025-12-09","ids":{"openalex":"https://openalex.org/W7123352980","doi":"https://doi.org/10.1109/cdc57313.2025.11311975"},"language":null,"primary_location":{"id":"doi:10.1109/cdc57313.2025.11311975","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc57313.2025.11311975","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 64th Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088394841","display_name":"Kirill Sechkar","orcid":"https://orcid.org/0000-0003-2300-8278"},"institutions":[{"id":"https://openalex.org/I4210146410","display_name":"Science Oxford","ror":"https://ror.org/04j8yhy50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210146410"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kirill Sechkar","raw_affiliation_strings":["University of Oxford,Department of Engineering Science,Oxford,UK,OX1 3PJ"],"affiliations":[{"raw_affiliation_string":"University of Oxford,Department of Engineering Science,Oxford,UK,OX1 3PJ","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210146410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034003551","display_name":"Harrison Steel","orcid":"https://orcid.org/0000-0002-9625-4755"},"institutions":[{"id":"https://openalex.org/I4210146410","display_name":"Science Oxford","ror":"https://ror.org/04j8yhy50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210146410"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harrison Steel","raw_affiliation_strings":["University of Oxford,Department of Engineering Science,Oxford,UK,OX1 3PJ"],"affiliations":[{"raw_affiliation_string":"University of Oxford,Department of Engineering Science,Oxford,UK,OX1 3PJ","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210146410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088394841"],"corresponding_institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210146410"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64549306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1913","last_page":"1918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6065999865531921,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6065999865531921,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.28060001134872437,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/predictability","display_name":"Predictability","score":0.7430999875068665},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4837000072002411},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.4717000126838684},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.46889999508857727},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.46070000529289246},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.41110000014305115},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.36730000376701355},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.3549000024795532},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.3513999879360199}],"concepts":[{"id":"https://openalex.org/C197640229","wikidata":"https://www.wikidata.org/wiki/Q2534066","display_name":"Predictability","level":2,"score":0.7430999875068665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6575999855995178},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4837000072002411},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.4717000126838684},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.46889999508857727},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.41110000014305115},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.3224000036716461},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.3215999901294708},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.29120001196861267},{"id":"https://openalex.org/C155386361","wikidata":"https://www.wikidata.org/wiki/Q1649571","display_name":"Process control","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.2808000147342682},{"id":"https://openalex.org/C110332635","wikidata":"https://www.wikidata.org/wiki/Q629498","display_name":"Genetic programming","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.26249998807907104},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc57313.2025.11311975","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc57313.2025.11311975","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 64th Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1963204303","https://openalex.org/W2102749992","https://openalex.org/W2153501719","https://openalex.org/W2767587403","https://openalex.org/W2768425954","https://openalex.org/W2952545994","https://openalex.org/W2967875832","https://openalex.org/W3087683406","https://openalex.org/W3127085701","https://openalex.org/W3139296770","https://openalex.org/W3209310296","https://openalex.org/W3211806374","https://openalex.org/W4283278020","https://openalex.org/W4389083277","https://openalex.org/W4389214983","https://openalex.org/W4392367712","https://openalex.org/W4402224731","https://openalex.org/W4407358258"],"related_works":[],"abstract_inverted_index":{"Many":[0],"applications":[1],"of":[2,12,43,152,187,206,217,237],"engineered":[3],"cells":[4],"are":[5,22],"enabled":[6],"by":[7,24,134,170],"genetic":[8,153,197,208,238],"circuits":[9,21,239],"\u2013":[10],"networks":[11],"genes":[13,33],"regulating":[14],"each":[15],"other":[16,224],"to":[17,105,119,194,231,234],"process":[18],"signals.":[19],"Complex":[20],"built":[23],"combining":[25],"standardised":[26,241],"modular":[27],"components":[28,54],"with":[29,175,184,210,222],"different":[30,185],"functions.":[31],"Nonetheless,":[32],"in":[34,62,97],"a":[35,67,135,144,195,207],"cell":[36,178],"compete":[37],"for":[38,80,148],"the":[39,150,158,235],"same":[40],"limited":[41,112],"pool":[42],"cellular":[44],"resources,":[45],"causing":[46],"unintended":[47],"interactions":[48,75],"that":[49,129],"violate":[50],"modularity.":[51],"Thus,":[52],"circuit":[53,225],"behave":[55],"differently":[56],"when":[57,60,220],"combined":[58,221],"versus":[59],"observed":[61],"isolation,":[63],"which":[64,98],"can":[65],"compromise":[66],"biotechnology\u2019s":[68],"predictability":[69,233],"and":[70,166],"reliability.":[71],"To":[72],"forecast":[73],"steady-state":[74],"between":[76],"modules,":[77],"experimental":[78,109],"protocols":[79],"characterising":[81,149],"their":[82],"resource":[83],"competition":[84],"properties":[85],"have":[86,111],"been":[87],"proposed.":[88],"However,":[89],"they":[90,116],"rely":[91],"on":[92,157],"open-loop":[93],"batch":[94],"culture":[95],"techniques":[96],"dynamic":[99],"control":[100,213],"signals":[101],"cannot":[102],"be":[103,132],"applied":[104],"cells.":[106],"Consequently,":[107],"these":[108],"methods":[110],"predictive":[113],"power,":[114],"as":[115,126],"may":[117],"fail":[118],"capture":[120],"all":[121],"possible":[122],"steady":[123,168],"states,":[124],"such":[125],"repelling":[127],"equilibria":[128],"would":[130],"not":[131],"approached":[133],"system":[136],"without":[137],"external":[138],"forcing.":[139],"In":[140],"contrast,":[141],"we":[142,189],"propose":[143],"novel,":[145],"comprehensive":[146],"protocol":[147,229],"resource-dependence":[151],"modules\u2019":[154],"performance.":[155],"Based":[156],"control-based":[159],"continuation":[160],"technique,":[161],"it":[162],"captures":[163],"both":[164],"stable":[165],"unstable":[167],"states":[169],"applying":[171,191],"stabilising":[172],"cybergenetic":[173],"feedback":[174,212],"an":[176],"automated":[177],"culturing":[179],"platform.":[180],"Using":[181],"several":[182],"models":[183],"degrees":[186],"complexity,":[188],"simulate":[190],"our":[192,228],"pipeline":[193],"self-activating":[196],"switch.":[198],"This":[199],"case":[200],"study":[201],"illustrates":[202],"how":[203],"informative":[204],"characterisation":[205],"module":[209],"automatic":[211],"enables":[214],"reliable":[215],"forecasting":[216],"its":[218],"performance":[219],"any":[223],"component.":[226],"Hence,":[227],"promises":[230],"restore":[232],"design":[236],"from":[240],"components.":[242]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2026-01-14T00:00:00"}