{"id":"https://openalex.org/W4407987967","doi":"https://doi.org/10.1109/cdc56724.2024.10886005","title":"Comparison of closed loop control strategies for the activation of genetic switches","display_name":"Comparison of closed loop control strategies for the activation of genetic switches","publication_year":2024,"publication_date":"2024-12-16","ids":{"openalex":"https://openalex.org/W4407987967","doi":"https://doi.org/10.1109/cdc56724.2024.10886005"},"language":"en","primary_location":{"id":"doi:10.1109/cdc56724.2024.10886005","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc56724.2024.10886005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 63rd Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067923983","display_name":"Alexander P. S. Darlington","orcid":"https://orcid.org/0000-0001-8025-6329"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander P.S. Darlington","raw_affiliation_strings":["University of Warwick,Warwick Integrative Synthetic Biology Centre School of Engineering,Coventry,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Warwick,Warwick Integrative Synthetic Biology Centre School of Engineering,Coventry,UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039986402","display_name":"Ahmad A. Mannan","orcid":"https://orcid.org/0000-0001-7628-8416"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmad A. Mannan","raw_affiliation_strings":["Imperial College London,Department of Bioengineering,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London,Department of Bioengineering,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["University of Warwick,Warwick Integrative Synthetic Biology Centre School of Engineering,Coventry,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Warwick,Warwick Integrative Synthetic Biology Centre School of Engineering,Coventry,UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34515296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"7798","last_page":"7803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8934000134468079,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8934000134468079,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.5458862781524658},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.5117018222808838},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48892083764076233},{"id":"https://openalex.org/keywords/loop","display_name":"Loop (graph theory)","score":0.483573853969574},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4773195683956146},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.20969229936599731},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.14401617646217346},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1428672969341278},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1220967173576355}],"concepts":[{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.5458862781524658},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.5117018222808838},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48892083764076233},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.483573853969574},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4773195683956146},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.20969229936599731},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14401617646217346},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1428672969341278},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1220967173576355},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc56724.2024.10886005","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc56724.2024.10886005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE 63rd Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320005","display_name":"Royal Academy of Engineering","ror":"https://ror.org/0526snb40"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2076477598","https://openalex.org/W2951697204","https://openalex.org/W2952545994","https://openalex.org/W2992836595","https://openalex.org/W3084584220","https://openalex.org/W3140707518","https://openalex.org/W3169670052","https://openalex.org/W4309974596","https://openalex.org/W4390048003","https://openalex.org/W4391020079"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W24774503","https://openalex.org/W2390279801","https://openalex.org/W2322335058","https://openalex.org/W2259382430","https://openalex.org/W2397460850","https://openalex.org/W4322484979","https://openalex.org/W2612895087"],"abstract_inverted_index":{"The":[0],"performance":[1],"of":[2,28,42,61,79],"biomanufacturing":[3],"systems":[4],"can":[5],"be":[6],"improved":[7],"by":[8],"incorporating":[9],"inducible":[10],"synthetic":[11],"gene":[12],"circuits":[13],"which":[14,38,55],"\u2018switch\u2019":[15],"the":[16,25,59],"microbial":[17,62],"cell":[18,48],"factories":[19],"from":[20],"growth":[21,63],"to":[22],"production":[23],"upon":[24],"manual":[26],"addition":[27],"a":[29,43,51,73],"small":[30],"molecule":[31],"activator.":[32],"Here,":[33],"we":[34,67],"consider":[35],"feedback":[36,71],"strategies":[37],"enable":[39],"autonomous":[40,77],"activation":[41,78],"genetic":[44,80],"circuit":[45],"based":[46],"on":[47],"state.":[49],"Using":[50],"multi-scale":[52],"modelling":[53],"framework":[54],"takes":[56],"into":[57],"account":[58],"dynamics":[60],"and":[64],"pathway":[65],"production,":[66],"show":[68],"that":[69],"population-based":[70],"offers":[72],"promising":[74],"strategy":[75],"for":[76],"switches.":[81]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}