{"id":"https://openalex.org/W2060491831","doi":"https://doi.org/10.1109/cdc.2013.6759870","title":"The impact of insulin pharmacokinetics and pharmacodynamics on the closed-loop artificial pancreas","display_name":"The impact of insulin pharmacokinetics and pharmacodynamics on the closed-loop artificial pancreas","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2060491831","doi":"https://doi.org/10.1109/cdc.2013.6759870","mag":"2060491831"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2013.6759870","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2013.6759870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"52nd IEEE Conference on Decision and Control","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012927303","display_name":"Justin J. Lee","orcid":"https://orcid.org/0000-0002-4246-3316"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin J. Lee","raw_affiliation_strings":["Sansum Diabetes Research Institute, Santa Barbara, CA, USA","University of California Santa Barbara Santa Barbara, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I4210104828"]},{"raw_affiliation_string":"University of California Santa Barbara Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007855159","display_name":"Eyal Dassau","orcid":"https://orcid.org/0000-0001-5333-6892"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eyal Dassau","raw_affiliation_strings":["Sansum Diabetes Research Institute, Santa Barbara, CA, USA","University of California Santa Barbara Santa Barbara, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I4210104828"]},{"raw_affiliation_string":"University of California Santa Barbara Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058224179","display_name":"Howard Zisser","orcid":"https://orcid.org/0000-0002-8927-9671"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Zisser","raw_affiliation_strings":["Sansum Diabetes Research Institute, Santa Barbara, CA, USA","University of California Santa Barbara Santa Barbara, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I4210104828"]},{"raw_affiliation_string":"University of California Santa Barbara Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002265183","display_name":"William V. Tamborlane","orcid":"https://orcid.org/0000-0002-9928-559X"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Tamborlane","raw_affiliation_strings":["School of Medicine, Yale University, New Haven, CT, USA","School of Medicine, Yale University, New Haven CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"School of Medicine, Yale University, New Haven CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045100820","display_name":"Stuart A. Weinzimer","orcid":"https://orcid.org/0000-0002-7768-5189"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Weinzimer","raw_affiliation_strings":["School of Medicine, Yale University, New Haven, CT, USA","School of Medicine, Yale University, New Haven CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"School of Medicine, Yale University, New Haven CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081288689","display_name":"Francis J. Doyle","orcid":"https://orcid.org/0000-0002-3293-9114"},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I4210104828","display_name":"Sansum Diabetes Research Institute","ror":"https://ror.org/01kq6ye20","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104828"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis J. Doyle","raw_affiliation_strings":["Sansum Diabetes Research Institute, Santa Barbara, CA, USA","University of California Santa Barbara Santa Barbara, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sansum Diabetes Research Institute, Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I4210104828"]},{"raw_affiliation_string":"University of California Santa Barbara Santa Barbara, CA, USA","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0835,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.89309211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"61","issue":null,"first_page":"127","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.9812999963760376,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-pancreas","display_name":"Artificial pancreas","score":0.7597454190254211},{"id":"https://openalex.org/keywords/postprandial","display_name":"Postprandial","score":0.7233768105506897},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.660658061504364},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.6585626602172852},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.6440783739089966},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.5025942325592041},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.4305555522441864},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41815340518951416},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.38349631428718567},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.3826351761817932},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.32497847080230713},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21126344799995422},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.1892406940460205},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.17768627405166626},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.15119081735610962},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.14343097805976868},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.141677588224411},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08865445852279663}],"concepts":[{"id":"https://openalex.org/C2780353609","wikidata":"https://www.wikidata.org/wiki/Q1569064","display_name":"Artificial