{"id":"https://openalex.org/W2783864625","doi":"https://doi.org/10.1109/cdc.2017.8263882","title":"The autorepressor: A case study of the importance of model selection","display_name":"The autorepressor: A case study of the importance of model selection","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2783864625","doi":"https://doi.org/10.1109/cdc.2017.8263882","mag":"2783864625"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2017.8263882","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2017.8263882","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 56th Annual Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062283074","display_name":"Andreas W. K. Harris","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andreas W. K. Harris","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001547547","display_name":"Ciar\u00e1n L. Kelly","orcid":"https://orcid.org/0000-0002-2263-5176"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ciaran L. Kelly","raw_affiliation_strings":["Imperial College London, Centre for Synthetic Biology and Innovation, London, UK"],"affiliations":[{"raw_affiliation_string":"Imperial College London, Centre for Synthetic Biology and Innovation, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034003551","display_name":"Harrison Steel","orcid":"https://orcid.org/0000-0002-9625-4755"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harrison Steel","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053811056","display_name":"Antonis Papachristodoulou","orcid":"https://orcid.org/0000-0002-3565-8967"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonis Papachristodoulou","raw_affiliation_strings":["Department of Engineering Science, University of Oxford, Oxford, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062283074"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.4491,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64878311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1622","last_page":"1627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.8128286004066467},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6874632239341736},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6208274960517883},{"id":"https://openalex.org/keywords/tetr","display_name":"TetR","score":0.5834224224090576},{"id":"https://openalex.org/keywords/inducer","display_name":"Inducer","score":0.5102617740631104},{"id":"https://openalex.org/keywords/design-of-experiments","display_name":"Design of experiments","score":0.4880017340183258},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.44389161467552185},{"id":"https://openalex.org/keywords/experimental-data","display_name":"Experimental data","score":0.4262012541294098},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2561383545398712},{"id":"https://openalex.org/keywords/repressor","display_name":"Repressor","score":0.22932732105255127},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.19923299551010132},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13667866587638855},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11953312158584595},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11047685146331787}],"concepts":[{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.8128286004066467},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6874632239341736},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6208274960517883},{"id":"https://openalex.org/C2777274385","wikidata":"https://www.wikidata.org/wiki/Q24778590","display_name":"TetR","level":5,"score":0.5834224224090576},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.5102617740631104},{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.4880017340183258},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.44389161467552185},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.4262012541294098},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2561383545398712},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.22932732105255127},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.19923299551010132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13667866587638855},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11953312158584595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11047685146331787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cdc.2017.8263882","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2017.8263882","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 IEEE 56th Annual Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"pmh:oai:nrl.northumbria.ac.uk:40863","is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/id/eprint/40863/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference or Workshop Item"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:d735abca-09c2-4d38-b840-2a5cf39d64bf","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:d735abca-09c2-4d38-b840-2a5cf39d64bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference item"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4211132343","display_name":null,"funder_award_id":"EP/M002454/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8511057088","display_name":null,"funder_award_id":"EP/I031944/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1523595721","https://openalex.org/W1526225007","https://openalex.org/W1567351510","https://openalex.org/W1590222219","https://openalex.org/W1599969036","https://openalex.org/W1645305843","https://openalex.org/W1670175012","https://openalex.org/W1995700438","https://openalex.org/W2001841300","https://openalex.org/W2007090643","https://openalex.org/W2033783472","https://openalex.org/W2047781459","https://openalex.org/W2061425021","https://openalex.org/W2063390098","https://openalex.org/W2091239006","https://openalex.org/W2126602684","https://openalex.org/W2140347764","https://openalex.org/W2147745135","https://openalex.org/W2147851940","https://openalex.org/W2148641266","https://openalex.org/W2150966574","https://openalex.org/W2156781574","https://openalex.org/W2160803964","https://openalex.org/W2166744717","https://openalex.org/W2206867185","https://openalex.org/W2305757214","https://openalex.org/W2477731233","https://openalex.org/W2752943112","https://openalex.org/W2950135916","https://openalex.org/W6743688073"],"related_works":["https://openalex.org/W2171535756","https://openalex.org/W2078305275","https://openalex.org/W2030961787","https://openalex.org/W4205134593","https://openalex.org/W2147565937","https://openalex.org/W2135140337","https://openalex.org/W2078769518","https://openalex.org/W2781019704","https://openalex.org/W3006986361","https://openalex.org/W2018821946"],"abstract_inverted_index":{"Major":[0],"challenges":[1],"exist":[2],"in":[3,18,76,108,121],"the":[4,17,62,68,87,99,115,120,125,133],"design":[5,22],"of":[6,11,23,31,40,52,83,93,101,127],"gene":[7],"regulatory":[8],"networks.":[9],"Some":[10],"these":[12,94],"can":[13],"be":[14,46,153,177],"addressed":[15],"by":[16,162,173],"silico":[19],"modelling":[20,30,86,139,175],"and":[21,54,78,91,118,167,170],"systems":[24],"prior":[25],"to":[26,66,85,97,155,179],"implementation.":[27],"However,":[28],"reliable":[29],"a":[32,38,49,71,104,138,149],"given":[33],"system":[34,113],"is":[35,95],"predicated":[36],"upon":[37],"range":[39,51],"simplifying":[41],"assumptions":[42],"which":[43,174],"may":[44,152],"only":[45],"valid":[47],"for":[48],"limited":[50],"architectures":[53],"experimental":[55,158,166],"conditions.":[56],"In":[57],"this":[58,112],"paper":[59],"we":[60],"study":[61],"autorepressor,":[63],"also":[64],"referred":[65],"as":[67],"negative":[69],"autoregulator,":[70],"genetic":[72],"motif":[73],"common":[74],"both":[75],"natural":[77],"synthetic":[79],"circuits.":[80],"A":[81],"number":[82],"approaches":[84,172],"autorepressor":[88],"are":[89],"presented,":[90],"one":[92],"extended":[96,178],"include":[98],"impact":[100],"inducer":[102,143],"consumption,":[103],"phenomenon":[105],"frequently":[106],"observed":[107,182],"experiments.":[109],"We":[110,135,160],"implement":[111],"using":[114,129],"tet-repressor":[116],"(TetR),":[117],"compare":[119],"vivo":[122],"data":[123],"with":[124,148],"results":[126],"simulations":[128],"parameters":[130],"taken":[131],"from":[132],"literature.":[134],"demonstrate":[136],"that":[137,141],"approach":[140],"considers":[142],"sequestration":[144],"due":[145],"its":[146],"binding":[147],"transcription":[150],"factor":[151],"required":[154],"qualitatively":[156],"replicate":[157],"results.":[159],"conclude":[161],"drawing":[163],"comparisons":[164],"between":[165],"simulated":[168],"results,":[169],"discuss":[171],"could":[176],"better":[180],"represent":[181],"behaviours.":[183]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}