{"id":"https://openalex.org/W2913470970","doi":"https://doi.org/10.1109/cdc.2018.8619490","title":"On the Analysis of Cyclic Drug Schedules for Cancer Treatment using Switched Dynamical Systems","display_name":"On the Analysis of Cyclic Drug Schedules for Cancer Treatment using Switched Dynamical Systems","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2913470970","doi":"https://doi.org/10.1109/cdc.2018.8619490","mag":"2913470970"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2018.8619490","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2018.8619490","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009559667","display_name":"Margaret P. Chapman","orcid":"https://orcid.org/0000-0002-2483-6545"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret P. Chapman","raw_affiliation_strings":["Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089549365","display_name":"Eric Mazumdar","orcid":"https://orcid.org/0000-0002-1815-269X"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric V. Mazumdar","raw_affiliation_strings":["Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089281522","display_name":"Ellen M. Langer","orcid":"https://orcid.org/0000-0003-0352-1859"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Langer","raw_affiliation_strings":["Department of Molecular and Medical Genetics, Oregon Health and Science University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, Oregon Health and Science University, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081536984","display_name":"Rosalie C. Sears","orcid":"https://orcid.org/0000-0003-1558-2413"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosalie Sears","raw_affiliation_strings":["Department of Molecular and Medical Genetics, Oregon Health and Science University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, Oregon Health and Science University, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045155646","display_name":"Claire J. Tomlin","orcid":"https://orcid.org/0000-0003-3192-3185"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire J. Tomlin","raw_affiliation_strings":["Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6829,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.95652174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"3503","last_page":"3509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6028875112533569},{"id":"https://openalex.org/keywords/schedule","display_name":"Schedule","score":0.4891796410083771},{"id":"https://openalex.org/keywords/scheduling","display_name":"Scheduling (production processes)","score":0.4723837375640869},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.46614208817481995},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.462239533662796},{"id":"https://openalex.org/keywords/cancer-drugs","display_name":"Cancer drugs","score":0.4264797568321228},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39598309993743896},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3952910304069519},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.26360180974006653},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18360191583633423},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.11842679977416992},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.10983780026435852},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09869596362113953}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6028875112533569},{"id":"https://openalex.org/C68387754","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Schedule","level":2,"score":0.4891796410083771},{"id":"https://openalex.org/C206729178","wikidata":"https://www.wikidata.org/wiki/Q2271896","display_name":"Scheduling (production processes)","level":2,"score":0.4723837375640869},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.46614208817481995},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.462239533662796},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.4264797568321228},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39598309993743896},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3952910304069519},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.26360180974006653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18360191583633423},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.11842679977416992},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10983780026435852},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09869596362113953},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cdc.2018.8619490","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2018.8619490","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"pmh:oai:authors.library.caltech.edu:110737","is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20210903-222215867","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W658474564","https://openalex.org/W1534430411","https://openalex.org/W1620101707","https://openalex.org/W1988878042","https://openalex.org/W2004325824","https://openalex.org/W2041337987","https://openalex.org/W2062974796","https://openalex.org/W2081820338","https://openalex.org/W2082167659","https://openalex.org/W2096218887","https://openalex.org/W2099977591","https://openalex.org/W2116680678","https://openalex.org/W2129375080","https://openalex.org/W2129492921","https://openalex.org/W2135131549","https://openalex.org/W2279253506","https://openalex.org/W2492626689","https://openalex.org/W2568894456","https://openalex.org/W2765084883","https://openalex.org/W2891378535","https://openalex.org/W4235143360"],"related_works":["https://openalex.org/W1982160337","https://openalex.org/W1971380437","https://openalex.org/W1983548084","https://openalex.org/W2141691317","https://openalex.org/W2110846987","https://openalex.org/W2160609742","https://openalex.org/W2979526210","https://openalex.org/W1997414638","https://openalex.org/W2031091109","https://openalex.org/W3205561628"],"abstract_inverted_index":{"Motivated":[0],"by":[1],"our":[2],"prior":[3],"work":[4],"on":[5,185,202],"a":[6,31,39,178,193],"Triple":[7,203],"Negative":[8,204],"breast":[9,205],"cancer":[10,22,85,107,132,206],"cell":[11,86,108,133,207],"line,":[12],"the":[13,25,68,83,101,105,122,141,155,167,186,190],"focus":[14],"of":[15,27,42,67,104,124,143,157,169],"this":[16],"paper":[17,191],"is":[18,55,135],"controller":[19],"synthesis":[20],"for":[21,128,163],"treatment,":[23],"through":[24],"use":[26],"drug":[28,50,54],"scheduling":[29],"and":[30,77,97,176],"switched":[32],"dynamical":[33],"system":[34],"model.":[35],"Here":[36],"we":[37,111,160,172],"study":[38],"cyclic":[40],"schedule":[41],"d":[43,69],"drugs":[44,70,80,90],"with":[45,192],"maximal":[46],"waiting":[47,114],"times":[48],"between":[49],"inputs,":[51],"where":[52],"each":[53,129],"applied":[56],"once":[57],"per":[58],"cycle":[59],"in":[60],"any":[61],"order.":[62],"We":[63,188],"suppose":[64],"that":[65,78,113,196],"some":[66],"are":[71,91,126],"highly":[72],"toxic":[73,93],"to":[74,94,118,121,137,147],"normal":[75,95],"cells":[76,96,145],"these":[79],"can":[81,98],"shrink":[82],"live":[84,106,144],"population.":[87,109],"The":[88],"remaining":[89],"less":[92],"only":[99],"reduce":[100],"growth":[102],"rate":[103],"Also,":[110],"assume":[112],"time":[115,150],"bounds":[116],"related":[117],"toxicity,":[119],"or":[120],"onset":[123],"resistance,":[125],"available":[127],"drug.":[130],"A":[131],"population":[134],"said":[136],"be":[138],"stable":[139],"if":[140],"number":[142],"tends":[146],"zero,":[148],"as":[149],"becomes":[151],"sufficiently":[152],"large.":[153],"In":[154,166],"absence":[156],"modeling":[158,170],"error,":[159,171],"derive":[161,177],"conditions":[162,184],"exponential":[164,174],"stability.":[165],"presence":[168],"prove":[173],"stability":[175],"settling":[179],"time,":[180],"under":[181],"certain":[182],"mathematical":[183],"error.":[187],"conclude":[189],"numerical":[194],"example":[195],"uses":[197],"models":[198],"which":[199],"were":[200],"identified":[201],"line":[208],"data.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
