{"id":"https://openalex.org/W2950265181","doi":"https://doi.org/10.1109/cdc.2018.8619371","title":"Extrinsic Noise Suppression in Micro RNA Mediated Incoherent Feedforward Loops","display_name":"Extrinsic Noise Suppression in Micro RNA Mediated Incoherent Feedforward Loops","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2950265181","doi":"https://doi.org/10.1109/cdc.2018.8619371","mag":"2950265181"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2018.8619371","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2018.8619371","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110619272","display_name":"Alberto Carignano","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alberto Carignano","raw_affiliation_strings":["Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075692191","display_name":"Sumit Mukherjee","orcid":"https://orcid.org/0000-0001-6532-3343"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumit Mukherjee","raw_affiliation_strings":["Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022267407","display_name":"Abhyudai Singh","orcid":"https://orcid.org/0000-0002-1451-2838"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhyudai Singh","raw_affiliation_strings":["Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021731745","display_name":"Georg Seelig","orcid":"https://orcid.org/0000-0002-3163-8782"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georg Seelig","raw_affiliation_strings":["Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7423,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.71451668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"4353","last_page":"4359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feed-forward","display_name":"Feed forward","score":0.7465139627456665},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6461133360862732},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.640634298324585},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.577486515045166},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.5130959749221802},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.43342238664627075},{"id":"https://openalex.org/keywords/noise-suppression","display_name":"Noise suppression","score":0.43306785821914673},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3441891670227051},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.34224772453308105},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3343769609928131},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32219767570495605},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24219265580177307},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15750399231910706},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.15482932329177856},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.1278863251209259},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.12509089708328247},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10617455840110779},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.08844822645187378},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08650901913642883},{"id":"https://openalex.org/keywords/bandwidth","display_name":"Bandwidth (computing)","score":0.08399680256843567},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.0641196072101593}],"concepts":[{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.7465139627456665},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6461133360862732},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.640634298324585},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.577486515045166},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.5130959749221802},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.43342238664627075},{"id":"https://openalex.org/C2987345804","wikidata":"https://www.wikidata.org/wiki/Q583234","display_name":"Noise suppression","level":3,"score":0.43306785821914673},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3441891670227051},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.34224772453308105},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3343769609928131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32219767570495605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24219265580177307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15750399231910706},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.15482932329177856},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.1278863251209259},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.12509089708328247},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10617455840110779},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08844822645187378},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08650901913642883},{"id":"https://openalex.org/C2776257435","wikidata":"https://www.wikidata.org/wiki/Q1576430","display_name":"Bandwidth (computing)","level":2,"score":0.08399680256843567},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0641196072101593},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2018.8619371","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2018.8619371","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1519953847","https://openalex.org/W1669686402","https://openalex.org/W1753309339","https://openalex.org/W1972206112","https://openalex.org/W1973339647","https://openalex.org/W1973960290","https://openalex.org/W1977905073","https://openalex.org/W1978402873","https://openalex.org/W1983907180","https://openalex.org/W2020596227","https://openalex.org/W2030362521","https://openalex.org/W2032446791","https://openalex.org/W2043564861","https://openalex.org/W2043946672","https://openalex.org/W2045958909","https://openalex.org/W2072893505","https://openalex.org/W2073094004","https://openalex.org/W2077336113","https://openalex.org/W2099551708","https://openalex.org/W2117298796","https://openalex.org/W2127793379","https://openalex.org/W2133297762","https://openalex.org/W2134543131","https://openalex.org/W2135541516","https://openalex.org/W2147556100","https://openalex.org/W2150055571","https://openalex.org/W2155202381","https://openalex.org/W2156534285","https://openalex.org/W2158341634","https://openalex.org/W2159579373","https://openalex.org/W2267017199","https://openalex.org/W2314232199","https://openalex.org/W2314564135","https://openalex.org/W2402827159","https://openalex.org/W2727980082","https://openalex.org/W4232123484","https://openalex.org/W6661433012"],"related_works":["https://openalex.org/W2286391053","https://openalex.org/W2982600058","https://openalex.org/W1963486701","https://openalex.org/W2959845408","https://openalex.org/W1975446599","https://openalex.org/W1993592538","https://openalex.org/W2508432588","https://openalex.org/W2750346291","https://openalex.org/W2950265181","https://openalex.org/W2891557543"],"abstract_inverted_index":{"MicroRNA":[0],"mediated":[1,83],"incoherent":[2],"feed":[3,50,84,149,195],"forward":[4,51,85,150,196],"loops":[5],"(IFFLs)":[6],"are":[7,40,60,166],"recurrent":[8],"network":[9,86],"motifs":[10],"in":[11,143,181,204],"mammalian":[12],"cells":[13],"and":[14,25,39,97,104,163,190],"have":[15],"been":[16,56],"a":[17,147,153],"topic":[18],"of":[19,93,118,131,139,146,156,179],"study":[20],"for":[21,81],"their":[22],"noise":[23,44,65,79,102,110,133,142],"rejection":[24,80,138],"buffering":[26],"properties.":[27],"Previous":[28],"work":[29,70],"showed":[30],"that":[31,58,75,124,174],"IFFLs":[32],"can":[33,127,198],"adapt":[34],"to":[35,43,77,186],"varying":[36],"promoter":[37],"activity":[38],"less":[41],"prone":[42],"than":[45,66],"similar":[46],"circuits":[47],"without":[48],"the":[49,72,91,106,116,129,144,157,161,177,182,187,194],"loop.":[52],"Furthermore,":[53],"it":[54],"has":[55],"shown":[57],"microRNAs":[59],"better":[61],"at":[62],"rejecting":[63],"extrinsic":[64,78,101,120,132,141,183],"intrinsic":[67],"noise.":[68],"This":[69],"studies":[71],"biological":[73],"mechanisms":[74],"lead":[76],"microRNA":[82,162,191],"motifs.":[87],"Specifically,":[88],"we":[89,122,172],"compare":[90],"effects":[92],"microRNA-induced":[94],"mRNA":[95,165],"degradation":[96],"translational":[98,125],"inhibition":[99,126],"on":[100,176],"rejection,":[103],"identify":[105],"parameter":[107],"regimes":[108],"where":[109,160],"is":[111],"most":[112],"efficiently":[113],"rejected.":[114],"In":[115],"case":[117,145,155],"static":[119],"noise,":[121],"find":[123],"expand":[128],"regime":[130],"rejection.":[134],"We":[135],"then":[136],"analyze":[137],"dynamic":[140],"single-gene":[148],"loop":[151,197],"(sgFFL),":[152],"special":[154,170],"IFFL":[158],"motif":[159],"target":[164],"co-expressed.":[167],"For":[168],"this":[169],"case,":[171],"demonstrate":[173],"depending":[175],"time-scale":[178],"fluctuations":[180,203],"variable":[184],"compared":[185],"mRN":[188],"A":[189],"decay":[192],"rates,":[193],"both":[199],"buffer":[200],"or":[201],"amplify":[202],"gene":[205],"product":[206],"copy":[207],"numbers.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}