{"id":"https://openalex.org/W4315472380","doi":"https://doi.org/10.1109/cdc51059.2022.9992654","title":"Analytical and computational study of the stochastic behavior of a chromatin modification circuit","display_name":"Analytical and computational study of the stochastic behavior of a chromatin modification circuit","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4315472380","doi":"https://doi.org/10.1109/cdc51059.2022.9992654"},"language":"en","primary_location":{"id":"doi:10.1109/cdc51059.2022.9992654","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/cdc51059.2022.9992654","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.mit.edu/bitstream/1721.1/155729/2/SB.CDC2022-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060796056","display_name":"Simone Bruno","orcid":"https://orcid.org/0000-0001-9235-8226"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simone Bruno","raw_affiliation_strings":["Massachusetts Institute of Technology,Department of Mechanical Engineering,Cambridge,MA,02139"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Department of Mechanical Engineering,Cambridge,MA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006692623","display_name":"Ruth Williams","orcid":"https://orcid.org/0000-0003-2822-4324"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth J. Williams","raw_affiliation_strings":["University of California San Diego,Department of Mathematics,La Jolla,CA,92093-0112"],"affiliations":[{"raw_affiliation_string":"University of California San Diego,Department of Mathematics,La Jolla,CA,92093-0112","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036095256","display_name":"Domitilla Del Vecchio","orcid":"https://orcid.org/0000-0001-6472-8576"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domitilla Del Vecchio","raw_affiliation_strings":["Massachusetts Institute of Technology,Department of Mechanical Engineering,Cambridge,MA,02139"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Department of Mechanical Engineering,Cambridge,MA,02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060796056"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47128245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"3871","last_page":"3877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.8734633922576904},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.5263277888298035},{"id":"https://openalex.org/keywords/erasure","display_name":"Erasure","score":0.5243204832077026},{"id":"https://openalex.org/keywords/stochastic-process","display_name":"Stochastic process","score":0.453057199716568},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.44026806950569153},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.425912082195282},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42404627799987793},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.3373037278652191},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.33552688360214233},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28607577085494995},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2619667649269104},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.19001850485801697},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18371057510375977},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17788824439048767},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11918127536773682}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8734633922576904},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5263277888298035},{"id":"https://openalex.org/C2778790127","wikidata":"https://www.wikidata.org/wiki/Q484885","display_name":"Erasure","level":2,"score":0.5243204832077026},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.453057199716568},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.44026806950569153},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.425912082195282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42404627799987793},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3373037278652191},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33552688360214233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28607577085494995},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2619667649269104},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19001850485801697},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18371057510375977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17788824439048767},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11918127536773682},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cdc51059.2022.9992654","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/cdc51059.2022.9992654","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/155729","is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/155729","pdf_url":"https://dspace.mit.edu/bitstream/1721.1/155729/2/SB.CDC2022-2.pdf","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Author","raw_type":"http://purl.org/eprint/type/ConferencePaper"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2v85z6th","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2v85z6th","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:dspace.mit.edu:1721.1/155729","is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/155729","pdf_url":"https://dspace.mit.edu/bitstream/1721.1/155729/2/SB.CDC2022-2.pdf","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Author","raw_type":"http://purl.org/eprint/type/ConferencePaper"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4315472380.pdf","grobid_xml":"https://content.openalex.org/works/W4315472380.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W755194005","https://openalex.org/W1973890190","https://openalex.org/W1976698906","https://openalex.org/W2053156756","https://openalex.org/W2167154952","https://openalex.org/W2279123229","https://openalex.org/W2753419916","https://openalex.org/W2832933424","https://openalex.org/W4225729685","https://openalex.org/W4245296879"],"related_works":["https://openalex.org/W2072016134","https://openalex.org/W1963836821","https://openalex.org/W2522472446","https://openalex.org/W2145740829","https://openalex.org/W2351168932","https://openalex.org/W4281994149","https://openalex.org/W345142232","https://openalex.org/W2108143034","https://openalex.org/W2166797439","https://openalex.org/W2805325890"],"abstract_inverted_index":{"The":[0],"property":[1],"of":[2,21,49,58,82,124,129,139,157,172,195,211],"multicellular":[3],"organisms":[4],"that":[5,134],"allows":[6],"cells":[7],"with":[8,121,146,166,186],"the":[9,18,22,56,67,71,80,101,106,125,136,149,154,159,161,173,181,193,196],"same":[10],"genetic":[11],"code":[12],"to":[13,36,54,69,148],"maintain":[14],"distinct":[15],"identities":[16],"for":[17,99,208],"entire":[19],"life":[20],"organism":[23],"is":[24,143],"known":[25],"as":[26],"epigenetic":[27],"cell":[28],"memory":[29,194,210],"(ECM).":[30],"Recently,":[31],"chromatin":[32,51,113,141],"modifications":[33],"have":[34,37],"appeared":[35],"a":[38,46,50,75,90,204],"key":[39],"role":[40],"in":[41,79,170],"ECM.":[42],"Here,":[43],"we":[44,87,116],"conduct":[45],"stochastic":[47,122],"analysis":[48],"modification":[52],"circuit":[53,92],"determine":[55,95],"effect":[57],"time":[59,108],"scale":[60],"separation":[61],"among":[62],"principal":[63],"system":[64,72],"processes":[65],"on":[66],"extent":[68],"which":[70],"can":[73],"keep":[74],"stable":[76],"steady":[77],"state":[78],"face":[81],"noise.":[83],"To":[84],"this":[85],"end,":[86],"first":[88],"obtain":[89],"reduced":[91],"model":[93],"and":[94,105,111,151,153,175,198],"an":[96],"analytical":[97,119],"expression":[98,213],"both":[100],"stationary":[102,162],"probability":[103],"distribution":[104,163],"switching":[107],"between":[109],"repressed":[110,176,182,199],"active":[112,174,197],"states.":[114,214],"Then,":[115],"validate":[117],"these":[118,187],"results":[120,132],"simulations":[123],"original":[126],"full":[127],"set":[128],"reactions.":[130],"Our":[131],"show":[133],"when":[135],"basal":[137,190],"decay":[138,191],"all":[140,158],"marks":[142],"sufficiently":[144],"slower":[145,189],"respect":[147],"auto":[150],"cross-catalysis":[152],"recruited":[155],"erasure":[156],"marks,":[160],"shows":[164],"bimodality,":[165],"two":[167],"concentrated":[168],"peaks":[169],"correspondence":[171],"states,":[177,200],"but":[178],"biased":[179],"towards":[180],"state.":[183],"In":[184],"accordance":[185],"results,":[188],"extends":[192],"suggesting,":[201],"more":[202],"broadly,":[203],"critical":[205],"design":[206],"principle":[207],"long-lasting":[209],"gene":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
