{"id":"https://openalex.org/W2774500757","doi":"https://doi.org/10.1109/cdc.2015.7402383","title":"Optimized prediction of extreme treatment outcomes in ovarian cancer","display_name":"Optimized prediction of extreme treatment outcomes in ovarian cancer","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2774500757","doi":"https://doi.org/10.1109/cdc.2015.7402383","mag":"2774500757"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2015.7402383","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2015.7402383","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 54th IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041219457","display_name":"Burook Misganaw","orcid":null},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Burook Misganaw","raw_affiliation_strings":["Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX"],"affiliations":[{"raw_affiliation_string":"Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003021606","display_name":"Eren Ahsen","orcid":null},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eren Ahsen","raw_affiliation_strings":["Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX"],"affiliations":[{"raw_affiliation_string":"Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107841671","display_name":"Nitin Kumar Singh","orcid":null},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Singh","raw_affiliation_strings":["Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX"],"affiliations":[{"raw_affiliation_string":"Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105842546","display_name":"Keith Baggerly","orcid":null},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith A. Baggerly","raw_affiliation_strings":["Department of Bioinformatics and Computational Biology, M. D. Anderson Cancer Center, Houston, TX"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Computational Biology, M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108140377","display_name":"Anna K. Unruh","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Unruh","raw_affiliation_strings":["UT Graduate School of the Biomedical Sciences"],"affiliations":[{"raw_affiliation_string":"UT Graduate School of the Biomedical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088421747","display_name":"Michael A. White","orcid":"https://orcid.org/0000-0001-6772-1388"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]},{"id":"https://openalex.org/I4210096815","display_name":"Southwestern Medical Center","ror":"https://ror.org/00t9vx427","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096815"]},{"id":"https://openalex.org/I4388891891","display_name":"Southwestern Medical Center","ror":"https://ror.org/05d80e146","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. White","raw_affiliation_strings":["UT Southwestern Medical Center, Dallas, TX"],"affiliations":[{"raw_affiliation_string":"UT Southwestern Medical Center, Dallas, TX","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210096815","https://openalex.org/I4388891891"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089027398","display_name":"M. Vidyasagar","orcid":"https://orcid.org/0000-0003-1057-1942"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Vidyasagar","raw_affiliation_strings":["Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX"],"affiliations":[{"raw_affiliation_string":"Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, Richardson, TX","institution_ids":["https://openalex.org/I162577319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5041219457"],"corresponding_institution_ids":["https://openalex.org/I162577319"],"apc_list":null,"apc_paid":null,"fwci":1.0352,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.8161102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"470","issue":null,"first_page":"1254","last_page":"1258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9819999933242798,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.624580442905426},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4803682267665863},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.37112414836883545},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3523678183555603},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26773732900619507},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2546767592430115}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.624580442905426},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4803682267665863},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37112414836883545},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3523678183555603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26773732900619507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2546767592430115}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2015.7402383","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2015.7402383","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 54th IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1749992802","https://openalex.org/W1970134315","https://openalex.org/W2000197817","https://openalex.org/W2002617966","https://openalex.org/W2009514656","https://openalex.org/W2011645162","https://openalex.org/W2087220508","https://openalex.org/W2089607969","https://openalex.org/W2098421558","https://openalex.org/W2099911815","https://openalex.org/W2107693044","https://openalex.org/W2123696077","https://openalex.org/W2125089526","https://openalex.org/W2131593373","https://openalex.org/W2134785517","https://openalex.org/W2136609875","https://openalex.org/W2143426320","https://openalex.org/W2148847512","https://openalex.org/W2157630129","https://openalex.org/W2167921077","https://openalex.org/W2170552969","https://openalex.org/W2220812108"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"The":[0,221],"TCGA":[1,94,197,205],"ovarian":[2,95],"cancer":[3,96],"database":[4],"shows":[5],"that":[6,51,106,141,170,178],"about":[7],"10%":[8,29],"of":[9,35,58,71,115,135,139,150,185,243],"patients":[10,147,173],"respond":[11],"poorly":[12],"to":[13,53,68,87,130,145,165,216],"platinum-based":[14],"chemotherapy,":[15],"with":[16],"tumors":[17],"relapsing":[18],"in":[19,81],"seven":[20],"months":[21],"or":[22,30,38],"less.":[23],"At":[24,41],"the":[25,55,84,101,189,196,204,224,232,239],"other":[26],"extreme,":[27],"another":[28,91],"so":[31],"enjoy":[32],"disease-free":[33],"survival":[34,56,183],"three":[36,151],"years":[37],"more":[39,45],"[1].":[40],"present":[42],"there":[43,179],"are":[44,128,162,236],"than":[46,77],"a":[47,59,112,120,132,167,181],"dozen":[48],"prognostic":[49],"signatures":[50,73],"claim":[52],"predict":[54],"prospects":[57],"patient":[60],"based":[61],"on":[62,203,223,234],"her":[63],"genetic":[64],"profile.":[65],"Yet,":[66],"according":[67],"[2],":[69],"none":[70],"these":[72],"performs":[74],"significantly":[75],"better":[76],"pure":[78],"guessing.":[79],"Accordingly,":[80],"this":[82,125],"paper":[83],"objective":[85],"is":[86,98,107,180,193,227],"propose":[88],"and":[89,158,201],"validate":[90],"gene-based":[92],"signature.":[93],"data":[97,214,226],"analyzed":[99],"using":[100,195],"\u201clone":[102],"star\u201d":[103],"algorithm":[104],"[3]":[105],"specifically":[108],"developed":[109,194],"for":[110],"identifying":[111],"small":[113],"number":[114],"highly":[116],"predictive":[117],"features":[118],"from":[119],"very":[121],"large":[122],"set.":[123],"Using":[124],"algorithm,":[126],"we":[127],"able":[129,164],"identify":[131],"biomarker":[133],"panel":[134],"25":[136],"genes":[137],"(out":[138],"12,000)":[140],"can":[142,171],"be":[143],"used":[144],"classify":[146],"into":[148,174],"one":[149,186],"groups:":[152],"super-responders":[153],"(SR),":[154],"medium":[155],"responders":[156],"(MR),":[157],"non-responders":[159],"(NR).":[160],"We":[161],"also":[163],"determine":[166],"discriminant":[168],"function":[169],"divide":[172],"two":[175],"classes,":[176],"such":[177],"clear":[182],"advantage":[184],"group":[187],"over":[188],"other.":[190],"This":[191],"signature":[192],"Agilent":[198],"platform":[199,207],"data,":[200,208],"cross-validated":[202],"Affymetrix":[206],"as":[209,211],"well":[210,237],"entirely":[212],"independent":[213],"due":[215],"Tothill":[217],"et":[218],"al.":[219],"[4].":[220],"P-value":[222],"training":[225],"below":[228,238],"machine":[229],"zero,":[230],"while":[231],"P-values":[233],"cross-validation":[235],"widely":[240],"accepted":[241],"threshold":[242],"0.05.":[244]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}