{"id":"https://openalex.org/W4315488780","doi":"https://doi.org/10.1109/cdc51059.2022.9993154","title":"A coarse-grain model for cellular growth accounting for ribosome synthesis","display_name":"A coarse-grain model for cellular growth accounting for ribosome synthesis","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4315488780","doi":"https://doi.org/10.1109/cdc51059.2022.9993154"},"language":"en","primary_location":{"id":"doi:10.1109/cdc51059.2022.9993154","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/cdc51059.2022.9993154","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.uniroma1.it/bitstream/11573/1682170/1/D%27Angelo_postprint_A-coarse_2022.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064449952","display_name":"Massimiliano d\u2019Angelo","orcid":"https://orcid.org/0000-0002-3017-3557"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Massimiliano d'Angelo","raw_affiliation_strings":["University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","Department of Computer, Control, and Management Engineering \"Antonio Ruberti\", Sapienza University of Rome, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Department of Computer, Control, and Management Engineering \"Antonio Ruberti\", Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069495460","display_name":"Pasquale Palumbo","orcid":"https://orcid.org/0000-0002-9371-2802"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210162062","display_name":"Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti","ror":"https://ror.org/054ye0e45","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasquale Palumbo","raw_affiliation_strings":["University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","Istituto di Analisi dei Sistemi e Informatica \"A. Ruberti\", Italian National Research Council (IASI-CNR), Rome, Italy","SYSBIO-ISBE, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"Istituto di Analisi dei Sistemi e Informatica \"A. Ruberti\", Italian National Research Council (IASI-CNR), Rome, Italy","institution_ids":["https://openalex.org/I4210162062","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"SYSBIO-ISBE, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076124148","display_name":"Stefano Busti","orcid":null},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Busti","raw_affiliation_strings":["University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","SYSBIO-ISBE, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO-ISBE, Milan, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063056739","display_name":"Marco Vanoni","orcid":"https://orcid.org/0000-0002-8690-2587"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Vanoni","raw_affiliation_strings":["University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","SYSBIO-ISBE, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca,Department of Biotechnology and Biosciences,Milan,Italy,20126","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO-ISBE, Milan, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064449952"],"corresponding_institution_ids":["https://openalex.org/I66752286","https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":0.8803,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.76081825,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"3859","last_page":"3864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosome","display_name":"Ribosome","score":0.7893391847610474},{"id":"https://openalex.org/keywords/protein-biosynthesis","display_name":"Protein biosynthesis","score":0.6897084712982178},{"id":"https://openalex.org/keywords/ribosomal-rna","display_name":"Ribosomal RNA","score":0.659232497215271},{"id":"https://openalex.org/keywords/exponential-growth","display_name":"Exponential growth","score":0.5967537760734558},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.4865802526473999},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.47692105174064636},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.45694053173065186},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3823033571243286},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37544524669647217},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.37503746151924133},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3634282350540161},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2602109909057617},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16749629378318787},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.1436012089252472}],"concepts":[{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.7893391847610474},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.6897084712982178},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.659232497215271},{"id":"https://openalex.org/C75235859","wikidata":"https://www.wikidata.org/wiki/Q582659","display_name":"Exponential