pancreas","level":4,"score":0.7597454190254211},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.7233768105506897},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.660658061504364},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6585626602172852},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6440783739089966},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5025942325592041},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.4305555522441864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41815340518951416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38349631428718567},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3826351761817932},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32497847080230713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21126344799995422},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1892406940460205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17768627405166626},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.15119081735610962},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.14343097805976868},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.141677588224411},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08865445852279663},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cdc.2013.6759870","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2013.6759870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"52nd IEEE Conference on Decision and Control","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W178056938","https://openalex.org/W1606082921","https://openalex.org/W1969500525","https://openalex.org/W1985246220","https://openalex.org/W2003735994","https://openalex.org/W2005300371","https://openalex.org/W2020139135","https://openalex.org/W2061872918","https://openalex.org/W2068115312","https://openalex.org/W2083402819","https://openalex.org/W2096703445","https://openalex.org/W2099020006","https://openalex.org/W2113433055","https://openalex.org/W2114211585","https://openalex.org/W2121010183","https://openalex.org/W2134017961","https://openalex.org/W2138487775","https://openalex.org/W2144785271","https://openalex.org/W2160052863","https://openalex.org/W2167160009","https://openalex.org/W2409306358","https://openalex.org/W2940460024","https://openalex.org/W3110471395","https://openalex.org/W4241991023","https://openalex.org/W6714400196"],"related_works":["https://openalex.org/W2227061539","https://openalex.org/W2992709639","https://openalex.org/W2144785271","https://openalex.org/W2594910449","https://openalex.org/W2010116591","https://openalex.org/W1758514097","https://openalex.org/W1997101420","https://openalex.org/W2090099591","https://openalex.org/W2410816841","https://openalex.org/W2477866235"],"abstract_inverted_index":{"This":[0],"paper":[1],"investigates":[2],"the":[3,29,56,59,66,77,83,97,117,128,143,187],"expected":[4],"clinical":[5,60,172],"performance":[6,61,135],"and":[7,15,31,45,62,87,127,181],"robustness":[8,63,93],"envelope":[9,64],"(e.g.,":[10],"postprandial":[11],"blood":[12,17,166],"glucose":[13,18,102,167],"peak":[14],"low":[16,165],"condition":[19],"risk)":[20],"of":[21,35,42,58,85,108,189],"an":[22,48],"artificial":[23],"pancreas":[24],"(AP)":[25],"with":[26,119],"respect":[27],"to":[28,185],"pharmacokinetic":[30,124],"pharmacodynamic":[32],"(PK/PD)":[33],"characteristics":[34],"different":[36],"insulin":[37,43,49,109,151,177],"delivery":[38,152,178],"options":[39,179],"(i.e.,":[40,164],"combinations":[41],"formulations":[44],"routes).":[46],"Specifically,":[47],"PK/PD":[50,110,144,191],"based":[51,75],"design":[52],"method":[53,79],"that":[54,96,116,147],"enables":[55],"investigation":[57],"using":[65,174],"internal":[67],"model":[68],"control":[69],"methodology":[70],"is":[71],"introduced.":[72],"The":[73,92,112],"controller":[74,98,118,129],"on":[76,82],"proposed":[78],"was":[80],"evaluated":[81],"Universities":[84],"Virginia":[86],"Padova":[88],"FDA-accepted":[89],"metabolic":[90],"simulator.":[91],"analyses":[94],"suggest":[95,115],"can":[99,132],"achieve":[100,133],"safe":[101],"regulation":[103],"over":[104,142],"a":[105,148,161],"wide":[106],"range":[107],"characteristics.":[111,192],"simulation":[113],"results":[114,173],"only":[120],"two":[121,170],"parameters":[122],"(the":[123],"time":[125,130],"constant":[126],"constant)":[131],"satisfactory":[134],"(meal":[136],"disturbance":[137,157],"rejection":[138,158],"within":[139],"3.5":[140],"h)":[141],"range,":[145],"demonstrating":[146],"faster":[149],"acting":[150,176],"option":[153],"achieves":[154],"superior":[155],"meal":[156],"without":[159],"inducing":[160],"dangerous":[162],"overshoot":[163],"condition).":[168],"Additionally,":[169],"sample":[171],"fast":[175],"(inhaled":[180],"intraperitoneal)":[182],"are":[183],"given":[184],"illustrate":[186],"benefit":[188],"improving":[190]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}