{"id":"https://openalex.org/W4315472009","doi":"https://doi.org/10.1109/cdc51059.2022.9992536","title":"Frequency-dependent modulation of stochasticity in postsynaptic neuron firing times","display_name":"Frequency-dependent modulation of stochasticity in postsynaptic neuron firing times","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4315472009","doi":"https://doi.org/10.1109/cdc51059.2022.9992536"},"language":"en","primary_location":{"id":"doi:10.1109/cdc51059.2022.9992536","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc51059.2022.9992536","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071667402","display_name":"Zahra Vahdat","orcid":"https://orcid.org/0000-0001-9794-5147"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zahra Vahdat","raw_affiliation_strings":["University of Delaware,Department of Electrical and Computer Engineering,Newark,DE,USA,19716"],"affiliations":[{"raw_affiliation_string":"University of Delaware,Department of Electrical and Computer Engineering,Newark,DE,USA,19716","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022267407","display_name":"Abhyudai Singh","orcid":"https://orcid.org/0000-0002-1451-2838"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhyudai Singh","raw_affiliation_strings":["University of Delaware,Biomedical Engineering, Mathematical Sciences, Center for Bioinformatics and Computational Biology,Department of Electrical and Computer Engineering,Newark,DE,USA,19716"],"affiliations":[{"raw_affiliation_string":"University of Delaware,Biomedical Engineering, Mathematical Sciences, Center for Bioinformatics and Computational Biology,Department of Electrical and Computer Engineering,Newark,DE,USA,19716","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071667402"],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":3.2086,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.94994179,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"635","last_page":"640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.811561107635498},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"Neurotransmission","score":0.6193094253540039},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.6183130741119385},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.5198348164558411},{"id":"https://openalex.org/keywords/neurotransmitter","display_name":"Neurotransmitter","score":0.5129144191741943},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.45878392457962036},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4568820893764496},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.43277472257614136},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3570745587348938},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27390241622924805}],"concepts":[{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.811561107635498},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6193094253540039},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.6183130741119385},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5198348164558411},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5129144191741943},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.45878392457962036},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4568820893764496},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43277472257614136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3570745587348938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27390241622924805},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc51059.2022.9992536","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc51059.2022.9992536","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W187849060","https://openalex.org/W1532842753","https://openalex.org/W1615091949","https://openalex.org/W1915216968","https://openalex.org/W2001520037","https://openalex.org/W2006912466","https://openalex.org/W2009564510","https://openalex.org/W2021907849","https://openalex.org/W2050327333","https://openalex.org/W2051137788","https://openalex.org/W2052426705","https://openalex.org/W2072065849","https://openalex.org/W2076188650","https://openalex.org/W2098328927","https://openalex.org/W2109596721","https://openalex.org/W2124398758","https://openalex.org/W2138775517","https://openalex.org/W2139055855","https://openalex.org/W2147556100","https://openalex.org/W2181170478","https://openalex.org/W2460778061","https://openalex.org/W2505895487","https://openalex.org/W2739895563","https://openalex.org/W2782580631","https://openalex.org/W2906889773","https://openalex.org/W2960312548","https://openalex.org/W3011129205","https://openalex.org/W3018290316","https://openalex.org/W3026696099","https://openalex.org/W3046233527","https://openalex.org/W3098948347","https://openalex.org/W3128516284","https://openalex.org/W3184214471","https://openalex.org/W3184584171","https://openalex.org/W3194374736","https://openalex.org/W4214861334","https://openalex.org/W4223922433","https://openalex.org/W4229831262","https://openalex.org/W4231081240","https://openalex.org/W4294691776","https://openalex.org/W4294691892","https://openalex.org/W4297887305","https://openalex.org/W6809858978","https://openalex.org/W6810432732","https://openalex.org/W6843557942"],"related_works":["https://openalex.org/W2204282720","https://openalex.org/W1595326866","https://openalex.org/W2410102831","https://openalex.org/W2791338400","https://openalex.org/W2176995869","https://openalex.org/W2031287574","https://openalex.org/W1658011278","https://openalex.org/W2021431294","https://openalex.org/W1237059694","https://openalex.org/W4248768296"],"abstract_inverted_index":{"Action":[0],"potential":[1,72,94,111,145],"(AP)-triggered":[2],"neurotransmitter":[3],"release":[4,22,56],"forms":[5],"the":[6,21,63,70,74,83,88,106,110,126,129,142,147,152,157,165,180,191,200,209,213,218,225,244],"key":[7],"basis":[8],"of":[9,23,44,55,73,87,93,131,154,174,211,215,227,246],"inter-neuronal":[10],"communication.":[11],"We":[12,194],"present":[13],"a":[14,27,35,41,52,96,170],"stochastic":[15,237],"hybrid":[16],"system":[17],"model":[18,120],"that":[19,124],"captures":[20],"neurotransmitter-filled":[24],"vesicles":[25,32,133],"from":[26],"presynaptic":[28,64,158,192],"neuron.":[29,65,193],"More":[30],"specifically,":[31],"arrive":[33],"as":[34,208],"Poisson":[36],"process":[37],"to":[38,40,82,95,115,138,161],"attach":[39],"given":[42],"number":[43,130,214],"docking":[45,216],"sites,":[46,217],"and":[47,77,134,146,224],"each":[48],"docked":[49],"vesicle":[50],"has":[51],"certain":[53],"probability":[54,210],"when":[57],"an":[58,102],"AP":[59,103,148,177,188,201,222,247],"is":[60,80],"generated":[61],"in":[62,101,105,128,140,156,169,179,190,199,239],"The":[66,91],"released":[67,132],"neurotransmitters":[68],"enhance":[69,241],"membrane":[71,89,144],"postsynaptic":[75,107,143,166,181],"neuron,":[76,108],"this":[78],"increase":[79],"coupled":[81],"continuous":[84],"exponential":[85],"decay":[86],"potential.":[90],"buildup":[92],"critical":[97],"threshold":[98,220],"level":[99],"results":[100,233],"firing":[104,149,178],"with":[109,186,204],"subsequently":[112],"resetting":[113],"back":[114],"its":[116],"resting":[117],"level.":[118],"Our":[119],"analysis":[121],"develops":[122],"formulas":[123],"quantify":[125],"fluctuations":[127,139],"mechanistically":[135],"connects":[136],"them":[137],"both":[141],"times.":[150,249],"Increasing":[151],"frequency":[153,172,189],"APs":[155],"neuron":[159,182],"leads":[160],"saturation":[162],"effects":[163],"on":[164],"side,":[167],"resulting":[168],"limiting":[171],"range":[173],"neurotransmission.":[175],"Interestingly,":[176],"becomes":[183],"more":[184],"precise":[185],"increasing":[187],"also":[195],"investigate":[196],"how":[197,236],"noise":[198],"timing":[202],"varies":[203],"different":[205],"parameters,":[206],"such":[207],"releases,":[212],"voltage":[219,228],"for":[221],"firing,":[223],"timescale":[226],"decay.":[229],"In":[230],"summary,":[231],"our":[232],"systematically":[234],"explain":[235],"mechanisms":[238],"neurotransmission":[240],"or":[242],"impinge":[243],"precision":[245],"fringing":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5}],"updated_date":"2026-03-31T07:56:22.981413","created_date":"2025-10-10T00:00:00"}
