{"id":"https://openalex.org/W2067610869","doi":"https://doi.org/10.1109/cdc.2013.6760515","title":"On periodic reference tracking using batch-mode reinforcement learning with application to gene regulatory network control","display_name":"On periodic reference tracking using batch-mode reinforcement learning with application to gene regulatory network control","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2067610869","doi":"https://doi.org/10.1109/cdc.2013.6760515","mag":"2067610869"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2013.6760515","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2013.6760515","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"52nd IEEE Conference on Decision and Control","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011097340","display_name":"Aivar Sootla","orcid":"https://orcid.org/0000-0003-4666-4454"},"institutions":[{"id":"https://openalex.org/I4210118210","display_name":"ARC Centre of Excellence in Synthetic Biology","ror":"https://ror.org/01p2zg436","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1337719021","https://openalex.org/I2801453606","https://openalex.org/I4210118210","https://openalex.org/I4210132349","https://openalex.org/I99043593"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Aivar Sootla","raw_affiliation_strings":["Department of Bioengineering, Centre for Synthetic Biology and Innovation","Department of Bioengineering, Centre for Synthetic Biology and Innovation, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Centre for Synthetic Biology and Innovation","institution_ids":["https://openalex.org/I4210118210"]},{"raw_affiliation_string":"Department of Bioengineering, Centre for Synthetic Biology and Innovation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042190824","display_name":"Natalja Strelkowa","orcid":null},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Natalja Strelkowa","raw_affiliation_strings":["Boehringer-Ingelheim Pharma GmbH & Co KG., Germany","Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim Am Rhein, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer-Ingelheim Pharma GmbH & Co KG., Germany","institution_ids":["https://openalex.org/I1330995197"]},{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim Am Rhein, Germany;","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109834940","display_name":"Damien Ernst","orcid":null},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Damien Ernst","raw_affiliation_strings":["Montefiore Institute, University of Li'ege, Belgium","[Montefiore Institute, University of Liege, Li\u00e8ge, Belgium]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montefiore Institute, University of Li'ege, Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"[Montefiore Institute, University of Liege, Li\u00e8ge, Belgium]","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058010593","display_name":"Mauricio Barahona","orcid":"https://orcid.org/0000-0002-1089-5675"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mauricio Barahona","raw_affiliation_strings":["Department of Mathematics, Imperial College London, UK","Dept. of Math., Imperial Coll. London, London, UK#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Dept. of Math., Imperial Coll. London, London, UK#TAB#","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086007559","display_name":"Guy\u2010Bart Stan","orcid":"https://orcid.org/0000-0002-5560-902X"},"institutions":[{"id":"https://openalex.org/I4210118210","display_name":"ARC Centre of Excellence in Synthetic Biology","ror":"https://ror.org/01p2zg436","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1337719021","https://openalex.org/I2801453606","https://openalex.org/I4210118210","https://openalex.org/I4210132349","https://openalex.org/I99043593"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Guy-Bart Stan","raw_affiliation_strings":["Department of Bioengineering, Centre for Synthetic Biology and Innovation","Department of Bioengineering, Centre for Synthetic Biology and Innovation, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Centre for Synthetic Biology and Innovation","institution_ids":["https://openalex.org/I4210118210"]},{"raw_affiliation_string":"Department of Bioengineering, Centre for Synthetic Biology and Innovation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2992,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62264195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"4086","last_page":"4091"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"Reinforcement learning","score":0.7449015974998474},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.7234508991241455},{"id":"https://openalex.org/keywords/trajectory","display_name":"Trajectory","score":0.7127736806869507},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.7078902721405029},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6441876888275146},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5783388614654541},{"id":"https://openalex.org/keywords/mode","display_name":"Mode (computer interface)","score":0.532292902469635},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.4735269546508789},{"id":"https://openalex.org/keywords/reference-model","display_name":"Reference model","score":0.42453593015670776},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4201202392578125},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.3808896243572235},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3172529339790344}],"concepts":[{"id":"https://openalex.org/C97541855","wikidata":"https://www.wikidata.org/wiki/Q830687","display_name":"Reinforcement learning","level":2,"score":0.7449015974998474},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.7234508991241455},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.7127736806869507},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.7078902721405029},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6441876888275146},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5783388614654541},{"id":"https://openalex.org/C48677424","wikidata":"https://www.wikidata.org/wiki/Q6888088","display_name":"Mode (computer interface)","level":2,"score":0.532292902469635},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.4735269546508789},{"id":"https://openalex.org/C150189527","wikidata":"https://www.wikidata.org/wiki/Q356674","display_name":"Reference model","level":2,"score":0.42453593015670776},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4201202392578125},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.3808896243572235},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3172529339790344},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2013.6760515","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2013.6760515","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"52nd IEEE Conference on Decision and Control","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.550000011920929,"display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G5038689827","display_name":null,"funder_award_id":"EP/J014214/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8072351262","display_name":null,"funder_award_id":"EP/G036004/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W166862392","https://openalex.org/W1550698229","https://openalex.org/W1626155273","https://openalex.org/W1645305843","https://openalex.org/W1894549422","https://openalex.org/W2003885556","https://openalex.org/W2011301426","https://openalex.org/W2020652110","https://openalex.org/W2021022239","https://openalex.org/W2031822229","https://openalex.org/W2056132907","https://openalex.org/W2057458673","https://openalex.org/W2101234009","https://openalex.org/W2120346334","https://openalex.org/W2121863487","https://openalex.org/W2126733261","https://openalex.org/W2134689794","https://openalex.org/W2160740951","https://openalex.org/W2165612525","https://openalex.org/W2165878769","https://openalex.org/W2950511172","https://openalex.org/W3005347330","https://openalex.org/W3103886388","https://openalex.org/W4214717370","https://openalex.org/W4245296547","https://openalex.org/W4285719527","https://openalex.org/W4297938971","https://openalex.org/W6675354045","https://openalex.org/W6677737365"],"related_works":["https://openalex.org/W17155033","https://openalex.org/W3207760230","https://openalex.org/W1496222301","https://openalex.org/W1590307681","https://openalex.org/W2536018345","https://openalex.org/W4312814274","https://openalex.org/W4285370786","https://openalex.org/W2296488620","https://openalex.org/W2358353312","https://openalex.org/W2353836703"],"abstract_inverted_index":{"In":[0,34],"this":[1],"paper,":[2],"we":[3,36],"consider":[4],"the":[5,11,26,50,67,71,79,88,102,120],"periodic":[6,51,57],"reference":[7,52,58,72,91],"tracking":[8,53,59,92,121],"problem":[9,89],"in":[10],"framework":[12],"of":[13,29,32,66,70,81,90],"batch-mode":[14,40],"reinforcement":[15,41],"learning,":[16],"which":[17,113],"studies":[18],"methods":[19],"for":[20,93,119],"solving":[21],"optimal":[22],"control":[23],"problems":[24],"from":[25],"sole":[27],"knowledge":[28,65],"a":[30,63,94],"set":[31],"trajectories.":[33],"particular,":[35],"extend":[37],"an":[38,116],"existing":[39],"learning":[42],"algorithm,":[43],"known":[44,100],"as":[45,101],"Fitted":[46],"Q":[47],"Iteration,":[48],"to":[49],"problem.":[54,122],"The":[55],"presented":[56],"algorithm":[60],"explicitly":[61],"exploits":[62],"priori":[64],"future":[68],"values":[69],"trajectory":[73],"and":[74,84],"its":[75],"periodicity.":[76],"We":[77],"discuss":[78],"properties":[80],"our":[82],"approach":[83],"illustrate":[85],"it":[86,115],"on":[87],"synthetic":[95],"biology":[96],"gene":[97],"regulatory":[98],"network":[99],"generalised":[103],"repressilator.":[104],"This":[105],"system":[106],"can":[107],"produce":[108],"decaying":[109],"but":[110],"long-lived":[111],"oscillations,":[112],"makes":[114],"interesting":[117],"application":[118]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}