{"id":"https://openalex.org/W4315488594","doi":"https://doi.org/10.1109/cdc51059.2022.9992437","title":"A Contraction Theory-based Framework for the Design of Robustness to Global Perturbations in Biomolecular Circuits","display_name":"A Contraction Theory-based Framework for the Design of Robustness to Global Perturbations in Biomolecular Circuits","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4315488594","doi":"https://doi.org/10.1109/cdc51059.2022.9992437"},"language":"en","primary_location":{"id":"doi:10.1109/cdc51059.2022.9992437","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/cdc51059.2022.9992437","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081145047","display_name":"Abhilash Patel","orcid":"https://orcid.org/0000-0001-6319-658X"},"institutions":[{"id":"https://openalex.org/I94234084","display_name":"Indian Institute of Technology Kanpur","ror":"https://ror.org/05pjsgx75","country_code":"IN","type":"education","lineage":["https://openalex.org/I94234084"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Abhilash Patel","raw_affiliation_strings":["Indian Institute of Technology,Department of Electrical Engineering,Kanpur,India","Department of Electrical Engineering, Indian Institute of Technology, Kanpur, India"],"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology,Department of Electrical Engineering,Kanpur,India","institution_ids":["https://openalex.org/I94234084"]},{"raw_affiliation_string":"Department of Electrical Engineering, Indian Institute of Technology, Kanpur, India","institution_ids":["https://openalex.org/I94234084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070471808","display_name":"Shaunak Sen","orcid":"https://orcid.org/0000-0002-1412-8633"},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shaunak Sen","raw_affiliation_strings":["Indian Institute of Technology Delhi,Department of Electrical Engineering,New Delhi,India","Department of Electrical Engineering, Indian Institute of Technology Delhi, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Delhi,Department of Electrical Engineering,New Delhi,India","institution_ids":["https://openalex.org/I68891433"]},{"raw_affiliation_string":"Department of Electrical Engineering, Indian Institute of Technology Delhi, New Delhi, India","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051297402","display_name":"Indra Narayan Kar","orcid":null},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Indra Narayan Kar","raw_affiliation_strings":["Indian Institute of Technology Delhi,Department of Electrical Engineering,New Delhi,India","Department of Electrical Engineering, Indian Institute of Technology Delhi, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Delhi,Department of Electrical Engineering,New Delhi,India","institution_ids":["https://openalex.org/I68891433"]},{"raw_affiliation_string":"Department of Electrical Engineering, Indian Institute of Technology Delhi, New Delhi, India","institution_ids":["https://openalex.org/I68891433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081145047"],"corresponding_institution_ids":["https://openalex.org/I94234084"],"apc_list":null,"apc_paid":null,"fwci":0.3539,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52608696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1306","last_page":"1311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12772","display_name":"Control and Stability of Dynamical Systems","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12772","display_name":"Control and Stability of Dynamical Systems","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9724000096321106,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13286","display_name":"Modeling and Simulation Systems","score":0.9639999866485596,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.8654496669769287},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.5898827314376831},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5664450526237488},{"id":"https://openalex.org/keywords/contraction","display_name":"Contraction (grammar)","score":0.5662012100219727},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5657146573066711},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12367287278175354},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10056626796722412}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.8654496669769287},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.5898827314376831},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5664450526237488},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5662012100219727},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5657146573066711},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12367287278175354},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10056626796722412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc51059.2022.9992437","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/cdc51059.2022.9992437","pdf_url":null,"source":{"id":"https://openalex.org/S4363607710","display_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE 61st Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W26528315","https://openalex.org/W1979833590","https://openalex.org/W2004734995","https://openalex.org/W2037913229","https://openalex.org/W2051497876","https://openalex.org/W2068602646","https://openalex.org/W2072120554","https://openalex.org/W2075661042","https://openalex.org/W2100827217","https://openalex.org/W2105758800","https://openalex.org/W2134889984","https://openalex.org/W2135541516","https://openalex.org/W2626249246","https://openalex.org/W2952435295","https://openalex.org/W3034410071","https://openalex.org/W4243369158","https://openalex.org/W4300672336"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"It":[0],"is":[1,24],"challenging":[2],"to":[3,33],"design":[4,26,120],"robustness":[5,122],"against":[6],"global":[7,34,61,84,126],"perturbations":[8,127],"that":[9,30,93],"affect":[10],"the":[11,16,25,60,72,75,78,83,95,99,102,105,118],"plant":[12],"as":[13,15,37,54,65,94,129],"well":[14],"controller.":[17],"A":[18],"particular":[19],"instance":[20],"of":[21,27,121],"practical":[22],"importance":[23],"biomolecular":[28,88,131],"circuits":[29],"are":[31],"robust":[32,111],"variables":[35],"such":[36,128],"temperature.":[38],"To":[39],"address":[40],"this,":[41],"we":[42,91],"developed":[43],"a":[44],"framework":[45],"based":[46],"on":[47,63],"contraction":[48,96],"theory":[49],"and":[50,77,104],"used":[51],"mathematical":[52],"models":[53],"case":[55],"studies.":[56],"We":[57,70],"mathematically":[58],"modelled":[59],"effect":[62],"parameters":[64],"an":[66],"additive":[67],"state-dependent":[68],"uncertainty.":[69],"quantified":[71],"difference":[73],"between":[74,101],"perturbed":[76,106],"nominal":[79,103],"system":[80],"trajectories":[81],"for":[82],"perturbations.":[85],"For":[86],"specific":[87],"circuit":[89],"designs,":[90],"noted":[92],"rate":[97],"increased,":[98],"envelope":[100],"trajectory":[107],"shrunk,":[108],"resulting":[109],"in":[110,117,123,130],"behaviour.":[112],"These":[113],"results":[114],"should":[115],"help":[116],"rational":[119],"systems":[124],"with":[125],"circuits.":[132]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}