growth","level":2,"score":0.5967537760734558},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4865802526473999},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.47692105174064636},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45694053173065186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3823033571243286},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37544524669647217},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.37503746151924133},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3634282350540161},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2602109909057617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16749629378318787},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1436012089252472},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cdc51059.2022.9993154","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/cdc51059.2022.9993154","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1682170","is_oa":true,"landing_page_url":"https://hdl.handle.net/11573/1682170","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1682170/1/D%27Angelo_postprint_A-coarse_2022.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:boa.unimib.it:10281/440170","is_oa":false,"landing_page_url":"https://hdl.handle.net/10281/440170","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:iris.uniroma1.it:11573/1682170","is_oa":true,"landing_page_url":"https://hdl.handle.net/11573/1682170","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1682170/1/D%27Angelo_postprint_A-coarse_2022.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/12"}],"awards":[{"id":"https://openalex.org/G8091430692","display_name":null,"funder_award_id":"(MIUR)","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G8848982318","display_name":null,"funder_award_id":"Dipartimenti di Eccellenza 2017","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320317295","display_name":"Dipartimenti di Eccellenza","ror":null},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4315488780.pdf","grobid_xml":"https://content.openalex.org/works/W4315488780.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1756209275","https://openalex.org/W1978542115","https://openalex.org/W1985217551","https://openalex.org/W1992927069","https://openalex.org/W2027257502","https://openalex.org/W2049883153","https://openalex.org/W2067937420","https://openalex.org/W2081298797","https://openalex.org/W2081781433","https://openalex.org/W2091955737","https://openalex.org/W2102992442","https://openalex.org/W2115585439","https://openalex.org/W2129178024","https://openalex.org/W2141803727","https://openalex.org/W2144504620","https://openalex.org/W2161695812","https://openalex.org/W2337217507","https://openalex.org/W2764340206","https://openalex.org/W2794704116","https://openalex.org/W2886001969","https://openalex.org/W2901941802","https://openalex.org/W2953251842","https://openalex.org/W3005281882","https://openalex.org/W3179760805","https://openalex.org/W4239029175","https://openalex.org/W4280594909"],"related_works":["https://openalex.org/W961542009","https://openalex.org/W1995458469","https://openalex.org/W4318955118","https://openalex.org/W2021902173","https://openalex.org/W2008993245","https://openalex.org/W1572513090","https://openalex.org/W2469568055","https://openalex.org/W2330892220","https://openalex.org/W133826215","https://openalex.org/W202078529"],"abstract_inverted_index":{"Protein":[0],"synthesis":[1,137],"in":[2,69,89],"eukaryotes":[3],"is":[4,53,75,100,128],"carried":[5,54,114],"out":[6,55,115],"by":[7,111],"ribosomes,":[8],"large":[9,18,44],"RNA\u2013protein":[10],"complexes":[11],"consisting":[12],"of":[13,50,64,120,135],"a":[14,17,25,58,78,118,142,150],"small":[15,42],"and":[16,35,43,95,138,155],"subunit.":[19],"In":[20],"this":[21],"work":[22],"we":[23],"present":[24],"mathematical":[26],"model":[27,52,87,105,123,127,145],"for":[28,40],"cellular":[29],"growth":[30,71,94,98,140,154],"comprising":[31],"both":[32,41],"protein":[33],"production":[34],"ribosome":[36],"synthesis,":[37],"properly":[38],"accounting":[39],"subunits":[45,68],"dynamics.":[46],"The":[47,125],"qualitative":[48],"analysis":[49],"the":[51,62,65,86,96,104],"according":[56,116],"to":[57,91,117,131,147],"simplifying":[59],"assumption":[60],"on":[61,77,85],"proportion":[63],"two":[66],"ribosomal":[67,136],"stationary":[70],"conditions;":[72],"such":[73],"hypothesis":[74],"based":[76],"reasonable":[79],"biological":[80],"ground.":[81],"Conditions":[82],"are":[83,109],"given":[84],"parameters":[88],"order":[90],"ensure":[92],"exponential":[93],"corresponding":[97],"rate":[99],"straightforwardly":[101],"computed":[102],"from":[103],"parameters.":[106,124],"These":[107],"results":[108],"validated":[110],"numerical":[112],"simulations":[113],"set":[119],"biologically":[121],"meaningful":[122],"modified":[126],"better":[129],"suited":[130],"host":[132],"molecular":[133],"blow-up":[134],"cell":[139],"within":[141],"modular":[143],"whole-cell":[144],"able":[146],"act":[148],"as":[149],"scaffold":[151],"connecting":[152],"metabolism,":[153],"cycle.":[156]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-14T08:04:32.555800","created_date":"2025-10-10T00:00:00"}