{"id":"https://openalex.org/W2042497079","doi":"https://doi.org/10.1109/cdc.2013.6759869","title":"A predictive model for the anticoagulant bivalirudin administered to cardiac surgical patients","display_name":"A predictive model for the anticoagulant bivalirudin administered to cardiac surgical patients","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2042497079","doi":"https://doi.org/10.1109/cdc.2013.6759869","mag":"2042497079","pmid":"https://pubmed.ncbi.nlm.nih.gov/24781880"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2013.6759869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2013.6759869","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"52nd IEEE Conference on Decision and Control","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101722880","display_name":"Qi Zhao","orcid":"https://orcid.org/0000-0002-5267-8046"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Zhao","raw_affiliation_strings":["Division of Systems Engineering, Boston University, Boston, MA 02215, zhaoqi@bu.edu","Div. of Syst. Eng., Boston Univ., Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Engineering, Boston University, Boston, MA 02215, zhaoqi@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Div. of Syst. Eng., Boston Univ., Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058952071","display_name":"Thomas Edrich","orcid":"https://orcid.org/0000-0002-6228-9116"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Edrich","raw_affiliation_strings":["Department of Anesthesia, Perioperative and Pain medicine, Brigham and Women's Hospital, Boston, MA 02215, tedrich@partners.org","Dept. of Anesthesia, Perioperative & Pain Med., Brigham & Women's Hosp., Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Perioperative and Pain medicine, Brigham and Women's Hospital, Boston, MA 02215, tedrich@partners.org","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dept. of Anesthesia, Perioperative & Pain Med., Brigham & Women's Hosp., Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075696701","display_name":"Ioannis Ch. Paschalidis","orcid":"https://orcid.org/0000-0002-3343-2913"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis C. Paschalidis","raw_affiliation_strings":["Dept. of Electrical & Computer Eng., Division of Systems Eng., and Center for Information & Systems Eng., Boston University, 8 St. Mary's St., Boston, MA 02215, yannisp@bu.edu , url: http://ionia.bu.edu/","Dept. of Electr. & Comput. Eng., Boston Univ., Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Eng., Division of Systems Eng., and Center for Information & Systems Eng., Boston University, 8 St. Mary's St., Boston, MA 02215, yannisp@bu.edu , url: http://ionia.bu.edu/","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Boston Univ., Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4998,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.78268064,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"121","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bivalirudin","display_name":"Bivalirudin","score":0.8980756998062134},{"id":"https://openalex.org/keywords/partial-thromboplastin-time","display_name":"Partial thromboplastin time","score":0.5920190215110779},{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.5911941528320312},{"id":"https://openalex.org/keywords/kalman-filter","display_name":"Kalman filter","score":0.5384025573730469},{"id":"https://openalex.org/keywords/heparin","display_name":"Heparin","score":0.5057559013366699},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.496404230594635},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.44498351216316223},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.42529425024986267},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3932594060897827},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3400493264198303},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.31550484895706177},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26001203060150146},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23527050018310547},{"id":"https://openalex.org/keywords/coagulation","display_name":"Coagulation","score":0.09337714314460754}],"concepts":[{"id":"https://openalex.org/C2777565915","wikidata":"https://www.wikidata.org/wiki/Q4919218","display_name":"Bivalirudin","level":4,"score":0.8980756998062134},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.5920190215110779},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5911941528320312},{"id":"https://openalex.org/C157286648","wikidata":"https://www.wikidata.org/wiki/Q846780","display_name":"Kalman filter","level":2,"score":0.5384025573730469},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5057559013366699},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.496404230594635},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44498351216316223},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.42529425024986267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3932594060897827},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3400493264198303},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.31550484895706177},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26001203060150146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23527050018310547},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.09337714314460754},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cdc.2013.6759869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2013.6759869","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"52nd IEEE Conference on Decision and Control","raw_type":"proceedings-article"},{"id":"pmid:24781880","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24781880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control","raw_type":null},{"id":"pmh:oai:europepmc.org:2977614","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4000698","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G748954555","display_name":null,"funder_award_id":"R01 GM093147","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2022496424","https://openalex.org/W2102296549","https://openalex.org/W2117011443","https://openalex.org/W2121251309","https://openalex.org/W2130652855","https://openalex.org/W2491009754","https://openalex.org/W3022404379","https://openalex.org/W4242209908","https://openalex.org/W6681158678"],"related_works":["https://openalex.org/W2623252819","https://openalex.org/W2914781528","https://openalex.org/W2512939430","https://openalex.org/W2111460972","https://openalex.org/W42324470","https://openalex.org/W2550836649","https://openalex.org/W4380795623","https://openalex.org/W1826812333","https://openalex.org/W2324383132","https://openalex.org/W2433599465"],"abstract_inverted_index":{"Bivalirudin":[0],"is":[1,9,16,26,122],"used":[2,19],"in":[3,127],"patients":[4],"with":[5,23],"heparin-induced":[6],"thrombocytopenia":[7],"and":[8],"a":[10,17,30,58,64],"direct":[11],"thrombin":[12],"inhibitor.":[13],"Since":[14],"it":[15,101],"rarely":[18],"drug,":[20],"clinical":[21],"experience":[22],"its":[24,47],"dosing":[25],"sparse.":[27],"We":[28,51],"develop":[29],"model":[31,54,86,94,114],"that":[32,62,83],"predicts":[33],"the":[34,40,79,97,104,109],"effect":[35],"of":[36,67],"bivalirudin,":[37],"measured":[38],"by":[39,56],"Partial":[41],"Thromboplastin":[42],"Time":[43],"(PTT),":[44],"based":[45,77],"on":[46,78,118],"past":[48],"fusion":[49],"rates.":[50],"learn":[52],"population-wide":[53],"parameters":[55,87],"solving":[57],"nonlinear":[59],"optimization":[60],"problem":[61],"uses":[63],"training":[65],"set":[66],"patient":[68,120],"data.":[69],"More":[70],"interestingly,":[71],"we":[72,116],"devise":[73],"an":[74],"adaptive":[75,93],"algorithm":[76],"extended":[80],"Kalman":[81],"filter":[82],"can":[84],"adapt":[85],"to":[88,124],"individual":[89],"patients.":[90],"The":[91,113],"latter":[92],"emerges":[95],"as":[96,100],"most":[98],"promising":[99],"reduces":[102],"both":[103],"mean":[105],"error":[106,111],"and,":[107],"drastically,":[108],"per-patient":[110],"variance.":[112],"accuracy":[115],"demonstrate":[117],"actual":[119],"measurements":[121],"sufficient":[123],"be":[125],"useful":[126],"guiding":[128],"optimal":[129],"therapy.":[130]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
