{"id":"https://openalex.org/W4407949436","doi":"https://doi.org/10.1109/cdc56724.2024.10886081","title":"Guaranteeing System-level Properties in Genetic Circuits Subject to Context Effects","display_name":"Guaranteeing System-level Properties in Genetic Circuits Subject to Context Effects","publication_year":2024,"publication_date":"2024-12-16","ids":{"openalex":"https://openalex.org/W4407949436","doi":"https://doi.org/10.1109/cdc56724.2024.10886081"},"language":"en","primary_location":{"id":"doi:10.1109/cdc56724.2024.10886081","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc56724.2024.10886081","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 63rd Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.mit.edu/bitstream/1721.1/159843/2/CDC24_InigoFinal.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032980399","display_name":"Inigo Incer","orcid":"https://orcid.org/0000-0001-7933-692X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inigo Incer","raw_affiliation_strings":["University of Michigan,Ann Arbor,MI,USA,48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan,Ann Arbor,MI,USA,48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084734938","display_name":"Ayush Pandey","orcid":"https://orcid.org/0000-0003-3590-4459"},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayush Pandey","raw_affiliation_strings":["University of California,Merced,CA,USA,95343"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California,Merced,CA,USA,95343","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020638635","display_name":"Nicholas Nolan","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Nolan","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034213602","display_name":"Emma L. Peterman","orcid":"https://orcid.org/0000-0001-7402-576X"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma L. Peterman","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071456508","display_name":"Kate E. Galloway","orcid":"https://orcid.org/0000-0001-7416-3193"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate E. Galloway","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068753451","display_name":"Eduardo D. Sontag","orcid":"https://orcid.org/0000-0001-8020-5783"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo D. Sontag","raw_affiliation_strings":["E.D. Sontag is with Northeastern University,Boston,MA,USA,02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"E.D. Sontag is with Northeastern University,Boston,MA,USA,02115","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036095256","display_name":"Domitilla Del Vecchio","orcid":"https://orcid.org/0000-0001-6472-8576"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domitilla Del Vecchio","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,USA,02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,USA,02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21206477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"5558","last_page":"5565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9133999943733215,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6332257986068726},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6294407844543457},{"id":"https://openalex.org/keywords/subject","display_name":"Subject (documents)","score":0.520975649356842},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.46235665678977966},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1353934407234192},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.10973817110061646},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.0808936357498169}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6332257986068726},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6294407844543457},{"id":"https://openalex.org/C2777855551","wikidata":"https://www.wikidata.org/wiki/Q12310021","display_name":"Subject (documents)","level":2,"score":0.520975649356842},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.46235665678977966},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1353934407234192},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.10973817110061646},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0808936357498169},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cdc56724.2024.10886081","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc56724.2024.10886081","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 63rd Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/159843","is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/159843","pdf_url":"https://dspace.mit.edu/bitstream/1721.1/159843/2/CDC24_InigoFinal.pdf","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MIT website","raw_type":"http://purl.org/eprint/type/ConferencePaper"}],"best_oa_location":{"id":"pmh:oai:dspace.mit.edu:1721.1/159843","is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/159843","pdf_url":"https://dspace.mit.edu/bitstream/1721.1/159843/2/CDC24_InigoFinal.pdf","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MIT website","raw_type":"http://purl.org/eprint/type/ConferencePaper"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407949436.pdf","grobid_xml":"https://content.openalex.org/works/W4407949436.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1963204303","https://openalex.org/W1966645118","https://openalex.org/W2014425442","https://openalex.org/W2029991507","https://openalex.org/W2047360542","https://openalex.org/W2134759932","https://openalex.org/W2186962916","https://openalex.org/W2346028445","https://openalex.org/W2569612626","https://openalex.org/W2617511364","https://openalex.org/W2761578112","https://openalex.org/W2887357191","https://openalex.org/W2900498998","https://openalex.org/W2949263858","https://openalex.org/W2951697204","https://openalex.org/W2952545994","https://openalex.org/W2955245896","https://openalex.org/W2994590122","https://openalex.org/W3010430816","https://openalex.org/W3087683406","https://openalex.org/W3103811267","https://openalex.org/W3211507591","https://openalex.org/W4225678461","https://openalex.org/W4236366502","https://openalex.org/W4283374679","https://openalex.org/W4291954805","https://openalex.org/W4309236195","https://openalex.org/W4389127898","https://openalex.org/W6852479582"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4388258507","https://openalex.org/W2392013855","https://openalex.org/W4318064328","https://openalex.org/W2357926602","https://openalex.org/W3200517220","https://openalex.org/W2374569605","https://openalex.org/W2386062718"],"abstract_inverted_index":{"The":[0],"identification":[1],"of":[2,49,74,90,95,101,108,114],"constraints":[3],"on":[4,70,78,87],"system":[5,12],"parameters":[6],"that":[7,10],"will":[8],"ensure":[9],"a":[11,17,47],"achieves":[13],"desired":[14],"requirements":[15],"remains":[16],"challenge":[18],"in":[19,33,92],"synthetic":[20],"biology,":[21],"where":[22],"components":[23],"unintentionally":[24],"affect":[25],"one":[26],"another":[27],"by":[28],"perturbing":[29],"the":[30,67,71,75,79,88,96],"cellular":[31],"environment":[32],"which":[34],"they":[35],"operate.":[36],"This":[37],"paper":[38],"shows":[39],"how":[40,64],"to":[41,58,65,104],"solve":[42,66],"this":[43,102],"problem":[44,68],"optimally":[45],"for":[46,54],"class":[48],"input/output":[50,72],"system-level":[51,106],"specifications,":[52],"and":[53,77,110,113],"unintended":[55,80],"interactions":[56],"due":[57],"resource":[59],"sharing.":[60],"Specifically,":[61],"we":[62],"show":[63],"based":[69,86],"properties":[73,94],"subsystems":[76],"interaction":[81],"map.":[82],"Our":[83],"approach":[84],"is":[85],"elimination":[89],"quantifiers":[91],"monotone":[93],"system.":[97],"We":[98],"illustrate":[99],"applications":[100],"methodology":[103],"guaranteeing":[105],"performance":[107],"multiplexed":[109],"sequential":[111],"biosensing":[112],"bistable":[115],"genetic":[116],"circuits.":[117]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
