{"id":"https://openalex.org/W3011368754","doi":"https://doi.org/10.1109/cdc40024.2019.9028910","title":"Combining transcriptional and translational resource allocation controllers for synthetic circuits","display_name":"Combining transcriptional and translational resource allocation controllers for synthetic circuits","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W3011368754","doi":"https://doi.org/10.1109/cdc40024.2019.9028910","mag":"3011368754"},"language":"en","primary_location":{"id":"doi:10.1109/cdc40024.2019.9028910","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc40024.2019.9028910","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 58th Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067923983","display_name":"Alexander P. S. Darlington","orcid":"https://orcid.org/0000-0001-8025-6329"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexander P. S. Darlington","raw_affiliation_strings":["Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK"],"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK"],"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067923983"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14407013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"6602","last_page":"6609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.7607020139694214},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.6879132390022278},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5786042213439941},{"id":"https://openalex.org/keywords/translational-regulation","display_name":"Translational regulation","score":0.5401709079742432},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.5394433736801147},{"id":"https://openalex.org/keywords/resource-allocation","display_name":"Resource allocation","score":0.5164432525634766},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.43622562289237976},{"id":"https://openalex.org/keywords/ribosome","display_name":"Ribosome","score":0.41453126072883606},{"id":"https://openalex.org/keywords/competition","display_name":"Competition (biology)","score":0.41383984684944153},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.3799832761287689},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3158789873123169},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24104195833206177},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22327366471290588},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.21744269132614136},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.21179771423339844},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.14851221442222595},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08546608686447144}],"concepts":[{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.7607020139694214},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6879132390022278},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5786042213439941},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.5401709079742432},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.5394433736801147},{"id":"https://openalex.org/C29202148","wikidata":"https://www.wikidata.org/wiki/Q287260","display_name":"Resource allocation","level":2,"score":0.5164432525634766},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.43622562289237976},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.41453126072883606},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.41383984684944153},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3799832761287689},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3158789873123169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24104195833206177},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22327366471290588},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.21744269132614136},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.21179771423339844},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.14851221442222595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08546608686447144},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc40024.2019.9028910","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc40024.2019.9028910","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 IEEE 58th Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W954748402","https://openalex.org/W1963204303","https://openalex.org/W1966645118","https://openalex.org/W2037913229","https://openalex.org/W2068741801","https://openalex.org/W2116980992","https://openalex.org/W2148471367","https://openalex.org/W2343741934","https://openalex.org/W2501736566","https://openalex.org/W2741123712","https://openalex.org/W2951697204","https://openalex.org/W2953122708","https://openalex.org/W2995579925","https://openalex.org/W6741633172"],"related_works":["https://openalex.org/W4230687177","https://openalex.org/W1968829728","https://openalex.org/W2349859869","https://openalex.org/W3120118008","https://openalex.org/W4316651471","https://openalex.org/W2051365847","https://openalex.org/W2367249529","https://openalex.org/W2072526354","https://openalex.org/W2027187261","https://openalex.org/W2088885441"],"abstract_inverted_index":{"Recent":[0],"work":[1],"on":[2,52],"engineering":[3],"synthetic":[4],"cellular":[5],"circuitry":[6],"has":[7],"shown":[8],"that":[9,34,96],"non-regulatory":[10],"interactions":[11,97],"brought":[12],"about":[13],"through":[14],"competition":[15],"for":[16,82],"shared":[17],"gene":[18,55],"expression":[19,56],"resources,":[20],"such":[21],"as":[22],"RNA":[23],"polymerase":[24],"and":[25,46,73,85,101,110,120],"ribosomes,":[26],"can":[27,104],"result":[28],"in":[29],"degraded":[30],"performance":[31],"(circuit":[32],"behaviour":[33],"deviates":[35],"from":[36],"design":[37],"specifications)":[38],"or":[39],"even":[40],"failure":[41],"(qualitatively":[42],"different":[43],"functionality).":[44],"Transcriptional":[45],"translational":[47,86,102],"resource":[48,69,91,122],"allocation":[49,92],"controllers":[50,87,103],"based":[51],"orthogonal":[53],"`circuit-specific'":[54],"machineries":[57],"have":[58],"previously":[59],"been":[60],"separately":[61],"designed":[62],"to":[63,106,117],"alleviate":[64],"the":[65,80,99],"impact":[66],"of":[67,108],"this":[68],"competition,":[70],"restoring":[71],"modularity":[72],"improving":[74],"circuit":[75],"performance.":[76],"Here":[77],"we":[78],"investigate":[79],"potential":[81],"combining":[83],"transcriptional":[84,100],"into":[88],"one":[89],"overarching":[90],"system.":[93],"We":[94],"show":[95,111],"between":[98],"lead":[105],"loss":[107],"stability,":[109],"how":[112],"they":[113],"may":[114],"be":[115],"redesigned":[116],"restore":[118],"stable":[119],"robust":[121],"allocation.":[123]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}